CLINICAL CHARACTERISTIC OF COVID-19 IN ELDERLY AND MIDDLE-AGE ADULT IN DR MOHAMMAD SOEWANDHI GENERAL HOSPITAL

Yudita Wulandari, Vincentius Diamantino Supit, Henry Asaleo, Regita Marentek, Jansen Irawan, Rio Tritanto, Richard Hartanto, Steven Hermantoputra Halim

Abstract


Introduction: The different characteristics of the elderly and young people may provide different characteristics of COVID-19. This research aim is to provide information on the characteristics of COVID-19 patients, especially elderly patients. Aim: To analyzed comparisson of clinical characteristic COVID-19 in elderly and young age patients. Method: This study is a retrospective observational study with a cross-sectional approach in COVID-19 patients hospitalized at Soewandi General Hospital from May 1st 2020 until November 31th 2020. This study compared the characteristics of COVID-19 patients at elderly and young ages. Result: There were 368 COVID-19 patients with 95 elderly patients (25.81%) and 273 young patients (74.19%). The most frequent symptoms experienced by elderly patients in sequence are cough, gastrointestinal disturbances, fever, and fatigue. It was found that the proportion of COVID-19 patients with comorbid diabetes mellitus (DM) and hypertension (HT) was higher in elderly patients than in younger patients (p <0.05). There were statistically significant
differences in the values of hemoglobin (Hb), lymphocytes, hematocrit, mean platelet volume (MPV), neutrophil-lymphocyte ratio (NLR), SGPT, blood urea nitrogen (BUN), serum creatinine (Sc), and D-Dimer between the elderly and young age groups (p <0.05). Conclusion: COVID-19 has different clinical and laboratory characteristics between the elderly and young population. In the elderly infected with COVID-19 population, we need more comprehensive clinical and laboratory evaluation to prevent COVID-19 morbidity and mortality. Keryword: COVID-19, elderly patients, hematologic parameter

Save to Mendeley


Keywords


COVID-19, elderly patients, hematologic parameter

Full Text:

PDF

References


WHO. Coronavirus disease 2019 (COVID-19) situation report 23. Published 2020. www.who.int/docs/default-source/coronaviruse/ situation-reports/20200212-sitrep-23-ncov.pdf.

Satuan Tugas Penanganan COVID-19. Peta Sebaran COVID-19. Published 2020. Accessed February 15, 2021. https://covid19.go.id/peta-sebaran-covid193. Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497-506. doi:10.1016/S0140-6736(20)30183-5

Guo T, Shen Q, Guo W, et al. Clinical Characteristics of Elderly Patients with COVID-19 in Hunan Province , China : A Multicenter , Retrospective Study. Gerontology. 2020;410011(139):467-475. doi:10.1159/000508734

Liu K, Chen Y, Lin R, Han K. Clinical features of COVID-19 in elderly patients : A comparison with young and middle-aged patients. J Infect. 2020;80(6):e14-e18. doi:10.1016/j.jinf.2020.03.005

Azwar MK, Setiati S, Rizka A, Fitriana I, Saldi SRF, Safitri ED. Clinical Profile of Elderly Patients with COVID-19 Hospitalized in Indonesia ’ s National General Hospital. Indones J Intern Med. 2020;52(3):199-205.

Wang T, Du Z, Zhu F, et al. Comorbidities and multi-organ injuries in the treatment of COVID-19. Lancet. 2020;395(10228):e52. doi:10.1016/S0140-6736(20)30558-4

Erlina Burhan, Agus Dwi Susanto, Sally Aman Nasution, Eka Ginanjar, Ceva Wicaksono Pitoyo, Adityo Susilo et al. PEDOMAN TATALAKSANA COVID-19 Edisi 3 TIM EDITOR Perhimpunan Dokter Paru Indonesia (PDPI) Perhimpunan Dokter Spesialis Kardiovaskular Indonesia (PERKI) Perhimpunan Dokter Spesialis Penyakit Dalam Indonesia (PAPDI) Perhimpunan Dokter Anestesiologi Dan Terap.; 2020.

Lakbar I, Luque-Paz D, Mege JL, Einav S, Leone M. COVID-19 gender susceptibility and outcomes: A systematic review. PLoS One. 2020;15(11 November):1-15. doi:10.1371/journal.pone.0241827

Liu K, Chen Y, Lin R, Han K. Clinical features of COVID-19 in elderly patients: A comparison with young and middle-aged patients. J Infect. 2020;80(6):e14-e18. doi:10.1016/j.jinf.2020.03.005

Shi Q, Zhang X, Jiang F, et al. Clinical Characteristics and Risk Factors for Mortality of COVID-19 Patients with Diabetes in Wuhan, China: A Two-Center, Retrospective Study. Diabetes Care. 2020;43(7):1382-1391. doi:10.2337/dc20-0598

Muniyappa R, Gubbi S. COVID-19 pandemic, coronaviruses, and diabetes mellitus. Am J Physiol - Endocrinol Metab. 2020;318(5):E736-E741. doi:10.1152/ajpendo.00124.2020

Fernandez C, Rysä J, Almgren P, et al. Plasma levels of the proprotein convertase furin and incidence of diabetes and mortality. J Intern Med. 2018;284(4):377-387. doi:10.1111/joim.12783

Zhang P, Wang M, Wang Y, Wang Y, Li T, Zeng J. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID- 19 . The COVID-19 resource centre is hosted on Elsevier Connect , the company ’ s public news and information . 2020;(January).

Bornstein SR, Rubino F, Khunti K, et al. Practical recommendations for the management of diabetes in patients with COVID-19. 2020;(January). doi:https://doi.org/10.1016/ S2213-8587(20)30152-2

Chobanian A V., Bakris GL, Black HR, et al. The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: The JNC 7 Report. J Am Med Assoc. 2003;289(19):2560-2572. doi:10.1001/jama.289.19.2560

Alfie J, Cuffaro PE. Hypertension in the elderly. Encycl Biomed Gerontol. 2019;4(5):258-270. doi:10.1016/B978-0-12-801238-3.62166-9

Guan W, Ni Z, Hu Y, et al. Clinical Characteristics of Coronavirus Disease 2019 in China. N Engl J Med. 2020;382(18):1708-1720. doi:10.1056/NEJMoa2002032

Grasselli G, Zangrillo A, Zanella A, et al. Baseline Characteristics and Outcomes of 1591 Patients Infected with SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy. JAMA - J Am Med Assoc. 2020;323(16):1574-1581. doi:10.1001/jama.2020.5394

Khan M, Khan H, Khan S, Nawaz M. Epidemiological and clinical characteristics of coronavirus disease (COVID-19) cases at a screening clinic during the early outbreak period: a single-centre study. J Med Microbiol. 2020;69(8):1114-1123. doi:10.1099/jmm.0.001231

Guo T, Shen Q, Guo W, et al. Clinical Characteristics of Elderly Patients with COVID-19 in Hunan Province, China: A Multicenter, Retrospective Study. Gerontology. 2020;66(5):467-475. doi:10.1159/000508734

Fabio P, Graziamaria C. COVID‑19 and the elderly insights into pathogenesis.pdf. 2020. doi:https://doi.org/10.1007/s40520-020-01631-y

Bergamaschi G, de Andreis FB, Aronico N, et al. Anemia in patients with Covid-19: pathogenesis and clinical significance. Clin Exp Med. January 2021. doi:10.1007/s10238-020-00679-4

Wei C, Liu Y, Liu Y, et al. Clinical characteristics and manifestations in older patients with COVID-19. BMC Geriatr. 2020;20(1):1-9. doi:10.1186/s12877-020-01811-5

Zhao K, Li R, Wu X, et al. Clinical features in 52 patient. 2020.

Yun H, Sun Z, Wu J, Tang A, Hu M, Xiang Z. Laboratory data analysis of novel coronavirus (COVID-19) screening in 2510 patients. Clin Chim Acta. 2020;507(January):94-97. doi:10.1016/j.cca.2020.04.018

Zhong Q, Peng J. Mean platelet volume/platelet count ratio predicts severe pneumonia of COVID-19. J Clin Lab Anal. 2020;(September):1-9. doi:10.1002/jcla.23607

Perrotta F, Corbi G, Mazzeo G, et al. COVID-19 and the elderly: insights into pathogenesis and clinical decision-making. Aging Clin Exp Res. 2020;32(8):1599-1608. doi:10.1007/s40520-020-01631-y

Fox SE, Akmatbekov A, Harbert JL, Li G, Quincy Brown J, Vander Heide RS. Pulmonary and cardiac pathology in African American patients with COVID-19: an autopsy series from New Orleans. Lancet Respir Med. 2020;8(7):681-686. doi:10.1016/S2213-2600(20)30243-5

Pinti M, Appay V, Campisi J, et al. Aging of the immune system: Focus on inflammation and vaccination. Eur J Immunol. 2016;46(10):2286-2301. doi:10.1002/eji.201546178

Liu J, Liu Y, Xiang P, et al. Neutrophil-to-lymphocyte ratio predicts critical illness patients with 2019 coronavirus disease in the early stage. J Transl Med. 2020;18(1):1-12. doi:10.1186/s12967-020-02374-0

Lian J, Jin C, Hao S, et al. High neutrophil-to-lymphocyte ratio associated with progression to critical illness in older patients with COVID-19: A multicenter retrospective study. Aging (Albany NY). 2020;12(14):13849-13859. doi:10.18632/aging.103582

Huang I, Pranata R. Lymphopenia in severe coronavirus disease-2019 (COVID-19): Systematic review and meta-analysis. J Intensive Care. 2020;8(1):1-10. doi:10.1186/s40560-020-00453-4

Wang L, He W, Yu X, Hu D, Bao M. Coronavirus disease 2019 in elderly patients : Characteristics and prognostic factors based on 4-week follow-up. 2020;80:639-645. doi:10.1016/j.jinf.2020.03.019

Ali N. Relationship Between COVID-19 Infection and Liver Injury : A Review of Recent Data. 2020;7(July):1-6. doi:10.3389/fmed.2020.00458

Gao, S., Jiang, F., Jin, W., Shi, Y., Yang, L., Xia, Y., Jia, L., Wang, B., Lin, H., Cai, Y., Xia, Z., & Peng J. Risk factors influencing the prognosis of elderly patients infected with COVID-19: a clinical retrospective study in Wuhan, China. Aging (Albany NY). 2020;12(13):12504–12516. doi:10.18632/aging.103631

Pan XW, Xu D, Zhang H, Zhou W, Wang LH CX. Identification of a potential mechanism of acute kidney injury during the COVID-19 outbreak: a study based on single-cell transcriptome analysis. Intensive Care Med. 2020;46::1114–16. doi:10.1007/s00134-020-06026-1

Yuan X, Xu X, Tong X, Wang Y, Wang H, Wang L. Coagulopathy in elderly patients with coronavirus disease 2019. 2020;(July):260-265. doi:10.1002/agm2.12133

Ozen M, Yilmaz A, Cakmak V, et al. D-Dimer as a potential biomarker for disease severity in COVID-19. 2020;40:55-59. doi:10.1016/j.ajem.2020.12.023




DOI: https://doi.org/10.33508/jwm.v7i2.3069