2024-03-29T12:49:39Z
http://journal.wima.ac.id/index.php/index/oai
oai:ojs.jurnal.wima.ac.id:article/3219
2021-11-26T14:50:54Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/3219
2021-11-26T14:50:54Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 8, No 2 (2021): Oktober; 85-90
Pharmacological effects and pharmaceutical dosage forms development of aloe vera
Almaamari, Jamal Nasser Saleh; Airlangga University
2021-11-26 15:50:49
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/3219
aloe vera; pharmaceutical dosage forms; pharmacological effects; product development.
Airlangga University
en
The Aloe Vera plant is one of the oldest plants used for thousands of years. Aloe Vera has been used as a herb that cures multiple diseases throughout history. The series of studies conducted in the past two decades shed light on the chemical properties and natural compounds that this plant contains, such as anthraquinone, amino acids, acemannan, aloesin, and glucomannan, which have diverse therapeutic effects. This review aimed at reviewing the pharmacological effects of aloe vera plant and its different pharmaceutical dosage forms. The data was collected from international published literature in PMID and Google Scholar. It is to conclude that the Aloe Vera has therapeutics effects such as anti-inflammatory, wound healing, anti-oxidation, anticancer, anti-tumor, antiulcer, antiviral and antibacterial, and anti-cholesterol. In addition, some pharmaceutical formulations of aloe vera such as suppositories, creams, gels, and tablets can be developed.
oai:ojs.jurnal.wima.ac.id:article/2056
2019-05-23T12:42:41Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/2056
2019-05-23T12:42:41Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 5, No 1 (2018); 53-58
Uji Antipiretik Patch Ekstrak Etanol Bawang Merah (Allium ascalonicum L.) dengan Matriks Chitosan dan Enhancer Tween-80
Willyanto, Jennifer Rachel; Fakultas Farmasi Universitas Katolik Widya Mandala Surabaya
Hamid, Iwan Sahrial; Fakultas Kedokteran Hewan, Universitas Airlangga, Surabaya
Widodo, Teguh; Fakultas Farmasi, Universitas Katolik Widya Mandala Surabaya
2018-05-23 00:00:00
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/2056
id
Onion is a traditional medicine that has a lot of pharmacological potential. Flavanoid compounds found in onions have an antipyretic effect that acts as an inhibitor of cyclooxygenase (COX) enzymes that play a role in the
formation of prostaglandins. In this study red onion is formulated into a patch because of its practical use and can avoid the first metabolic pathway. This study aims to analyze the effect of onion ethanol extract patch (Allium
ascalonicum L.) on the decrease of body temperature and the number of monocytes in white rats induced by DPT vaccine. This study used 4 treatment groups: positive controls administered paracetamol syrup, negative controls given placebo patch, treatment group 1 treated with red onion ethanol extract without enhancers and treatment group 2 treated with an red onion ethanol extract with enhancers. Rats adapted for 7 days before temperature being measured and the blood being collected from the rat tail in order to calculate the number of monocytes. The animal temperature was measured after injected with vaccine DPT at 15, 30, 45, 60, 75, 90, 105, 120, 150, 180 minutes meanwhile number of monocyte were calculated every 15 minutes for 120 minutes. The results showed
that there was no significant difference in monocyte count of treatment group with positive control but there were significant differences in temperature. The use of onion ethanol extract patch may decrease the temperature and number of monocytes in white mice induced by DPT vaccine.
oai:ojs.jurnal.wima.ac.id:article/2141
2019-09-13T14:01:12Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/2141
2019-09-13T14:01:12Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 5, No 2 (2018); 87-93
Uji Antipiretik Patch Ekstrak Etanol Bawang Merah (Allium ascalonicum L.) dengan Matriks Kitosan dan Enhancer SPAN-80 terhadap Temperatur dan Jumlah Makrofag pada Tikus Putih
Kariyaningtias, Vivi; Fakultas Farmasi, Universitas Katolik Widya Mandala, Surabaya
Hamid, Iwan Sahrial; Fakultas Kedokteran Hewan, Universitas Airlangga, Surabaya
Widodo, Teguh; Fakultas Farmasi, Universitas Katolik Widya Mandala, Surabaya
2019-09-13 16:01:02
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/2141
id
Traditional medicine can be used to treat various diseases, one of which is onion (Allium ascalonicum L.) as an antipyretic agent. In this study, the antipyretic potency of ethanol extract of onion (Allium ascalonicum L.) was
tested using chitosan and Span-80 as enhancer matrix with temperature and number of intraperitoneal macrophages in white rats as parameters. This study used 20 male white rats Wistar that were induced with DPTHb
vaccine intraperitoneally and then divided into four groups namely positive control group (paracetamol), negative control (placebo without extract and without enhancer), formulation 1 (with extract and without enhancer), and formulation 2 (with extracts and enhancers). The results were analyzed using One Way Anova and if the results were significant, then the test continued with Duncan 5%. Correlation calculations were used to
determine the relationship between temperature reduction and total intraperitoneal macrophages. The results showed that the temperature reduction did not provide a significant difference between the positive control (paracetamol) and formulation 2 (with extracts and enhancers), whereas in the negative control (without extract and without enhancer) there was no significant difference with formulation 1 (with extract and without enhancers). The total results of intraperitoneal macrophages were significantly different in all groups with a significant> 0.05.
oai:ojs.jurnal.wima.ac.id:article/4059
2023-04-12T02:22:58Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/4059
2023-04-12T02:22:58Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 9, No 1 (2022): Februari; 24-29
Studi Perbandingan Sifat Struktur dan Dinamika Bentuk Apo dan Holo dari FKBP12 dan Mip dengan Menggunakan Simulasi Dinamika Molekul
Widjajakusuma, Elisabeth Catherine; Faculty of Pharmacy, Widya Mandala Catholic University Surabaya
Frederica, Monica; Faculty of Pharmacy, Widya Mandala Catholic University Surabaya
Kaweono, Kornelius; Faculty of Pharmacy, Widya Mandala Catholic University Surabaya
Shea, Arkenjela; Faculty of Pharmacy, Widya Mandala Catholic University Surabaya
Jawa, Gracia De Sales Lodhu; Faculty of Pharmacy, Widya Mandala Catholic University Surabaya
Kelan, Yohanes Aliandra; Faculty of Pharmacy, Widya Mandala Catholic University Surabaya
Indah, Ajeng; Faculty of Pharmacy, Widya Mandala Catholic University Surabaya
An’nisavia, Firli; Faculty of Pharmacy, Widya Mandala Catholic University Surabaya
Simatupang, Margaretha Yuliani Br; Faculty of Pharmacy, Widya Mandala Catholic University Surabaya
Fildzahdina, Fildzahdina; Faculty of Pharmacy, Widya Mandala Catholic University Surabaya
Setiyoningsih, Dwi Vita; Faculty of Pharmacy, Widya Mandala Catholic University Surabaya
2022-03-30 00:00:00
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/4059
FKBP12; Mip (macrophage infectivity potentiator); Legionella pneumophila; simulasi dinamika molekul; potensial flooding
id
Interaksi protein danligan pada sisi pengikatan merupakan topik penting dalam desain obat dan proses prediksi fungsi protein. FKBP12 dan Mip(macrophage infectivity potentiator)termasuk dalam keluarga protein FKBP dengan sisi pengikatan yang kemiripannya sangat tinggi. Oleh karena itu untuk mendapatkan ligan yang selektif tidaklah mudah. Tujuan penelitian ini untuk membandingkan sifat struktur dan dinamis dari FKBP12 dan Mip dalam bentuk holo (membentuk kompleks dengan suatu ligan) dan bentuk apo (tidak terikat dengan ligan) dengan menggunakan simulasi dinamika molekul selama 40 ns dengan penambahan energi potensial selama 10 ns. Penggantian ligan rapamycin dengan ligan yang lebih kecil, yaitu turunan asam pipecolat, menyebabkan perubahan strukturpada FKBP12 dibandingkan Mip terutama pada asam amino Q81/E54, V82/F55, I83/I56, W86/W59, Y109/Y82, P117/H87, dan I118/I90.Hal ini memberikan informasi untuk pengembangan ligan yang selektif.
oai:ojs.jurnal.wima.ac.id:article/2172
2019-10-14T10:20:12Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/2172
2019-10-14T10:20:12Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 4, No 1 (2017); 7-10
Perbandingan Sintesis antara Senyawa 4’-Nitrokhalkon dan 2,4- Dimetoksi-4’-Nitrokhalkon dengan Bantuan Iradiasi Gelombang Mikro
Shien, Ong Cong; Fakultas Farmasi, Universitas Katolik Widya Mandala, Surabaya
Soewandi, Ami; Fakultas Farmasi, Universitas Katolik Widya Mandala, Surabaya
Caroline, Catherin; Fakultas Farmasi, Universitas Katolik Widya Mandala, Surabaya
2019-10-14 12:20:06
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/2172
id
Chalcone (1,3-diphenylprop-2-en-1-one) is a precursor compound of flavonoids that have two aromatic rings connected by three α, β-unsaturated carbons. Chalcone can be synthesized by the base-catalysed crossed aldol condensation (Claisen-Schmidt) using the reaction between aromatic aldehyde with aryl ketone. In this research, synthesize of 4-nitrochalcone and 2,4-dimethoxy-4’-nitrochalcone compounds with microwave irradiation assistance had been done. 4-nitrochalcone was synthesized from acetophenone and 4’-nitrobenzaldehyde, while
2,4-dimethoxy-4’-nitrochalcone was synthesized from 2,4-dimethoxyacetophenone and 4’-nitrobenzaldehyde. The purity of the synthesis compounds were shown from the data of melting point and thin layer chromatography. Identification of structure was shown from infrared spectral data and proton nuclear magnetic resonance. From the obtained results, 4-nitrochalcone and 2,4-dimethoxy-4’-nitrochalcone compounds can be synthesized by microwave irradiation assistance. The yield of 4’-nitrochalcone was 58.19%, while 2,4-dimethoxy-4’-nitrochalcone was 19.07%. The effect of methoxy groups (-OCH3) on acetophenoe ease the reaction of the formation of chalcone compounds in terms of yield of the synthesis product.
oai:ojs.jurnal.wima.ac.id:article/3354
2023-04-12T02:22:57Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/3354
2023-04-12T02:22:57Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 9, No 1 (2022): Februari; 7-11
Tingkat Pengetahuan dan Sikap Mahasiswa terhadap Pemilihan Suplemen Kesehatan dalam Menghadapi COVID-19
Puspasari, Heny; Akademi Farmasi Yarsi Pontianak
Puspita, Weni; Akademi Farmasi Yarsi Pontianak
2022-03-30 00:00:00
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/3354
Knowledge Level; Attitude; Health Supplements; Covid 19
Kementerian Pendidikan dan Kebudayaan Indonesia, Ristekdikti
id
Covid-19 di Indonesia dinyatakan sebagai jenis penyakit yang menimbulkan kedaruratan kesehatan masyarakat serta bencana non alam, yang tidak hanya menyebabkan kematian tapi juga menimbulkan kerugian ekonomi yang cukup besar. Menghadapi masalah ini, maka diperlukan upaya pengendalian dan pencegahan Covid-19 ini Salah satu upaya pencegahan yang dapat dilakukan adalah dengan meningkatkan ketahanan masyarakat melalui kesehatan tubuh perorangan. Penelitian ini bertujuan untuk menganalisis pengetahuan dan sikappenerapan penggunaan suplemen kesehatan pada mahasiswa-mahasiswi di Akademi Farmasi Yarsi Pontianak di masa pandemi ini. Metode penelitian yang digunakan adalah metode survei deskriptif dengan menggunakan pendekatan analisis ku antitatif pada mahasiswa-mahasiswi aktif semua tingkat/semester di Akademi Farmasi Yarsi Pontianak. Pengambilan data secaraprospektif dengan teknik sampling Stratified Random Sampling.Penelitian ini dilakukan dengan pemberian kuesioner melalui google form. Hasil penelitian menunjukkan bahwa dari 100 orang mahasiswa, didapatkan tingkat pengetahuan termasuk kategori cukup sebanyak 8 orang (8,0%)dan mahasiswa dengan tingkat pengetahuan baik sebanyak 92 orang (92,0%), serta sikap tidak baik sebanyak 16 orang (16,0%) dan kategori sikap baik sebanyak 84 orang (84,0%). Dengan demikian dapat disimpulkan bahwa tingkat pengetahuan mahasiswa sudah baik dan memiliki sikap yang baik terhadap pemilihan suplemen kesehatan dalam menghadapi Covid-19 pada era pandemi
oai:ojs.jurnal.wima.ac.id:article/2177
2019-10-14T10:20:12Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/2177
2019-10-14T10:20:12Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 4, No 1 (2017); 36-43
Studi Penggunaan Omeprazole pada Pasien Sirosis Hati dengan Hemetamesis Melena Rawat Inap di RSUD Kabupaten Sidoarjo
Wiranata, I Made; Fakultas Farmasi, Universitas Katolik Widya Mandala Surabaya
Hasmono, Didik; Fakultas Farmasi, Universitas Airlangga, Surabaya
Surdijati, Siti; Fakultas Farmasi, Universitas Katolik Widya Mandala Surabaya
2019-10-14 12:20:06
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/2177
id
Liver cirrhosis is a process of liver cell damage which later becomes fibrosis tissue. Then, the occurrence of liver structural distortion and increased vascularization to the liver resulting in varicose veins or dilation of blood
vessels in the gastrointestinal and esophageal areas. Patients with esophageal varices, there is a risk of bleeding from esophageal rupture, the undergone hematemesis (vomiting of blood) and melena (blackish defecate). The therapies used to reduce gastrointestinal bleeding are gastric ulcers drugs such as H2Ras and PPI. The study aimed to determine the pattern of omeprazole use in liver cirrhosis patients with hematemesis melena. The method used was an observational retrospective study in medic record data patients. Sampling was done by consecutive sampling, the period of Juli 1, 2015 until Descember 31, 2015. The results obtained from the study were single use of omeprazole with a dose of 2x40mg/i.v used the most by 22 patients (73.3%). The use of omeprazole with a dose of
2x40mg/i.v combined with other gastric ulcer drugs was 7 patients (23.3%), omeprazole with ranitidin 6 patients, omeprazole with antacid for 1 patient. The use of omeprazole with a dose of 2x40mg was replaced with ranitidin
2x25mg/ml was 1 patient (3.3%). The use of omeprazole given in liver cirrhosis patients with hematemesis melena at the Inpatient Installation of Regional Hospital of Sidoarjo, related dose, route, frequency, interval, and
duration of giving was in appropriate with the guidelines contained in the National Formulary.
oai:ojs.jurnal.wima.ac.id:article/4079
2023-03-15T14:35:07Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/4079
2023-03-15T14:35:07Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 9, No 2 (2022): October; 81-86
Deteksi populasi Cd3+Cd4+Cd25+Foxp3+ T-regulator pada Limpa Mencit Galur Balb/c dan Swiss-webster yang Mudah dan Cepat dengan Metode Flow Cytometry
Tjahjono, Yudy; Universitas Katolik Widya Mandala Surabaya
Wijaya, Hendy; Universitas Katolik Widya Mandala Surabaya
Esar, Senny Yesery; Universitas Katolik Widya Mandala Surabaya
Caroline, Caroline; Universitas Katolik Widya Mandala Surabaya
Jafet, Nico; Universitas Katolik Widya Mandala Surabaya
Kusuma, I Made Andika Bara; Universitas Katolik Widya Mandala Surabaya
Chrisantia, Oryza; Universitas Katolik Widya Mandala Surabaya
Bhendy, Maria Theresia Primadewy; Universitas Katolik Widya Mandala Surabaya
Palpialy, Sindi Siska; Universitas Katolik Widya Mandala Surabaya
Soehadi, Shellin; Universitas Katolik Widya Mandala Surabaya
Wilianto, Yufita Ratnasari; Universitas Katolik Widya Mandala Surabaya
2022-10-30 00:00:00
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/4079
Sel Treg; Limpa; Flow cytometry; Isolasi
id
Sel T-regulator (Treg) memainkan peran kunci dalam mengendalikan autoimunitas, respon alergi, peradangan, dan respons terhadap infeksi. Sel T Cd4+ yang secara konstitutif mengekspresikan Cd25 dan protein forkhead 3 (Foxp3; yaitu, Cd3+Cd4+Cd25+Foxp3+) atau disebut juga sebagai Treg fungsional, telah terbukti memainkan peran utama dalam pemeliharaan toleransi dan homeostasis imun, sehingga deteksi Treg fungsional sangat penting dilakukan sebagai salah satu parameter imunomodulasi. Penelitian ini bertujuan untuk mendeteksi populasi sel Treg (Cd3+Cd4+Cd25+Foxp3+) pada organ limpa mencit galur Balb/c dan Swiss-webster dengan menggunakan metode yang mudah, cepat, serta terjangkau. Metode deteksi sel Treg dilakukan dengan cara isolasi organ limpa mencit Balb/c dan Swiss-webster kemudian dilakukan preparasi dan deteksi sel menggunakan instrumen flow cytometry. Hasil populasi sel Treg yang didapatkan berturut-turut pada mencit Balb/c dan Swiss-webster adalah 2,02 ± 0,36% dan 3,14 ± 1,64% dari total populasi yang dideteksi dengan hanya membutuhkan waktu 145 menit sejak pembedahan. Berdasarkan hasil tersebut dapat disimpulkan bahwa pengamatan populasi sel Treg pada splenosit mencit galur Balb/c dan Swiss-webster dengan flow cytometry dapat dilakukan dengan mudah dan praktis dengan pewarnaan kombinasi antibodi yang tertera pada manuskrip ini. Selain itu, metode pewarnaan yang tertera dapat digunakan sebagai salah satu acuan untuk mendeteksi imunomodulator pada berbagai model hewan coba yang menggunakan mencit galur Balb/c dan Swiss-webster, khususnya yang berhubungan dengan populasi sel Treg.
oai:ojs.jurnal.wima.ac.id:article/2182
2019-10-14T11:39:53Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/2182
2019-10-14T11:39:53Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 4, No 2 (2017); 71-75
Pola Penggunaan Ranitidine pada Pasien HIV & AIDS di UPIPI RSUD DR. Soetomo Surabaya
Nurohmawati, Weni; Fakultas Farmasi, Universitas Katolik Widya Mandala Surabaya
Triyono, Erwin Astha; Rumah Sakit Umum Daerah Dr. Soetomo Surabaya
Surdijati, Siti; Fakultas Farmasi, Universitas Katolik Widya Mandala Surabaya
Jaya, Halim Priyahau; Rumah Sakit Umum Daerah Dr. Soetomo Surabaya
2019-10-14 12:31:26
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/2182
id
HIV is a retrovirus that attacks CD4 lymphocyte cells. AIDS is a retrovirus disease caused by infection with retrovirus HIV-1 or HIV-2 which causes opportunistic diseases, secondary neoplasms and neurological abnormalities. In patients with HIV & AIDS often experience gastrointestinal disorders such as nausea and vomiting caused by side effects of the use of antiretroviral or due to other factors. Ranitidine is an H2 inhibitory receptor that will selectively and reversibly reduce excess gastric acid secretion. In this study ranitidine was used as a stress ulcer prophylaxis in hospitalized patients. This study aims to display ranitidine therapy data including type, dose, route of drug administration, prevalence, duration of use and qualitative analysis of interactions associated with medical record data at UPIPI RSUD Dr. Soetomo Surabaya. The research method used was observational prospectively on patient medical record with HIV & AIDS. Sampling was carried out by consecutive sampling period from November 1, 2016 to December 31, 2016. The results of this study
give information that ranitidine was most widely used for stress ulcer prophylaxis therapy in hospitalized patients in UPIPI RSUD Dr. Soetomo Surabaya in a dose of 50mg / 2ml with a frequency of 2x1 while for oral ranitidine with a dose of 150mg / tablet with a frequency of 2x1. The use of ranitidine on HIV & AIDS patients in UPIPI RSUD Dr Soetomo Surabaya, related to dosage, route, frequency, interval, and duration of administration is in accordance with the existing guidelines.
oai:ojs.jurnal.wima.ac.id:article/693
2015-06-19T09:14:35Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/693
2015-06-19T09:14:35Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 2, No 1 (2015)
Aktivitas Antihiperlipidemia Ekstrak Etanol Daun Annona squamosa L.
Rofida, Siti; Prodi Farmasi, Fakultas Ilmu Kesehatan Universitas Muhammadiyah Malang
Firdiansyah, Ahmad
Fitriyastuti, Endah
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/693
en
Cause of cardiovascular disease risk factors, one of which is a high cholesterol levels in serum. Mortality
caused by cardiovascular disease as 17.3 million people. Annona squamosa L. or commonly referred custard
apple is a plant from family Annonaceae and have been used for insecticide, antitumor, antidiabetic,
antioxidant, anti-inflammatory, and antihyperlipidemia. The leaves of Annona squamosa L. contains acetogenin,
diterpene, flavonoids, lignin, hydroxyl ketones, and benzoquinazolin. The aims of this study is to determine
the optimum dose to reduce levels of LDL on hyperlipidemic rats. In this study, hyperlipidemic rats
were divided into 5 groups, negative control group (normal feed), positive control group (normal feed and simvastatin
at a dose of 0.9 mg/KgBW), treatment group 1 (normal feed and ethanol extract leaves of Annona
squamosa L. at a dose of 0.25 mg/gBB, treatment groups 2 (normal feed and ethanol extract leaf of Annona
squamosa L. at a dose of 0.75 mg/gBB, treatment groups 3 (normal feed and ethanol extract leaf of Annona
squamosa L. at a dose of 1 mg/gBB). The results of identification by thin-layer chromatography on ethanol
extract leaf of Annona squamosa L indicates the presence of flavonoids. The results showed that the ethanol
extract leaves of Annona squamosa Linn. On hyperlipidemia rats, can lower LDL cholesterol levels at doses of
0.25 mg/gram BB.
oai:ojs.jurnal.wima.ac.id:article/4486
2023-08-06T16:20:07Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/4486
2023-08-06T16:20:07Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 10, No 1 (2023): February; 14-24
Isolasi dan Identifikasi Bakteri Penyebab Bau Kaki
http://journal.wima.ac.id/index.php/JFST/article/download/4486/12172
Vernanda, Renna Yulia; Universitas Katolik Widya Mandala Surabaya
Ariyanti, Agnes Dwi; Universitas Katolik Widya Mandala Surabaya
Oktaviana, Claudia; Universitas Katolik Widya Mandala Surabaya
Gunawan, Firman Sandi; Universitas Katolik Widya Mandala Surabaya
Prastica, Yohana Maria Vianney; Universitas Katolik Widya Mandala Surabaya
Mauryn, Flora Raliana; Universitas Katolik Widya Mandala Surabaya
Rati, Angelica Krisensiani; Universitas Katolik Widya Mandala Surabaya
Hasfayo, Fridolin Putri; Universitas Katolik Widya Mandala Surabaya
Ribeiro, Margareta Vita; Universitas Katolik Widya Mandala Surabaya
2023-03-27 00:00:00
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/4486
foot odour; bacteria; fungi; yeast; cotton swab
Universitas Katolik Widya Mandala Surabaya
en
Foot odour is caused by combination of sweat and bacteria. Smelly feet can lead to lack of confidence and discomfort. In this study, conducted on 21 probands to isolate the microbes with the following criteria: male, aged 18-25 years, wore shoes for 8 hours without taking them off, moist, and smelly feet. Isolating microbes from the feet using a cotton swab. The result of the study found 7 isolates. Several bacteria isolates, namely: Staphylococcus sp, Bacillus sp, Enterobacter sp. In addition, isolates from fungi Aspergillus sp, Penicillium sp, Syncephalastrum sp, and Candida krusei yeast were isolate
oai:ojs.jurnal.wima.ac.id:article/4195
2023-08-06T16:20:07Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/4195
2023-08-06T16:20:07Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 10, No 1 (2023): February; 51-56
Uji Angka Lempeng Total (ALT) Dan Angka Kapang Khamir (AKK) Pada Jamu Gendong Di Pasar Tradisional Wonokriyo Kecamatan Gombong Kabupaten Kebumen
Hasanah, Saniati; Universitas Muhammadiyah Gombong
Kiromah, Naelaz Zukhruf Wakhidatul; Universitas Muhammadiyah Gombong
Fitriyati, Laeli; Universitas Muhammadiyah Gombong
2023-04-27 00:00:00
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/4195
Jamu gendong, Angka Lempeng Total, Angka Kapang Khamir
Program Studi Farmasi Program Sarjana, Fakultas Ilmu Kesehatan, Universitas Muhammadiyah Gombong
en
Latar Belakang: Jamu gendong merupakan salah satu obat tradisional yang sangat diminati oleh masyarakat dikarenakan manfaatnya yang dapat menjaga kesehatan serta mengobati penyakit. Jamu gendong tidak memerlukan izin edar, tetapi kualitas jamu harus tetap diperhatikan sehingga sediaan jamu aman dikonsumsi. Tujuan: Mengetahui ada tidaknya cemaran mikroba berupa bakteri dan kapang khamir pada sediaan jamu gendong beras kencur, kunyit asam, temulawak dan pahitan yang dijual di pasar tradisional Wonokriyo, Kecamatan Gombong, Kabupaten Kebumen. Metode: Sampel jamu diambil dari empat penjual yaitu penjual A, B, C dan D. Tahapan penelitian meliputi pengambilan sampel, homogenisasi sampel, uji angka lempeng total (ALT) dan uji angka kapang khamir (AKK). Data kemudian dianalisis menggunakan uji statistic One Way ANOVA. Hasil: Jamu gendong beras kencur, kunyit asam, temulawak dan pahitan yang dijual oleh penjual A, B, C dan D diperoleh nilai ALT yang memenuhi persyaratan yaitu tidak lebih dari >105 koloni/ml. Sedangkan jamu beras kencur yang dijual oleh penjual D diperoleh nilai ALT >105 koloni/ml sehingga tidak memenuhi persyaratan. Jamu gendong beras kencur, kunyit asam, temulawak dan pahitan diperoleh nilai AKK tidak lebih dari 103 koloni/ml sehingga memenuhi persyaratan. Tidak ada perbedaan yang signifikan (P>0,05) pada nilai ALT dan AKK dari semua jenis sampel jamu gendong yang berasal dari keempat penjual. Kesimpulan: Semua jamu memenuhi persyaratan mutu dilihat dari nilai AKK dan ALT, namun 1 sampel jamu beras kencur yang tidak memenuhi syarat ALT.
oai:ojs.jurnal.wima.ac.id:article/2224
2019-11-04T08:17:58Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/2224
2019-11-04T08:17:58Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 6, No 2 (2019); 56-65
Standarisasi Spesifik dan Non Spesifik dari Ekstrak Etanol Daun dandang Gendis (Clinacanthus nutans)
Wijaya, Sumi; Fakultas Farmasi Universitas Katolik Widya Mandala Surabaya
Setiawan, Henry Kurnia; Fakultas Farmasi Universitas Katolik Widya Mandala Surabaya
Purnama, Veronica Bella; Fakultas Farmasi Universitas Katolik Widya Mandala Surabaya
2019-10-31 22:14:29
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/2224
id
Standardization of natural materials is needed as an effort to improve the quality and safety of products that are expected to further increase trust in medicines derived from natural ingredients. Snake grass leaf has several
pharmacological activities including antioxidants, anticancer, anti-inflammatory, analgesic, enhancing the immune system, antibacterial, antivenom, even there are also uses in the cosmetics field. In this study macroscopic and microscopic observation of Snake grass leaves and determination of specific and non-specific standardization on ethanol extracts of Snake grass leaves have been done. The parameters tested on Snake grass leaf extract include the identity of the extract, organoleptic, ethanol soluble extract, water soluble extract, phytochemical screening, chromatogram profile using TLC, spectrum profile using UV-Vis spectrophotometer, spectrum profile using IR (infrared)spectrophotometer, determination of secondary metabolite content, total ash content, water
soluble ash content, acid insoluble ash content, water content, pH, and specific gravity. The results showed the characteristics of ethanol extract of Snake grass leaf in the form of green-black extract, aromatic distinctive odor; ethanol soluble extract content> 54%; water soluble extract content> 37%; phytochemical screening results showed the presence of alkaloid compounds, flavonoids, polyphenols, saponins, steroids and terpenoids; the
results of IR spectrophotometer analysis show spectrum profiles in the range wave of numbers 3325-3351 cm-1, 2924-2919 cm-1, 1622 -1633 cm-1, 1341-1345 cm-1 and 1020-1047 cm-1; total phenol levels> 0.16%; total flavonoid levels> 0.11%; total alkaloid levels> 0.03%; water content
oai:ojs.jurnal.wima.ac.id:article/698
2015-06-19T10:02:21Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/698
2015-06-19T10:02:21Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 2, No 1 (2015)
Observasi Klinik Ramuan Jamu untuk Menurunkan Berat Badan
Pamadyo(, Sunu; Balai Besar Penelitian dan Pengembangan Tanaman Obat dan Obat Tradisional
Novianto, Fajar
Mujahid, Rohmat
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/698
en
The prevalence of overweight (obesity) has increased significantly in the world. During this decade, obesity will
become a health problem. Even today, obesity is referred to as the New World Syndrome, where it is continuity
increasing the number of events almost all over the world. Based on Riskesdas in 2010, the prevalence of adult
obesity in Indonesia had reached 21.7%, significantly increasing if it was compared to the previous Riskesdas
in 2007 which were 10.3%. Obesity in the younger people was associated with the increased of the incident risk
of coronary heart disease, hypertension, hypercholesterolemia, diabetes mellitus and metabolic disorders. Obesity
has a strong correlation with morbidity and mortality, and received serious attention on the causes, prevention
and treatment efforts. Until now, there has been no specific drugs used for weight loss. People saw fitoterapi as
a weight loss (besides diet)drug, because it has been considered relatively safe and without significant side
effects. Jamu consisting of Jati Belanda, Kemuning, Kelembak and tempuyung was used in Saintifikasi Jamu
Clinic. The results in this jamu showed that capsule weight loss has gave lower Body Mass Index (BMI) for 2 months
but it has not lowered the BMI category of overweight to normal. The jamu could significantly reduce the weight
of research subyek after administration for 28 days, with an average decline of 3.9 Kg and a highly significantly
decrease after 56 days administration, with an average decrease of 6.7 Kg, compared to the initial weight.
Medicinal herb could reduce the waist 41.1 cm, after 56 days administration. The herbs could not reduce the upper
arm circumference, after 56 days administration.
oai:ojs.jurnal.wima.ac.id:article/714
2015-10-28T16:51:03Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/714
2015-10-28T16:51:03Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 2, No 2 (2015)
Efek Diuretik Ekstrak Air Kelopak Bunga Rosela (Hibiscus sabdariffa Linn.) pada Tikus Wistar Jantan
Yulinah S, Elin
Wahyuningsih, Sri
Ratna P, Kenah
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/714
en
Telah diteliti efek diuretik ekstrak air kelopak bunga rosela (Hibiscus sabdariffa Linn.) pada tikus jantan Wistar menggunakan metode Lipschitz dengan modifikasi. Dosis yang digunakan untuk ekstrak air kelopak bunga rosela 25, 50, dan 100 mg/kgBB yang diberikan secara oral. Sebagai pembanding adalah furosemid dosis 3,6 mg/kgBB. Parameter yang diamati adalah volume urin kumulatif selama 6 jam dan 24 jam. Hasil penelitian menunjukkan bahwa semua dosis ekstrak air kelopak bunga rosela mempunyai efek diuretik dibandingkan dengan kontrol berbeda bermakna (P≤0,05). Ekstrak air kelopak bunga rosela dosis 50 mg/kgBB juga memiliki sifat saluretik dengan volume urin kumulatif selama 24 jam sebesar 271,406%, sedangkan furosemid dosis 3,6 mg/kgBB sebesar 263,018%; ekskresi ion natrium dan kalium lebih tinggi dibandingkan dengan kontrol maupun pembanding. Ekstrak air kelopak bunga rosela dosis 50 mg/kgBBmenunjukkan efek diuretik yang bersifat saluretik berbeda bermakna terhadap kontrol dan setara dengan pembanding furosemid.
oai:ojs.jurnal.wima.ac.id:article/4578
2024-01-29T05:16:57Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/4578
2024-01-29T05:16:57Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 10, No 2 (2023): October; 86-91
Efektivitas Metode Edukasi Terhadap Tingkat Pengetahuan Masyarakat Tentang Swamedikasi Di Dusun Wonorejo
Purwadi, Faizal Akbar; Akademi Farmasi Indonesia Yogyakarta
Rissa, Mexsi Mutia; Akademi Farmasi Indonesia Yogyakarta
2023-11-16 05:06:09
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/4578
Swamedikasi, Penyuluhan, Intervensi, Pengetahuan
en
World Health Organization mendefinisikan swamedikasi merupakan suatu proses pengobatan yang dilakukan secara mandiri oleh seseorang mulai dari penanganan keluhan hingga pemilihan atau penggunaan obat. Swamedikasi upaya yang paling banyak dilakukan masyarakat sebelum mencari pertolongan ke pusat pelayanan kesehatan. Penelitian ini bertujuan untuk mengetahui pengaruh penyuluhan terhadap pengetahuan masyarakat tentang swamedikasi di dusun Wonorejo. Metode penelitian menggunakan Pre-eksperimental dengan rancangan One Group Pre-test Post-test, dan teknik pengambilan sampel menggunakan metode purposive sampling. Sampel penelitian berjumlah 84 responden yang memenuhi kriteria iklusi. Analisis data menggunakan SPSS 23 dengan uji Wilcoxon. Hasil penelitian menunjukkan bahwa pengetahuan masyarakat tentang swamedikasi sebelum dilakukan penyuluhan kategori baik sebanyak 39 responden (46,42%), pengetahuan cukup 34 responden (40,47%), pengetahuan kurang 11 responden (13,09%), kemudian hasil setelah dilakukan penyuluhan diperoleh pengetahuan baik sebanyak 71 responden (84,53%). Hasil nilai uji statistik diperoleh Asymp. Sig 0,00 kurang dari 0,05. Dapat disimpulkan bahwa penyuluhan berpengaruh dalam meningkatkan pengetahuan masyarakat tentang swamedikasi di Dusu Wonorejo.
oai:ojs.jurnal.wima.ac.id:article/2238
2019-11-04T08:18:01Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/2238
2019-11-04T08:18:01Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 6, No 2 (2019); 98-102
Perbandingan Sintesis Antara Senyawa 2'-Nitrokhalkon dan 2,4-Dimetoksi-2'-Nitrokhalkon dengan Bantuan Iradiasi Gelombang Mikro
Putri, Navyanti Firda; Fakultas Farmasi, Universitas Katolik Widya Mandala, Surabaya
Soewandi, Ami; Fakultas Farmasi, Universitas Katolik Widya Mandala, Surabaya
Budiati, Tutuk; Fakultas Farmasi, Universitas Katolik Widya Mandala, Surabaya
2019-10-31 22:14:29
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/2238
id
The purposes of this research were to find out the influence of a methoxy group to the result percentage reaction and synthesize derivatives of chalcone from derivatives of acetophenone and 2-nitrobenzaldehyde. The purity analysis of the synthesized result was determined by melting point assay and thin layer chromatography, while the identification of the structure was determined by spectrophotometry, infrared pectrophotometry and nuclear magnetic resonance (H-NMR). In the synthesis of compounds formed 3-hydroxy-3- (2-nitrophenyl)-1-fenilpropan-1one and 3-hydroxy-1-(2,4-dimetoksifenil)propan-1-on. The synthesis results obtained an average percentage yield synthesis of 3-hydroxy-3-(2-nitrophenyl)-1-phenylpropan-1-on with the conventional method and with the aid of
microwave irradiation amounted to 60.45% and 32.36%. The percentage results of the synthesis for compounds 3-hydroxy-1-(2,4-dimethoxyphenyl)-3-(2-nitrophenyl)propan-1-on with the conventional method and with the aid of microwave irradiation amounted to 11.51% and 5.57%. The influence of methoxy groups can decrease the reactivity of acetophenone.
oai:ojs.jurnal.wima.ac.id:article/719
2015-10-28T16:51:03Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/719
2015-10-28T16:51:03Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 2, No 2 (2015)
Uji Efek Sedasi dan Durasi Waktu Tidur Ekstrak Etanol Herba Putri Malu (Mimosa microphylla D.) pada Mencit (Mus musculus) Galur Swiss Webster
Muliadi, Yeremia Kevin
Tamayanti, Wahyu Dewi
Soegianto, Lisa
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/719
en
Sejak dahulu tanaman Putri Malu banyak digunakan oleh masyarakat sebagai obat batu ginjal, radang saluran nafas, anti mikroba, peluruh dahak, antipiretik, antiinflamasi, diuretik. Namun, tanaman Putri Malu dengan jenis spesies Mimosa microphylla D. masih jarang dilakukan penelitian serta masih sedikit literatur yang ada, terutama aktivitasnya dalam menimbulkan efek sedasi bila dibandingkan dengan tanaman Putri Malu dari spesies Mimosa pudica L. Oleh sebab itu dilakukan penelitian untuk menguji efek sedasi ekstrak herba Putri Malu (Mimosa microphylla D.) terhadap mencit (Mus musculus) galur Swiss webster untuk mengetahui potensi sedatifnya. Herba Putri Malu Mimosa microphylla D. diekstraksi dengan cara maserasi dengan etanol 96% dan diberikan kepada mencit jantan galur Swiss webster sebanyak 25 ekor yang dibagi dalam 5 kelompok dengan dosis pemberian 600 mg/kgBB, 1200 mg/kgBB, dan 2400 mg/kgBB masing-masing 1 ml/20 gBB. Penelitian ini dilakukan dengan berbagai metode: holeboard, evasion box, platform, rotarod untuk melakukan uji efek sedasi, uji induksi mula tidur, dan uji durasi waktu tidur, serta sebagai pembanding digunakan fenobarbital 30 mg/kgBB. Dari hasil percobaan uji sedatif, diketahui bahwa dosis 600 mg/kgBB ekstrak etanol herba Putri Malu (Mimosa microphylla D.) memiliki aktivitas sedatif terbaik dan pemberian pada 1200 mg/kgBB mampu memperpanjang durasi tidur mencit, namun ekstrak etanol herba Putri Malu (Mimosa microphylla D.) tidak mampu memperpendek waktu mula tidur mencit. Ekstrak etanol herba Putri Malu (Mimosa microphylla D.) memiliki aktivitas dalam menimbulkan efek sedatif, memperpanjang durasi waktu tidur, namun tidak mampu memperpendek waktu mula tidur mencit.
Kata kunci: Mimosa microphylla D., efek sedatif, durasi waktu tidur, waktu mula tidur.
oai:ojs.jurnal.wima.ac.id:article/2344
2020-02-05T14:34:52Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/2344
2020-02-05T14:34:52Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 1, No 1 (2013); 19-24
Pemodelan Interaksi Turunan Potensial Asam Benzoilsalisilat dengan Reseptor Enzim Siklooksigenase-2
Natalia, Ongki; Faculty of Pharmacy, Widya Mandala Catholic University Surabaya
Caroline, Catherine; Faculty of Pharmacy, Widya Mandala Catholic University Surabaya
Soekardjo, Bambang; Faculty of Pharmacy, Widya Mandala Catholic University Surabaya
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/2344
id
The research of synthesize and quantitative structure activity relationship of benzoyl salicylic acid derivatives for analgesic activity in mice had been done by Soekardjo et al. (2009). From the fourteen compounds that
had been synthesized, it has been known that O-(3-chlorometilbenzoyl) salicylic acid had the best analgesic activity (EDso value was 15.7396 mg/kg) while the EDso value of acetyl salicylic acid was 3296 mg/kg. Therefore further studies were carried out to determine the interaction modelling of potential benzoy/saJicyJic acid derivatives with enzyme cyclooxygenase-2 receptor by using Glide (Schrodinger license). The result showed that the GScore of 0-(2-trifluoromethoxybenzoyl)salicylic acid: -9.97, 0-(2.4-dimethylbenzoyl)salicylic acid: -9.94, O-(2-fluorobenzoyl)saJicylic acid : -9.62 and 0-(2.3-dimethy/chlorobenzoyl)salicylic acid : -9.49 more active than O-(3-chloromethylbenzoyl)saJicylic acid (-9.48), which GScore of each compound less than 0-(3-chloromethylbenzoyl)salicylic acid that had been synthesized. 0-(2-trifluoromethoxybenzoyl)salicylic acid, 0-(2.4-dimethylbenzoyl)salicylic acid, O-(2-fluorobenzoyl) salicylic acid and O-(2.3-dimethylchlorobenzoyl) salicylic acid are compounds that have a good potency as an analgesic. Interaction of potential benzoy/salicy/lc acid derivatives with enzyme cyclooxygenase-2 receptor was on residues Tyrosine 385, Leusine 531, Tyrosine 355 dan Arginine 120.
oai:ojs.jurnal.wima.ac.id:article/724
2015-10-28T16:51:04Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/724
2015-10-28T16:51:04Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 2, No 2 (2015)
Aktivitas Imunomodulator Ekstrak n-Heksana, Etil Asetat, dan Metanol Biji Jinten Hitam (Nigella sativa L.)
Prastiwi, Rini
., Kisrini
Iqbal, Anwar
Kristi, Aprina
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/724
en
Jinten hitam (Nigella sativa L.) adalah tanaman yang memiliki aktivitas imunomodulator. Kandungan biji jinten hitam adalah minyak atsiri, alkaloid, saponin, tanin, polifenol dan minyak lemak. Penelitian bertujuan untuk mengetahui efek imunomodulator ekstrak biji jinten hitam dengan parameter fagositosis makrofag dan peningkatan imunoglobulin G. Penelitian menggunakan 30 ekor mencit balb/c yang dibagi ke dalam 6 kelompok. Kelompok I diberi ekstrak n-heksana dengan dosis 1,6843 mg/20 gBB, kelompok II diberi eksrak etil astat dosis 0,2682 mg/20 gBB, kelompok III diberi eksrak metanol dosis 0,4272 mg/20 gBB, kelompok IV kontrol positif menggunakan Imboost® dosis 0,065 mg/20 gBB, kelompok V diberi CMC 0,5%, dan kelompok VI kontrol negatif siklofosfamid dosis 2 mg/20gBB. Ekstrak diberikan selama 21 hari, hari ke-7 dan hari ke-14 masing-masing mencit diinjeksikan SRBC (Sheep Red Blood Cells) intraperitoneal. Pada hari ke-21 darah mencit diambil untuk diambil serumnya, kemudian kadar IgG diperiksa dengan ELISA reader. Fagositosis makrofag dilihat berdasarkan aktivitas dan kapasitas makrofag dari sediaan apus cairan intraperitoneal, dengan menghitung persentase 100 makrofag yang melakukan fagositosis. Kapasitas fagositosis ditetapkan berdasarkan jumlah lateks yang difagositosis oleh 50 makrofag aktif. Hasil yang didapatkan ekstrak biji jinten hitam memiliki potensi sebagai imunomodulator dan ekstrak n-heksana memiliki potensi yang tinggi sebagai imunostimulator diban-dingkan ekstrak lain dengan hasil rata-rata presentasi aktivitas fagositosis makrofag 89,5% dan kapasitas fagositosis makrofag 1204 lateks, begitu juga hasil dengan uji IgG.
Kata kunci: jinten hitam, imunomodulator, IgG, makrofag.
oai:ojs.jurnal.wima.ac.id:article/2391
2022-09-24T02:32:37Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/2391
2022-09-24T02:32:37Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 7, No 1 (2020): Februari; 15-19
Skrining Senyawa Antibakteri dari Minyak Atsiri Rimpang Temu Kunci (Boesenbergia pandurata) terhadap Staphylococcus aureus dengan Metode Bioautografi Kontak
Christiana, Indah; Fakultas Farmasi Universitas Katolik Widya Mandala Surabaya
Soegianto, Lisa; Fakultas Farmasi Universitas Katolik Widya Mandala Surabaya
2020-03-10 00:00:00
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/2391
id
Fingerroot are generally used as a remedy for rheumatism, gastroenteritis, mucositis, diuretic, malaria, bowel disorders, flatulence, skin diseases, diarrhea, mouth sores, and intestinal worms. Essential oils found in Fingerroot are generally used as antibacterial. The purpose of this study is to determine the antibacterial activity of Fingerroot essential oils against Staphylococcus aureus and to determine the antibacterial compound of Fingerroot essential oils (Boesenbergia pandurata) using contact biautography methods. Fingerroot essential oil was obtained by the Stahl distillation method. Determination of the class of efficacious compounds was carried out by contact bioautography method and anisaldehyde-sulfuric acid and vanillin sulfate were used as spray
reagent. The Fingerroot essential oil yields 0.38% and monoterpenes was determined as an antibacterial agent against Staphylococcus aureus.
oai:ojs.jurnal.wima.ac.id:article/2508
2020-10-31T22:36:07Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/2508
2020-10-31T22:36:07Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 7, No 2 (2020): Oktober; 55-63
Review: Sintesis Senyawa Turunan Andrografolid pada Gugus Hidroksil C-14
http://journal.wima.ac.id/index.php/JFST/article/download/2508/6035
Sabila, Rusydina; Padjadjaran University
Megantara, Sandra; Padjadjaran University
Saputri, Febrina Amelia; Padjadjaran University
2020-10-30 00:00:00
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/2508
Andrographolide, hydroxyl group, modification
Fakultas Farmasi, Universitas Padjadjaran
en
Andrografolid merupakan suatu diterpenoid lakton yang terkandung dalam tanaman sambiloto (Andrographis paniculata) sebagai senyawa aktif utama. Andrografolid memiliki banyak aktivitas biologis, diantaranya sebagai antiinflamasi, antikanker, hepatoprotektor, antioksidan, antidiabetes, antihiperlipidemia, antibakteri, dan antivirus. Untuk meningkatkan sifat fisikokimia dan mengoptimalkan aktivitas terapeutik dari andrografolid, diperlukan modifikasi struktur andrografolid. Pada review ini akan dibahas mengenai metode yang dapat dilakukan dalam memodifikasi struktur andrografolid terutama pada gugus hidroksil C-14 dan membandingkan potensi dari aktivitas biologisnya setelah dimodifikasi. Terdapat dua metode modifikasi yaitu dengan cara memproteksi gugus hidroksil C-3 dan C-19 terlebih dahulu untuk menghasilkan senyawa 3,19-isopropiliden andrografolid yang kuat terhadap serangan nukleofil dan cara kedua yaitu langsung mereaksikannya dengan klorida asam dengan bantuan amina tersier seperti trietilamin dan piridin. Dari hasil review didapatkan bahwa modifikasi terhadap gugus hidroksil C-14 dapat meningkatkan potensi aktivitas biologis andrografolid dan metode yang paling baik untuk memodifikasi andrografolid pada gugus hidroksil C-14 yaitu dengan cara memproteksi gugus hidroksil C-3 dan C-19 terlebih dahulu serta mereaksikannya dengan klorida asam atau anhidrida asam agar diperoleh rendemen yang lebih banyak.
oai:ojs.jurnal.wima.ac.id:article/811
2016-06-08T14:50:07Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/811
2016-06-08T14:50:07Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 2, No 1 (2015)
Studi Klinik Efek Ramuan Jamu untuk Insomnia terhadap Fungsi Ginjal Pasien Klinik Hortus Medicus
Astana, Widhi
Ardianto, Danang
Triyono, Agus
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/811
en
Ginjal adalah organ yang sering terganggu karena pemberian obat-obatan. Efek samping obat
tradisional terhadap
ginjal masih sangat sedikit diketahui bukti ilmiahnya. Salah satu obat tradisional yang sering
digunakan adalah sebagai sedatif. Sebuah penelitian diadakan di Balai Besar Litbang Tanaman Obat
dan Obat Tradisional (B2P2TOOT) tahun 2013 untuk mengetahui perubahan terhadap fungsi ginjal
pasien-pasien yang mendapatkan terapi ramuan jamu insomnia. Metode penelitian berupa observasi
terhadap 30 pasien insomnia yang datang dan berobat di Klinik Saintifikasi Jamu Hortus Medicus.
Pasien insomnia yang mendapat terapi ramuan jamu selama 14 hari diobservasi fungsi ginjalnya.
Evaluasi dilakukan pada nilai laboratoris yang merepresentasikan fungsi ginjal (ureum dan
kreatinin) pada hari ke-0 dan hari ke-14. Perbandingan hasil pemeriksaan sebelum dan sesudah terapi
menggambarkan bahwa terdapat penurunan kadar ureum yang signifikan (p0,05). Semua subyek memiliki nilai ureum
dan kreatinin yang normal secara laboratoris. Pemberian ramuan jamu untuk insomnia tidak
mengganggu fungsi ginjal.
oai:ojs.jurnal.wima.ac.id:article/2792
2020-10-31T22:36:09Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/2792
2020-10-31T22:36:09Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 7, No 2 (2020): Oktober; 74-80
Formulasi Ekstrak Kering Kulit Buah Delima (Punica granatum L.) Sebagai Masker Wajah dalam Bentuk Peel-Off Gel
Wattimena, Jeane Hobertina; Fakultas Farmasi, Universitas Katolik Widya Mandala Surabaya
Darsono, Farida L.; Fakultas Farmasi, Universitas Katolik Widya Mandala Surabaya
Hermanu, Liliek S.; Fakultas Farmasi, Universitas Katolik Widya Mandala Surabaya
2020-10-30 00:00:00
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/2792
Punica granatum L.; face mask; peel-off; tannin.
in
Kulit wajah memerlukan pemeliharaan yang khusus karena kulit wajah merupakan organ yang sensitif terhadap perlakuan dan rangsangan. Berbagai faktor lingkungan seperti cuaca, kosmetik, makanan obat-obatan, serta faktor stres dan kelelahan dapat menjadi penyebab gangguan kesehatan kulit wajah. Salah satu cara untuk mengatasi masalah kesehatan kulit adalah dengan menggunakan sediaan kosmetik perawatan wajah (skin
care) yaitu masker wajah. Bahan alam yang dapat digunakan adalah delima (Punica granatum L.). Kandungan tanin pada kulit buah delima berfungsi sebagai adstrigensia yang banyak digunakan sebagai pengencang kulit dalam kosmetik. Penelitian ini bertujuan untuk melihat pengaruh peningkatan konsentrasi ekstrak kering kulit buah delima terhadap mutu fisik, efektivitas dan keamanan sediaan masker wajah dalam bentuk gel peel-off. Konsentrasi yang digunakan adalah 10%, 15% dan 20%. Hasil penelitian menunjukan bahwa peningkatan konsentrasi ekstrak kering kulit buah delima (Punica granatum L.) mempengaruhi hasil uji secara signifikan,
terhadap hasil uji mutu fisik sediaan yaitu pH, viskositas dan daya sebar; efektivitas sediaan yaitu waktu kering, kekencangan masker, elastisitas lapisan film dan kemudahan dibersihkan serta stabilitas sediaan yaitu stabilitas pH dan viskositas dari sediaan masker wajah bentuk gel peel-off. Sediaan yang terbaik adalah sediaan dengan konsentrasi ekstrak 10%.
oai:ojs.jurnal.wima.ac.id:article/2008
2019-10-14T10:40:55Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/2008
2019-10-14T10:40:55Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 6, No 1 (2019); 18-25
Optimasi Sediaan Pelembab Ekstrak Kering Kulit Buah Manggis (Garcinia mangostana L.) dengan Kombinasi Asam Stearat dan Trietanolamin sebagai Emulgator
Chomariyah, Nur; Fakultas Farmasi Universitas Katolik Widya Mandala, Surabaya
Darsono, Farida Lanawati; Fakultas Farmasi Universitas Katolik Widya Mandala, Surabaya
Wijaya, Sumi; Fakultas Farmasi Universitas Katolik Widya Mandala, Surabaya
2019-04-23 14:17:18
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/2008
id
Mangosteen is a plant which has a high antioxidant activity. The mangosteen pericarp contains antioxidant compound alpha mangosteen. Beside as an antioxidant, alpha-mangosteen has the potential as skin moisturizer, which gives protection for dry skin condition. The purpose of this research was to know the influence a combination stearic acid and trietanolamin on the physical characteristics and effectiveness. As the results of this researchs optimum formula was obtained using factorial design expert. The formula divided into 4 groups, formula A 10% of stearic acid and 0.1% trietanolamine, formula B was 16% of staric acid and 0.1% trietanolamine, formula C 10% of stearic acid and 0.5% trietanolamine and formula D 16% of stearic acid and 0.5% trietanolamine. Effectiveness and physical quality results were analyzed using one way anova and post hoc tukey with the level of confidence 95%. The results showed that stearic acid as an emulsifying agent have significant effect on the decrease of spreadibility, effectiveness and an increase in pH, viscosity, stickiness and ease for removal. Triethanolamin as an emulsifying agent had significant effect on them decrease of spreadibility, effectiveness and an increase in pH, viscosity, stickiness, and ease for removal. Interaction of both agents had signifficant effect to increase pH, viscosity, and effectiveness and a decrease in spreadibility, stickiness, and ease to removal of moisturizing cream containing the extract mangosteen pericarp. Optimum formula of moisturizing cream dry extract of mangosteen pericarp was obtained, a combination of 14.02% stearic acid and 0.41% trietanolamine as an anionic emulsifying agents.
oai:ojs.jurnal.wima.ac.id:article/2979
2022-09-24T02:31:56Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/2979
2022-09-24T02:31:56Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 8, No 1 (2021): Februari; 34-40
Formulasi Tablet Effervescent Ekstrak Daun Katuk (Saoropus androgynous L. Merr.) dengan Variasi Konsentrasi Asam dan Basa
http://journal.wima.ac.id/index.php/JFST/article/download/2979/7330
Yulianti, Dimas Ayu; Universitas Negeri Surabaya
Sutoyo, Suyatno; Universitas Negeri Surabaya
2021-03-21 11:41:12
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/2979
Tablet effervescent, ekstrak daun katuk, asam sitrat, asam tartrat, natrium bikarbonat
ind
Katuk merupakan salah satu jenis tanaman obat tradisional yang bagian daunya dipercaya oleh masyarakat Indonesia dapat memperlancar air susu ibu (ASI). Penelitian ini bertujuan untuk memperoleh formula terbaik tablet effervescent dari ekstrak daun katuk dengan variasi konsentrasi kombinasi sumber asam dan basa. Sumber asam yang digunakan terdiri dari asam sitrat dan asam tartrat, sedangkan natrium bikarbonat digunakan sebagai sumber basa. Variasi yang dilakukan yaitu membuat empat formula dengan konsentrasi asam basa sebesar 45%, 50%, 55%, dan 60%. Metode yang digunakan dalam pembuatan tablet adalah granulasi basah. Tablet yang dihasilkan dievaluasi mutu fisiknya meliputi uji keseragaman bobot, kadar air, kekerasan tablet, kerapuhan tablet, waktu larut, derajat keasaman (pH), serta uji organoleptik terhadap 20 responden. Uji organoleptik meliputi rasa, aroma, bentuk dan warna tablet. Hasil penelitian menunjukkan tablet effervescent ekstrak daun katuk dengan formulasi asam basa sebesar 60% (F-4) merupakan formula terbaik karena memenuhi semua persyaratan mutu fisik tablet effervescent serta menunjukkan tingkat kesukaan yang tertinggi pada uji organoleptik
oai:ojs.jurnal.wima.ac.id:article/2013
2019-10-14T10:40:55Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/2013
2019-10-14T10:40:55Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 6, No 1 (2019); 51-58
Formulasi Sediaan Krim Pelembab Ekstrak Air Buah Pepaya (Carica Papaya L.)
Ningsih, Kadek Sri Utami; Fakultas Farmasi, Universitas Katolik Widya Mandala Surabaya
Darsono, Farida Lanawati; Fakultas Farmasi, Universitas Katolik Widya Mandala Surabaya
Wijaya, Sumi; Fakultas Farmasi, Universitas Katolik Widya Mandala Surabaya
2019-04-23 14:17:22
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/2013
id
Sucrose in papaya fruit was used as a moisturizer because it has worked as humectants, which reduce water evaporation on the surface of the skin. The purpose of this research was to determine the effect of the increasing concentrations of water extract of papaya fruit to evaluate its physical quality, effectiveness, safety, acceptability, and stability of the moisturizing cream water extract of papaya (Carica papaya L.). In this study, it used 3 formulas containing the extract of papaya fruit at concentration of 10% (formula 1), 20% (formula 2), 30% (formula 3), also blank containing base only, and base without extract and without moisturizing agent. The physical quality tests include organoleptic, pH, viscosity test, emulsion type test, dispersive power test, homogeneity, water washed power and adhesion test. The effectiveness of mouisturizer effect on the skin was tested with in vitro method: Sorption Desorption Test. Savety testing include irritation test and acceptability test. The data was analyzed using oneway ANOVA then continued with post hoc Tukey. The results showed that the increasing concentrations of the extract provides significant effect on efectivity, wherein the greater the concentration of water extract of papaya fruit (Carica papaya L.) were added, then the higher the ability to moisturize the skin and produce of moisturizer cream with pH test 6.04, viscosity 159710 cps, dispersive power 3.63 cm, water washed power 13.48 ml, adhesion 6005 second, and moisturizer cream stable during storage. The best formula is the formula 3 with a concentration extract of 30%.
oai:ojs.jurnal.wima.ac.id:article/2925
2021-11-26T14:50:54Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/2925
2021-11-26T14:50:54Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 8, No 2 (2021): Oktober; 54-61
Pengaruh Efek Samping Obat Off Label terhadap Kualitas Hidup Pasien Lupus di RSUD Ulin Banjarmasin
Yuwindry, Iwan; Sari Mulia University
Noval, Noval; Sari Mulia University
2021-11-26 15:50:48
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/2925
Lupus, Off Label, Efek Samping, Kualitas Hidup, Autoimun
Direktorat Jenderal Pendidikan Tinggi Kementerian Pendidikan dan Kebudayaan Republik Indonesia
ind
Lupus Eritematosus Sistemik merupakan penyakit inflamasi autoimun kronis yang belum jelas penyebabnya, memiliki variasi gambaran klinis yang luas dan tampilan perjalanan penyakit yang beragam. Penggunaan obat-obatan off label seperti kortikosteroid untuk pengobatan SLE dapat mengakibatkan potensi efek samping yang besar terhadap pasien Lupus. Penelitian ini bertujuan untuk mengetahui pengaruh efek samping penggunaan obat-obatan off label terhadap kualitas hidup pasien lupus, mengetahui tingkat efek samping penggunaan obat-obatan off label serta mengetahui tingkat kualitas hidup pasien lupus. Penelitian ini dilakukan menggunakan metode potong lintang (cross sectional) dengan cara survey menggunakan intrumen Algoritma Naranjo dan instrumen kuesioner Quality of Life (WHOQOL)–BREF dengan responden pada penelitian ini berjumlah 28 responden. Berdasarkan hasil penelitian didapatkan bahwa penggunaan obat-obatan off label pada terapi lupus dapat memunculkan resiko kemungkinan besar terjadinya reaksi obat merugikan (ROM). Kualitas hidup yang didapatkan dalam penelitian ini menunjukkan hasil bahwa tingkat kualitas hidup responden masuk dalam kategori baik. Hasil analisis pada penelitan ini menyatakan bahwa efek samping penggunaan obat-obatan off label tidak mempunyai hubungan yang signifikan terhadap kualitas hidup pada pasien lupus atau dalam kata lain tidak ada pengaruh efek samping penggunaan obat-obatan off label terhadap kualitas hidup pasien lupus. Data penelitian menunjukkan nilai r hitung (pearson correlations) adalah -0,016 dan nilai Sig (2-tailed) adalah 0,936. Hasil analisis pengaruh efek samping penggunaan obat-obatan off label terhadap kualitas hidup pada pasien lupus sangat jelas menggambarkan bahwa tidak ada hubungan signifikan antara efek samping penggunaan obat-obatan off label terhadap kualitas hidup pasien lupus, namun pada korelasi ini terdapat hubungan yang tidak searah, dimana apabila nilai efek samping yang dialami responden tinggi maka nilai kualitas hidup responden justru rendah. Sebaliknya apabila nilai efek samping yang dialami responden rendah maka nilai kualitas hidup responden akan tinggi.
oai:ojs.jurnal.wima.ac.id:article/2052
2019-05-23T12:42:38Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/2052
2019-05-23T12:42:38Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 5, No 1 (2018); 23-29
Uji Aktivitas Antimikroba Ekstrak Etanol Daun Cayratia trifolia terhadap Staphylococcus aureus dan Candida albicans
Sari, Rizki Sari Endah; Fakultas Farmasi, Universitas Katolik Widya Mandala Surabaya
Soegianto, Lisa; Fakultas Farmasi, Universitas Katolik Widya Mandala Surabaya
Hermanu, Liliek S,; Fakultas Farmasi, Universitas Katolik Widya Mandala Surabaya
2018-05-23 00:00:00
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/2052
id
Cayratia trifolia is a wild plant that is easily found in the lowlands, tropical and subtropical regions. Cayratia trifolia is known to be efficacious as an antibacterial, antifungal, antiprotozoa, hypoglycemia, anticancer and diuretic. This study aims to determine whether the ethanol extract of Cayratia trifolia leaves has antimicrobial activity against Candida albicans and Staphylococcus aureus using well diffusion method; to determine the value of the Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) using microdilution method; and to determine the secondary metabolite groups which have antimicrobial activity against Staphylococcus aureus and Candida albicans. In this study bioautography method was carried out to determine the secondary metabolite group that can inhibit microbial growth. Ethanol extract of Cayratia trifolia (Galing-galing) leaves has no antimicrobial activity against Candida albicans. The MIC value of the ethanol extract of Cayratia trifolia (Galing-galing) leaves against Staphylococcus aureus is at a concentration of 125 ppm, while the MBCvalue is at a concentration of 250 ppm. The group of compounds that have antibacterial activity against Staphylococcus aureus is polyphenol, meanwhile flavonoid suspected has activity against Candida albicans.
oai:ojs.jurnal.wima.ac.id:article/3365
2021-11-26T14:50:54Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/3365
2021-11-26T14:50:54Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 8, No 2 (2021): Oktober; 91-100
Studi Literatur: Agen Antivirus pada Pasien COVID-19 dengan Penyakit Ginjal Kronis
Meiliana, Made Laksmi; Universitas Airlangga
Hasmono, Didik; Universitas Airlangga
2021-11-26 15:50:49
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/3365
COVID-19; chronic kidney disease; antiviral
in
At the end of 2019, Wuhan, Hubei Province, reported the first case of a virus similar to pneumonia. The World Health Organization (WHO) reports this outbreak as the Corona virus (COVID-19). Infection with COVID-19 may be more common in people who have chronic kidney disease (CKD). Patients with chronic kidney failure may experience infectious complications due to a weakened immune system and immunosuppressive state. Similarly, they suffer from a chronic systemic inflammatory state, which can contribute to increased morbidity and mortality. Thus, the purpose of this study is to conduct a review of antiviral agents and to summarize recommended antiviral regimens in COVID-19 patients with chronic kidney disease. This article search used Mendeley, Google Scholar, ScienceDirect, and PubMed from the NCBI database in October 2020. The administration of drugs to patients with chronic kidney disease who have been exposed to COVID-19 must be seriously considered. Certain antivirals must be adjusted to avoid deteriorating the patient's kidney condition. Antiviral agents are medications used to treat and prevent COVID-19 infection. Numerous antiviral agents, including ramdesivir, ribavirin, hydroxychloroquine or chloroquine, and umifenovir, must be administered with caution and dose adjustments as necessary in CKD patients exposed to COVID-19.
oai:ojs.jurnal.wima.ac.id:article/2137
2019-09-13T14:01:12Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/2137
2019-09-13T14:01:12Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 5, No 2 (2018); 59-63
Pola Penggunaan Antihipertensi pada Pasien Diabetes Mellitus Tipe 2 di Poli Penyakit Dalam RS Bhayangkara Surabaya
Pramadani, Yana; Fakultas Farmasi Universitas Katolik Widya Mandala Surabaya
Hasmono, Didik; RS Bhayangkara Surabaya and Fakultas Farmasi, Universitas Airlangga Surabaya
Kasih, Elisabeth; Fakultas Farmasi, Universitas Katolik Widya Mandala Surabaya
Hartono, Ruddy; RS Bhayangkara Surabaya
2019-09-13 16:01:02
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/2137
id
Diabetes mellitus (DM) is a metabolic disease characterized by symptoms of hyperglycemia. This disease can be caused due to abnormalities in insulin secretion, insulin action or both. Management of diabetes mellitus in general is to improve the quality of life of people with diabetes, namely to eliminate complaints of diabetes mellitus, improve quality of life, and reduce the risk of acute complications; to achieve this goal their blood pressure must be controlled using antihypertensive therapy. The purpose of this study was to examine the pattern of antihypertensive drug use related to the type, dose, and frequency of administration in reducing blood pressure in patients with type 2 diabetes mellitus in the internal medicine clinic of Bhayangkara Hospital Surabaya. The method of this study was observational because researchers did not provide treatment directly to patients. Data were collected retrospectively between August 1 and September 15, 2015. The results showed 80 patients (48%) used single therapy and 86 patients (52%) used combination therapy. The antihypertensive drug that is often used as a single therapy is valsartan (1x80 mg) given orally in 16 patients (20%) and as a combination is valsartan (1x80 mg) + amlodipine (1x10 mg).
oai:ojs.jurnal.wima.ac.id:article/2142
2019-09-13T14:01:12Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/2142
2019-09-13T14:01:12Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 5, No 2 (2018); 94-99
Pola Penggunaan Levofloxacin pada Pasien HIV dan AIDS di UPIPI RSUD DR. Soetomo Surabaya
Pambudi, Rien Esti; Fakultas Farmasi, Universitas Katolik Widya Mandala Surabaya
Triyono, Erwin Astha
Surdijati, Siti; Fakultas Farmasi, Universitas Katolik Widya Mandala Surabaya
Jaya, Halim Priyahau; RSUD Dr. Soetomo Surabaya
2019-09-13 16:01:02
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/2142
id
HIV is a retrovirus (RNA) that attacks the human immune system. AIDS is a retrovirus disease characterized by immunosuppression which causes opportunistic infectious diseases. Opportunistic infections appear with new
forms of infection by other microorganisms or reactivation of latent infections under normal conditions that can be controlled by the immune system so as not to cause manifestations. Opportunistic infections show effects on immunity associated with CD4 cell counts. The therapy used to reduce opportunistic infections is levofloxacin. Based on research, levofloxacin for HIV AIDS patients is often used to reduce opportunistic infections including bacterial pneumonia, tuberculosis and sepsis. This study aims to provide data that includes levofloxacin therapeutic doses, frequency use, old route drugs, prevalence and interaction of qualitative analysis related to medical records in HIV & AIDS patients at UPIPI DR. Soetomo Regional General Hospital Surabaya. The research method used is a retrospective observational study on medical records of patients with HIV & AIDS. Sampling was done by consecutive sampling in the period January 1, 2015 to June 30, 2015. The results obtained from the most relevant types of research, dose, frequency and route were levofloxacin for the treatment of opportunistic infections, especially bacterial pneumonia, tuberculosis, and sepsis. in oral doses and injections at a dose of 500 mg and a frequency of 750 mg 1x1. The use of levofloxacin given to HIV & AIDS patients at UPIPI DR. Surabaya Soetomo Regional General Hospital, related to dosage, route, frequency, interval, and duration of administration is in accordance with existing guidelines.
oai:ojs.jurnal.wima.ac.id:article/3027
2023-04-12T02:22:58Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/3027
2023-04-12T02:22:58Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 9, No 1 (2022): Februari; 30-34
Pengaruh Pemberian Perasan Lobak Putih (Raphanus sativus L.) dan Bengkuang (Pachyrhizus erosus L.) terhadap Kadar Glukosa Darah pada Mencit Model Diabetes
Pertiwi, Reza; Universitas Bengkulu
Khodijah, Petri Siti; Universitas Bengkulu
Aniza, Mifta Violina; Universitas Bengkulu
Kurniawati, Noval; Universitas Bengkulu
Kurniati, Eni; Universitas Bengkulu
Handayani, Dian; Universitas Bengkulu
Lestari, Dian Fita; Universitas Bengkulu
Notriawan, Doni; Universitas Bengkulu
2022-03-30 00:00:00
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/3027
lobak putih, bengkuang, glukosa darah, antidiabetes
en
Kadar glukosa darah adalah jumlah kandungan glukosa yang ada pada plasma darah. Pengukuran kadar glukosa darah puasa merupakan salah satu metode untuk mengidentifikasi penyakit diabetes melitus pada seseorang. Bengkuang memiliki serat larut air yang dapat memperlambat absorpsi glukosa sehingga dapat menurunkan kadar glukosa darah. Lobak putih memiliki kesamaan jenis dengan bengkuang yaitu merupakan jenis tanaman umbi yang diharapkan memiliki efek yang sama dalam menurunkan kadar glukosa darah. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian perasan lobak putih dan bengkuang terhadap kadar glukosa darah mencit yang diinduksi aloksan sebagai model diabetes. Mencit dibagi menjadi 8 kelompok dengan pembagian secara random dan dipuasakan selama 8 jam, pada hari ke–0 diukur kadar glukosa darahnya sebagai kadar glukosa darah awal. Kelompok I sebagai kontrol normal yang tidak diberi induksi aloksan dan diberi aquades. Pada kelompok II-VI, mencit diinduksi aloksan dengan dosis 200 mg/kg BB secara intraperitoneal. Setelah aloksan diinduksikan, diukur kadar glukosa darah mencit pada hari ke-3. Setelah didapati kadar glukosa darah mencit yang tinggi, kelompok mencit II diberi aquades, kelompok III diberi glibenklamid 0,013 mg/20 gBB mencit, kelompok IV diberi perasan lobak putih 0,1 ml/20 gBB, kelompok V diberi perasan lobak putih dan bengkuang 2:1, kelompok VI diberi perasan lobak putih dan bengkuang 1:1, kelompok VII diberi perasan lobak putih dan bengkuang 1:2, kelompok VIII diberi perasan bengkuang 0,1 ml/20 gBB. Pemberian perasan lobak putih dan bengkuang dapat menurunkan kadar glukosa darah.
oai:ojs.jurnal.wima.ac.id:article/2173
2019-10-14T10:20:12Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/2173
2019-10-14T10:20:12Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 4, No 1 (2017); 11-17
Penggunaan Carbormer 940 sebagai Gelling Agent dalam Formula Pasta Gigi Ekstrak Buah Apel (Malus sylvestris Mill) dalam Bentuk Gel
Wijayanti, Luh Putu Widiasih; Fakultas Farmasi, Universitas Katolik Widya Mandala Surabaya
Darsono, Farida Lanawati; Fakultas Farmasi, Universitas Katolik Widya Mandala Surabaya
Ervina, Martha; Fakultas Farmasi, Universitas Katolik Widya Mandala Surabaya
2019-10-14 12:20:06
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/2173
id
Teeth are often not protected from several diseases, despite having a hard structure. Dental diseases include dental caries (cavities) and diseases of the tooth supporting tissues. Dental caries is defined as a disease that
results in damage to the hard tissue of the tooth structure through the process of demineralization. Streptococcus mutans is known as a major microorganism that plays a role in the process of dental caries. One way to reduce the formation of dental caries is to use toothpaste. Apples (Malus sylvestris Mill) Manalagi variety that has catechins, has efficacy as an anti dental caries. The purpose of this study was to formulate ethanol extract from apples as a gel toothpaste using carbomer 940 as a gelling agent. Apple ethanol extract used in this study was 9.6%, while the carbomer concentration of 940 used was 0.75% (formula I), 1.0% (formula II) and 1.5% (formula III). Evaluation of toothpaste formulas includes physical quality including organoleptic, homogeneity, pH, viscosity, dispersibility. Characteristic evaluation includes ease of release from the tube, adhesion and consistency. The stability evaluation includes room temperature stability, high temperature, and cycling tests. Evaluation of aseptability and evaluation of irritation is done in cow's jaws. Increasing the concentration of Carbomer 940 as a gelling agent has a significant effect on viscosity, dispersion, ease of release from the tube, adhesion and consistency. The test results show formula 3 (1.5% carbomer 940) is the best formula because it has produced physical quality in accordance with specifications, the resulting preparation is stable and very preferred and safe to use.
oai:ojs.jurnal.wima.ac.id:article/3776
2023-03-15T14:35:06Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/3776
2023-03-15T14:35:06Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 9, No 2 (2022): October; 53-59
Uji Aktivitas Antidiabetes Kombinasi Ekstrak Etanol Bunga Turi Merah (Sesbania grandiflora L.) dan Bunga Telang (Clitoria ternatea L.) secara In Vitro
http://journal.wima.ac.id/index.php/JFST/article/download/3776/9851
Anggaraini, Devina Ingrid; Sekolah Tinggi Ilmu Kesehatan Nasional
Kusuma, Eka Wisnu; Sekolah Tinggi Ilmu Kesehatan Nasional
Murti, Nurul Retno; Sekolah Tinggi Ilmu Kesehatan Nasional
2022-11-16 00:00:00
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/3776
antidiabetes, EC50, nelson-somogyi, bunga telang, bunga turi merah
en
Diabetes melitus merupakan salah satu penyakit comorbid yang dapat memperparah kondisi pasien Covid-19. Terdapat berbagai pengobatan dari bahan alam yang dapat membantu dalam penurunan dan pengontrol kadar gula darah. Penelitian ini bertujuan untuk mengetahui adakah aktivitas antidiabetes kombinasi ekstrak etanol bunga telang (Clitoria ternatea L.) dan bunga turi merah (Sesbania grandiflora L.) serta mengetahui nilai aktivitas antidiabetes kombinasi ekstrak etanol bunga telang (Clitoria ternatea L.) dan bunga turi merah (Sesbania grandiflora L.) dibanding ekstrak tunggal. Penelitian dimulai dengan ekstraksi, uji kualitatif, dan uji aktivitas antidiabetes menggunakan metode Nelson-Somogyi dengan spektrofotometer UV-Vis. Penelitian menggunakan empat kombinasi konsentrasi ekstrak etanol bunga telang dan bunga turi merah dengan perbandingan 1:0; 1:2; 2:1; 0:1. Hasil menunjukkan kombinasi konsentrasi ekstrak etanol bunga telang dan bunga turi merah perbandingan 2:1 dengan EC50 sebesar 13,5436 ppm memiliki aktivitas antidiabetes paling optimal dan lebih efektif daripada ekstrak tunggal bunga turi merah dengan nilai EC50 sebesar 13,7350 ppm dan ekstrak tunggal bunga telang dengan nilai EC50 sebesar 13,6929 ppm
oai:ojs.jurnal.wima.ac.id:article/2178
2019-10-14T10:20:12Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/2178
2019-10-14T10:20:12Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 4, No 1 (2017); 44-49
Standarisasi Spesifik dan Non Spesifik dari Ekstrak Etanol Daun Beluntas (Pluchea indica L. Less.)
Wijaya, Sumi; Fakultas Farmasi Universitas Katolik Widya Mandala Surabaya
Setiawan, Henry Kurnia; Fakultas Farmasi Universitas Katolik Widya Mandala Surabaya
Ano, Lucyanna Ayu Lestari; Fakultas Farmasi Universitas Katolik Widya Mandala Surabaya
2019-10-14 12:20:06
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/2178
id
Indian fleabane (Pluchea indica (L.) Less.), on of the species in Asteraceae family, is widely used for traditional medicine. A standardization process is needed as an effort to improve the quality and safety of products, so that it
is expected to increase the trust in drugs derived from natural ingredients. This study aims to determine the morphology and anatomy of Indian fleabane leaves and to determine the standardization value of the ethanol
extract of Indian fleabane leaves. Dried powder of Indian fleabane leaves are obtained from three different regions (Bogor, Malang and Surabaya). The extract was obtained by maceration method using 96% ethanol as a
solvent. Specific standardization includes identity, macroscopic, determination of soluble extract, phytochemical screening, TLC (Thin Layer Chromatography) pattern determination, determination of infrared spectrum profile, determination of UV-Vis spectrum profile, and determination of flavonoid, phenol and alkaloid total content. Nonspecific standardization includes determination of total ash content, water soluble ash content, acid insoluble ash content, drying losses, specific gravity and pH. Organoleptic observations showed the ethanol extract of Indian fleabane leaves has blackish brown and aromatic odour. The mobile phase being used for TLC profile chromatogram was n-hexane: ethyl acetate (7: 3). Based on the results, the screening results of Indian fleabane contain alkaloids, flavonoids, polyphenols, tannins, saponins, steroids and triterpenoids. The Infra red spectrophotometer analysis showed the range of wave numbers of 2924 - 2925, 1515 - 1516, 1259 - 1260, 1159 - 1162, 1112 - 1115, 1046 - 1048, 811 - 812, 505 - 506 and 452 - 454 cm- 1. The standardization value of Indian fleabane ethanol extract showed ethanol soluble extract> 65%, water soluble extract> 49%, water content
oai:ojs.jurnal.wima.ac.id:article/4557
2023-03-15T14:35:07Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/4557
2023-03-15T14:35:07Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 9, No 2 (2022): October; 94-98
Analisa Vitamin B1, B6 dan B12 Secara Simultan Dengan Metode Kromatografi Pasangan Ion
Diana, Diana; Widya Mandala Surabaya Catholic University
2022-10-30 00:00:00
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/4557
validation; ion pair; HPLC; B complex
en
Kromatografi pasangan ion dapat digunakan untuk meretensi senyawa yang memiliki muatan, bersifat polar dan memisahkan analit yang bervariasi kepolaran dan hidrofobisitasnya. Hal yang tidak dapat dilakukan dengan mudah pada metode kromatografi fase balik biasa. Pemisahan senyawa pada kolom menggunakan kromatografi pasangan ion dilakukan untuk menganalisa kadar Thiamine Mononitrat (Vitamin B1), Pyridoxine HCl (Vitamin B6) dan Cyanocobalamin (Vitamin B12) secara simultan. Validasi juga dilakukan untuk membuktikan performa metode analisa yang diusulkan. Dari penelitian ini dibuktikan bahwa kromatografi pasangan ion dapat menjadi metode alternatif yang lebih efisien untuk menganalisa sediaan tablet oral dengan kandungan B1, B6 dan B12.
oai:ojs.jurnal.wima.ac.id:article/4566
2023-08-06T16:20:07Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/4566
2023-08-06T16:20:07Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 10, No 1 (2023): February; 32-37
Pengaruh Garam Krayan terhadap Bakteri Cairan Sulkus Gingiva Anak dengan Gingivitis Ringan (Kajian pada Streptococcus alpha)
Prathiwi, Caecilia Dewi Ratna; Universitas Gadjah Mada
Utomo, Rinaldi Budi; universitas Gadjah Mada
Wardhani, Putri Kusuma; gadjah mada university
2023-05-21 03:15:47
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/4566
Garam Krayan, gingivitis ringan, Streptococcus alfa, zona hambat
idn
Latar belakang: gingivitis adalah Penyakit periodontal paling sering terjadi pada anak-anak. Streptococcus alpha (S. alpha) adalah bakteri yang paling sering ditemukan pada gingivitis anak. Pertumbuhan bakteri patogen dalam rongga mulut dapat dicegah dengan Antibakteri. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh larutan garam Krayan pada bakteri yang ditemukan pada cairan sulkus gingiva terutama S.alpha.Metode: penelitian ini adalah ekperimental laboratorium. Streptococcus alpha diperoleh dari isolasi dari cairan sulkus gingiva anak dengan gingivitis ringan. Garam Krayan diperoleh dari pegunungan Krayan di Kalimantan Utara. Konsentrasi larutan yang digunakan adalah 20%, 25%, 30%, 35% dan 40%. Hambatan pertumbuhan garam Krayan terhadap S. alpha dihitung dengan menggunakan zona hambatan pada agar Mueller Hinton yang ditambahkan agar darah domba. Uji statistik penelitian ini menggunakan uji One Way Anova.Hasil: hasil penelitian menunjukkan bahwa larutan garam Krayan 20% memiliki diameter zona hambat 12.380 ± .22550mm, konsentrasi 25% 13,568 ± .11122, konsentrasi 30% 14,578 ± .12337, konsentrasi 35% 19,400 ± .12550 dan konsentrasi 40% 21,130 ± .04743mm. Hasil uji statistik menunjukkan adanya perbedaan yang signifikan di seluruh kelompok perlakuan.Kesimpulan: garam Krayan memiliki pengaruh daya hambat terhadap pertumbuhan S. alpha. Semakin besar konsentrasi larutan garam semakin besar pula hambatan yang dihasilkan.
oai:ojs.jurnal.wima.ac.id:article/2183
2019-10-14T11:39:53Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/2183
2019-10-14T11:39:53Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 4, No 2 (2017); 76-81
Uji Potensi Antibakteri dan Antibiofilm Minyak Atsiri Umbi Teki (Cyperus rotundus L.) terhadap Staphylococcus aureus ATCC 6538
Uthari, Ni Made; Fakultas Farmasi, Universitas Katolik Widya Mandala Surabaya
Soegianto, Lisa; Fakultas Farmasi, Universitas Katolik Widya Mandala Surabaya
Hermanu, Liliek S.; Fakultas Farmasi, Universitas Katolik Widya Mandala Surabaya
2019-10-14 12:31:26
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/2183
id
Infectious disease is a disease that is caused by an invasion of pathogenic microorganisms in the body. Biofilm is a group of microorganisms that are able to differentiate and proliferate in the complex way as well as being able to communicate between cells through a matrix of polysaccharides. In chronic infection, biofilm has an important role to maintain the bacteria which can cause resistance to antibiotics. Teki (Cyperus rotundus L.) is one of the plants that has many benefits for different treatment. The aim of this study was to determine the antibacterial activity and inhibition of biofilm activity of essential oil of Cyperus rotundus L. tubers against Staphylococcus aureus. Essential oil was extracted by distillation using Stahl with water as the solvent and the yield of essential oil obtained was 0.22%. Determination of antibacterial activity and antibiofilm activity were carried out by microdilution method using microplate 96 U-PVC bottom wells against Staphylococcus aureus which is equivalent to the solution standard of ½ Mc Farland I. The results of antibacterial activity tests showed that MIC (Minimum Inhibitory Concentration) and MBC (Minimum Bactericidal Concentration) values were 0.05% (v/v) and 12.5% (v/v). Antibiofilm activity test showed that the essential oil of Cyperus rotundus L. tubers is able to inhibit 89.01% of the biofilm formation of Staphylococcus aureus on the concentration of 0.09% (v/v).
oai:ojs.jurnal.wima.ac.id:article/694
2015-06-19T09:14:35Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/694
2015-06-19T09:14:35Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 2, No 1 (2015)
Efek Antihiperurikemia Ekstrak Air Kelopak Bunga Rosela (Hibiscus sabdariffa L.) pada Tikus Putih Wistar Jantan
Wahyuningsih, Sri; Fakultas Farmasi UNJANI
Yulinah, Ellin; Sekolah Farmasi ITB
Sukrasno, .
N, Karina
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/694
en
Antihyperuricemia effectivity had been studying of water extract roselle calyx (Hibiscus sabdariffa L.) in Wistar
male rats used at 46.25 mg/kgBW, 92.5 mg/kgBW and 185 mg/kgBW by using uricostatic methods. In uricostatic
method had used drug comparison alopurinol 9 mg/kgBW of an induced with potassium oxonate 250 mg/kgBW
peritoneally and high purin diet which contained 10% seed of Gnetum gnemon administrations within 14
days. The test of uric acid content had observed on day 1, 7 and 14. The results showed in uricostatic method
with alopurinol as drug comparison that water extract of roselle calyx at doses 46,25 mg/kgBW and 185 mg/
kgBW had capability decreased the level of uric acid (p
oai:ojs.jurnal.wima.ac.id:article/699
2015-06-19T10:05:28Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/699
2015-06-19T10:05:28Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 2, No 1 (2015)
Formulasi and Evaluasi Stabilitas Fisik Suspensi Ubi Cilembu (Ipomea batatas L.) dengan Suspending Agent CMC Na dan PGS Sebagai Antihiperkolesterol
Fitriani, Yeyen Nor; Departemen Farmasi Industri, Fakultas Farmasi, Institut Ilmu Kesehatan Bhakti Wiyata Kediri
INHS, Cikra
Yuliati, Ninis
Aryantini, Dyah
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/699
en
Drug which has small solubility in water is one of the problems that cause instability of pharmaceutical
preparations. One drug practically insoluble in water is cilembu (Ipomoea batatas L.). So cilembu (Ipomoea
batatas L.) made in form of suspension in order to produce stable preparations in liquid form. Making of the
suspension cannot be separated from the suspending agent. CMC Na (Carboxymethylcellulose Sodium) and
PGS (pulvis gummosus) is suspending agent which have been studied to produce a stable suspension.
Accordingly, this study was conducted to know the suspension evaluation stability cilembu (Ipomoea batatas L.)
with a suspending agent CMC Na and PGS as antihypercholesterol. Method of manufacture is dispersion
method. Evaluation of physical stability test was conducted on the organoleptic, homogeneity, pH, density,
viscosity, sedimentation volume, and redispersion. Data were analyzed with repeated measures and shelflife.
Evaluation of physical stability the suspension cilembu with a suspending agent CMC Na and PGS on
observations organoleptic, homogeneity, density and redispersion showed no difference, while the pH,
viscosity and sedimentation volume were not significant differences (p< 0.05) during 30 days of storage.
oai:ojs.jurnal.wima.ac.id:article/4648
2023-08-06T16:20:07Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/4648
2023-08-06T16:20:07Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 10, No 1 (2023): February; 57-64
Penetapan Kadar Saponin dalam Gambas (Luffa acutangula L.) Hasil Pengeringan Matahari dan Pengeringan Oven Menggunakan Metode Gravimetri
http://journal.wima.ac.id/index.php/JFST/article/download/4648/13145
http://journal.wima.ac.id/index.php/JFST/article/download/4648/13146
Fitrianingsih, Natasya Hanindita; Sekolah Tinggi Imu Kesehatan Nasional
Lindawati, Novena Yety; Sekolah Tinggi Imu Kesehatan Nasional
2023-04-27 00:00:00
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/4648
gambas fruit (Luffa acutangula L.), saponins, sun drying, oven drying
en
Gambas fruit or oyong or often called ceme (Luffa acutangula L) or ridged gourd is a plant that belongs to the Cucurbitaceae family. Gambas fruit contains several important nutrients and also contains several chemical compounds, one of which is saponin which can be useful as an experctorant, antitussive, antidiabetic, anticholesterol, anticancer, antibacterial and antifungal. This research was conducted with the aim of knowing the differences in saponin levels and differences in yield in sun-dried and oven-dried squash fruits. Differences in temperature and drying method may allow for differences in the yield and saponin levels in the squash. Determination of saponin levels was carried out using the gravimetric method which was the advantage of not requiring a comparator (standard saponins). The result showed that the sun drying yield was 8,24% with ±SD 0,00021 and the oven drying yield was 7,21% with ±SD 0,02821 while the saponin content in sun drying was 0,39% with a coefficient of variation of 0,001% and oven drying saponin content of 11,96% with a coefficient of variation of 0,002%.
oai:ojs.jurnal.wima.ac.id:article/2233
2019-11-04T08:17:58Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/2233
2019-11-04T08:17:58Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 6, No 2 (2019); 66-73
Studi Penggunaan Sefalosporin Generasi Ketiga pada Pasien Pneumonia di Instalasi Rawat Inap Rumah Sakit Umum Haji Surabaya
Worotikan, Natania Imanuella; Fakultas Farmasi, Universitas Katolik Widya Mandala Surabaya,
Hasmono, Didik; Fakultas Farmasi, Universitas Airlangga Surabaya
Kasih, Elisabeth; Fakultas Farmasi, Universitas Katolik Widya Mandala Surabaya,
Ramdani, Dewi; Rumah Sakit Umum Haji, Surabaya
2019-10-31 22:14:29
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/2233
id
Pneumonia is an acute lung tissue infection caused by inflammation of the lung parenchyma and the presence of exudate compaction in lung tissue. Based on epidemiology, pneumonia can be differentiated into communityacquired pneumonia and health care-associated pneumonia. The HCAP category divided pneumonia into hospital acquired pneumonia and ventilator-associated pneumonia. This study aims to analyze the pattern of third generation cephalosporin use in pneumonia patients based on drug route of administration, dosage, frequency, interval and duration of drug usage, and laboratory data. This study was conducted retrospectively with time limited sampling method during the period of August 1, 2016 - August 31, 2017. The study was conducted in 31 patients with diagnosis of pneumonia undergoing hospitalization and received third generation cephalosporin antibiotic therapy at inpatient installation of RSU Haji Surabaya which traced through Medical Record. All samples were recorded on the data collection sheet, and then the data was recapitulated and analyzed. Based on the observation result, it was found that ceftriaxone with frequency and dose 2x1 g (iv) used as much as 41% (11 people), the combination between ceftriaxone 2x1 g (iv) with levofloxacin 1x1 g (iv) used as much as 22% (4 people). The longest use of third generation cephalosporin antibiotics was ceftriaxone (4-6 days) as much as 35%
(12 people).
oai:ojs.jurnal.wima.ac.id:article/715
2015-10-28T16:51:03Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/715
2015-10-28T16:51:03Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 2, No 2 (2015)
Pengaruh Pemberian Infus Kelopak Kering Rosella (Hibiscus sabdariffa) Terhadap Kadar Kolesterol Total Serum Darah Tikus Hiperkolesterolemia
Octavia, Stefani Kartika
Surdijati, Siti
Soegianto, Lisa
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/715
en
Rosella (Hibiscus sabdariffa) merupakan salah satu tanaman bermanfaat sebagai bahan makanan, minuman maupun bahan obat. Kelopak Rosella berkhasiat sebagai antihipertensi, antidiabetes, antikolesterol, terapi gangguan liver dan asam urat. Penelitian ini bertujuan untuk mengetahui apakah ada pengaruh yang signifikan dari pemberian infus kelopak kering Rosella dalam menurunkan kadar kolesterol total serum darah tikus hiperkolesterolemia. Penelitian ini menggunakan 25 tikus putih jantan galur Wistar yang diberi propiltiourasil 0,01% dan makanan tinggi kolesterol selama 2 minggu. Kemudian dibagi dalam lima kelompok, yaitu kontrol (PGA 3%), pembanding (Simvastatin 0,9 mg/kgBB) dan 3 kelompok uji yang diberi infus Rosella dosis 125 mg/kgBB, 250 mg/kgBB dan 500 mg/kgBB, secara oral selama 2 minggu. Data dianalisis dengan uji statistik Anova dilanjutkan uji Tukey HSD 5%. Perhitungan korelasi digunakan untuk mengetahui hubungan antara peningkatan dosis dengan penurunan kolesterol total. Tidak ada perbedaan bermakna pada setiap pasangan kelompok dengan signifikansi >0,05 untuk semua kelompok kecuali antara K1 dan K5 (signifikansi
oai:ojs.jurnal.wima.ac.id:article/4931
2024-01-29T05:16:57Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/4931
2024-01-29T05:16:57Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 10, No 2 (2023): October; 92-98
Uji Aktivitas Antikolesterol Ekstrak Kale (Brassica oleracea var. acephala DC)
Amalia, Angelina Divanny; Sekolah Tinggi Ilmu Kesehatan Nasional
Anggraini, Devina Ingrid; Sekolah Tinggi Ilmu Kesehatan Nasional
2023-10-25 00:00:00
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/4931
EC50; Ekstrak Kale; Lieberman Burchard; Penurunan Kolesterol
en
Kadar kolesterol dalam tubuh yang berlebih memiliki dampak yang buruk bagi kesehatan sehingga perlu dikontrol untuk menghindari resiko yang membahayakan tubuh. Alternatif pengobatan kolesterol selain dengan obat-obat sintetis dapat juga dengan memanfaatkan kandungan senyawa dalam tumbuhan seperti sayuran, buah, dan lain sebagainya. Kale (Brassica oleracea var. acephala DC) merupakan salah satu sayuran mengandung senyawa seperti flavonoid, tannin dan fenol yang dapat menurunkan kadar kolesterol dalam darah. Penelitian ini bertujuan untuk mengetahui aktivitas ekstrak kale dalam menurunkan kadar kolesterol. Analisis kualitatif ekstrak kale menunjukkan positif mengandung senyawa alkaloid, flavonoid, dan saponin. Analisis kuantitatif aktivitas antikolesterol dilakukan dengan menggunakan metode Lieberman-Burchard dengan seri konsentrasi ekstrak 15, 20, 25, 30, 35, dan 40 ppm. Hasil penelitian menunjukkan ekstrak kale memiliki aktivitas antikolesterol dengan nilai EC50 sebesar 32,350 ppm.
oai:ojs.jurnal.wima.ac.id:article/2240
2019-11-04T08:24:31Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/2240
2019-11-04T08:24:31Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 6, No 2 (2019); 103-108
Pengaruh Ekstrak Kulit Buah Mangga Harum Manis (Mangifera indica L) terhadap Tekanan Darah pada Tikus Putih Jantan Hipertensi
Ifmaily, Ifmaily; Sekolah Tinggi Farmasi Indonesia Yayasan Perintis Padang
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/2240
id
Hypertension is the most common disease in Indonesia. The impact of hypertension can affect other organs such as the kidneys, heart, and eventually cause death. The prevalence of hypertension increases from year to year. One alternative treatment for hypertension is the use of natural ingredients that contain flavonoids. Mango (the leaves, fruit, fruit peel and stems) is one of the plants that can be used for anti-hypertension, because of its flavonoid content. Ethanol extract of leaves, fruit and stem of Mango already proved as an antihypertensive drug, but the peel of the fruit has not been studied, so far it has only been a waste. The purpose of this study was to determine the effect of varying doses of the extract of mango peel varieties Harum Manis (EKBMHM) on white male hypertensive rats. This study was experimental with a pretest-posttest control group design, using male white rats, divided into 6 groups: negative control group, positive control, treatment group 30 mg / kg BW, treatment group 60 mg / kg BW, treatment group 120 mg / kg BW and comparison group (amlodipine 5 mg / kgBW. Prednisone 1.5 mg / kgBW in 2.5% NaCl are used to induce hypertension in animal. The parameters used were blood pressure which measured using a Non-Invasive Blood Pressure. Data analysis was calculated using one-way ANOVA followed by Duncan's test. The results obtained showed a dose of 30 mg / kg BW and a dose of 120 mg / kg BW extract of mango peel cannot reduce blood pressure, while a dose of 60 mg / kg BW can reduce blood pressure in hypertensive rats where the results of blood pressure measurements are not significantly different with comparison group (amlodipine 5 mg / kg BW). The conclusion for this research,the administration of mango peel varieties Harum Manis extract at a dose of 60 mg / kg BW given to hypertensive rats shows potential as an antihypertensive drug (p value = 0.047).
oai:ojs.jurnal.wima.ac.id:article/720
2015-10-28T16:51:04Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/720
2015-10-28T16:51:04Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 2, No 2 (2015)
Pembentukan Kokristal Katekin dengan Nikotinamida
Bakhtiar, Amri
Gaesari, Sherly Rahmah
Zaini, Erizal
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/720
en
Telah dilakukan pembuatan kokristal katekin-nikotinamida dan evaluasi kelarutannya dalam pelarut air. Kokristal dibuat dengan dua metode, yaitu rekristalisasi dengan penguapan pelarut etanol 96% menggunakan rotary evaporator (metode I) dan penguapan pelarut pada suhu ruang (metode II). Karakterisasi kokristal katekin-nikotinamida dilakukan dengan difraksi sinar-X, analisis termal DTA (Differential Thermal Analysis), FT IR (Fourier Transform Infra Red), dan SEM (Scanning Electron Microscopy), serta uji kelarutan dalam pelarut air menggunakan orbital shaker selama 24 jam. Penetapan kadar katekin dilakukan dengan metode KCKT (Kromatografi Cair Kinerja Tinggi) menggunakan fase gerak air-asetonitril-metanol-etil asetat-asam asetat glasial (89:6:1:3:1). Hasil difraktogram sinar-X pada kokristal metode I menunjukkan terbentuknya padatan amorf, sedangkan pada metode II menunjukkan terbentuknya fase kristalin baru (kokristal). Pada analisis termal menggunakan DTA terjadi perubahan titik lebur pada kokristal metode I maupun metode II yang berbeda dengan titik lebur katekin dan nikotinamida yang menunjukkan terbentuknya campuran eutektik. Pada analisis FT IR, baik kokristal metode I maupun metode II terjadi pergeseran bilangan gelombang dari spektrum katekin dan nikotinamida yang menunjukkan terbentuknya ikatan hidrogen antara gugus hidroksi fenol dari katekin dengan gugus amida dari nikotinamida. Dari hasil SEM, terlihat habit kristal dari kokristal metode I maupun metode II berbeda dibandingkan dengan habit kristal katekin maupun nikotinamida yang menunjukkan terbentuknya kokristal. Namun kelarutan kokristal katekin-nikotinamida metode I (132,17 mg/100 mL) maupun metode II (131,09 mg/100 mL) tidak berbeda nyata dengan
kelarutan katekin (124,58 mg/100 mL).
Kata kunci: kokristal, katekin, nikotinamida, kelarutan, KCKT.
oai:ojs.jurnal.wima.ac.id:article/2345
2020-02-05T14:35:47Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/2345
2020-02-05T14:35:47Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 1, No 1 (2013); 25-30
Optimasi Formula Tablet Floating Metformin Hidroklorida Menggunakan Polimer Guar Gum
Elim, Siska; Faculty of Pharmacy, Widya Mandala Catholic University Surabaya
Hadisoewignyo, Lannie; Faculty of Pharmacy, Widya Mandala Catholic University Surabaya
Sukarti, Emi; Faculty of Pharmacy, Widya Mandala Catholic University Surabaya
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/2345
id
Metformln hydrochloride Is an orally administered blguanlde derivative drug and functions as an anti hyperglycemic In patient with type 2 diabetes mellitus with bioavallablllty between 50-6096. Floating system Is the one method to enhance absorption and bioavallablllty of metformln hydrochloride. The purpose of this research was to determine the effect of guar gum concentration and concentration effervescent components and Interactions of both components on physical properties of tablets, floating lag time, floating time, and dissolution rate constant and get the optimum formula with drug release pattern according to zero order kinetics. In this research using factorial design with two factors Is concentrations factor of guar gum at 15-2096 and concentrations factor of effervescent components Is citric acid and sodium bicarbonate (1:1) at 5-1096. The method used Is direct compression method. Concentration of guar gum have a significant effect on floating lag time and dissolution rate constant but do not have a significant effect on tablet hardness. While the concentration of effervescent components not have a significant effect on tablet hardness and dissolution rate constant but a significant effect on floating lag time. Interaction between guar gum concentration and concentration effervescent components not have a significant effect on tablet hardness, floating lag time, and dissolution rate constant Based on Design - Expert program optimization, the optimum formula obtained Is formula with combination 19,596 guar gum concentration and 5,596 concentration effervescent
components which resulting 11,43 Kp hardness, floating lag time 8,69 min and K dissolution 0,324 mUmln.
oai:ojs.jurnal.wima.ac.id:article/725
2015-10-28T16:51:04Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/725
2015-10-28T16:51:04Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 2, No 2 (2015)
Fraksinasi dan Identifikasi Senyawa Antioksidan pada Ekstrak Etanol Daun Sirsak (Annona muricata L.) secara Kromatografi Kolom
Sari, Diyan Maya
Wijaya, Sumi
Setiawan, Henry Kurnia
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/725
en
Annona muricata L. merupakan salah satu tanaman dari familia Annonaceae yang mengandung antioksidan alami yang dapat digunakan untuk pengobatan berbagai jenis penyakit. Berdasarkan kemampuannya yang memiliki daya antioksidan tersebut, maka dilakukan pemisahan senyawa antioksidan dan uji untuk mem-bandingkan aktivitas daya antioksidan dari ekstrak etanol dengan fraksinya. Pemisahan senyawa antioksidan dengan menggunakan kromatografi kolom dan pengujian aktivitas antioksidan dengan metode DPPH (1,1-diphenyl-2-picrylhidrazyl). Berdasarkan hasil data KLT, spektrum UV-Vis dan spektroskopi IR dapat disimpul-kan bahwa senywa antioksidan mengandung flavonoid. Hasil pengujian aktivitas antioksidan menunjukkan bahwa ekstrak etanol daun sirsak memiliki aktivitas antioksidan dengan nilai 0,25 ± 0,037 mg/mL, sedang-kan hasil dari fraksi menunjukkan bahwa aktivitas antioksidannya lebih besar dengan nilai 0,14 ± 0,011 mg/mL. Golongan metabolit sekunder dalam fraksi etanol daun sirsak yang dapat berfungsi sebagai senyawa antioksidan adalah flavonoid dan fraksi etanol tersebut memiliki aktivitas antioksidan yang lebih besar di-bandingkan dengan aktivitas antioksidan ekstrak etanol.
Kata kunci: Annona muricata L., antioksidan, kromatografi kolom, DPPH.
oai:ojs.jurnal.wima.ac.id:article/2392
2022-09-24T02:32:37Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/2392
2022-09-24T02:32:37Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 7, No 1 (2020): Februari; 20-26
Studi Penggunaan Kombinasi Obat Fenitoin dan Natrium Valproat terhadap Serum Magnesium dan Jumlah Kejang pada Pasien Epilepsi di RSUD DR. Soetomo
Sambono, Vonneth Glorya; Fakultas Farmasi, Universitas Katolik Widya Mandala Surabaya
Sugianto, Paulus; Departemen Neurologi, Rumah Sakit Umum Daerah Dr. Soetomo, Surabaya
Kasih, Elisabeth; Fakultas Kedokteran, Universitas Airlangga, Surabaya
Octavia, Evi; Instalasi Farmasi, Rumah Sakit Umum Daerah Dr. Soetomo, Surabaya
2020-03-10 00:00:00
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/2392
id
Epilepsy is a clinical condition that is recognized by the pattern of seizures ranging from neurological development status according to age, history of seizures, and prognosis. Clinical research in humans and animals shows that magnesium deficiency can cause seizures. Drug therapy in epilepsy patients can be done by monotherapy and polytherapy. The combination of phenytoin and sodium valproate can be used as a polytherapy. The purpose of this study was to describe the serum magnesium levels and the number of seizures in epilepsy patients who received phenytoin and sodium valproate using a descriptive method prospectively. The parameters used are the conditions of the patient while receiving treatment. Ten epilepsy patients which treated with combination therapy of phenytoin and sodium valproate were used for this research.The results showed that the highest dose used in polytherapy was phenytoin 500 mg and sodium valproate 500 mg 2 x 1 po. The highest normal magnesium level was 2.21 mg / dL (10%). The highest number of seizures was 7 times a month (10%) and no adverse drug interactions occured. Phenytoin and sodium valproate therapy can minimize the number of seizures but do not affect the patient's magnesium level.
oai:ojs.jurnal.wima.ac.id:article/2676
2020-10-31T22:36:08Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/2676
2020-10-31T22:36:08Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 7, No 2 (2020): Oktober; 64-69
Sintesis O-(Isoleusil) Parasetamol dan Uji Aktivitas Analgesik terhadap Mencit (Mus musculus) dengan Metode Hot Plate
Parwitha, Ida Ayu Andri; Fakultas Farmasi, Universitas Katolik Widya Mandala Surabaya, Surabaya
Siswodihardjo, Siswandono; Fakultas Farmasi, Universitas Airlangga, Surabaya
2020-10-30 00:00:00
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/2676
O-(isoleusil)parasetamol; analgesik; tionil klorida; parasetamol
in
Parasetamol merupakan obat analgesik lini pertama yang digunakan dalam tata laksana nyeri. Penggunaan obat tersebut dalam jangka waktu panjang dengan dosis besar berpotensi memunculkan efek samping hepatotoksik. Guna meminimalkan efek samping dan meningkatkan aktivitas analgesik dari Parasetamol maka dilakukan modifikasi struktur –OH pada gugus parasetamol. Tujuan dari penelitian ini adalah mensintesis senyawa O-(isoleusil)parasetamol melalui reaksi Schotten Baumann antara Parasetamol dan Isoleusil klorida. Senyawa sintesis tersebut diuji aktivitas analgesiknya pada Mencit. Pemurnian senyawa hasil sintesis melalui proses rekristalisasi menggunakan campuran pelarut etanol:air (1:2) dan diperoleh senyawa berbentuk serbuk berbau menyengat dengan rendemen hasil 32%. Setelah senyawa terbukti murni maka dilanjutkan dengan identifikasi struktur senyawa menggunakan spektrofotometer inframerah dan spektrometer 1H-NMR. Hasil uji menunjukkan bahwa senyawa hasil síntesis sesuai yang diharapkan. Pengujian aktivitas analgesik senyawa dilaksanakan pada Mencit (Mus musculus) dengan metode hot plate. Dosis yang digunakan dalam penelitian ini adalah 12,5; 25; 50; 100; 200 mg/kg BB diberikan secara intraperitoneal dan parasetamol dengan dosis sama sebagai senyawa pembanding. Hasil penelitian menunjukkan nilai ED50 O-(isoleusil) parasetamol 50 mg/kg BB dan ED50 parasetamol adalah 66 mg/kg BB. Berdasarkan nilai ED50 dapat disimpulkan bahwa O-(isoleusil)parasetamol memiliki aktivitas analgesik yang lebih tinggi dibanding parasetamol. Hasil uji statistik Tukey HSD menunjukkan bahwa aktivitas analgesik parasetamol dan O-(isoleusil)parasetamol tidak berbeda bermakna.
oai:ojs.jurnal.wima.ac.id:article/812
2016-06-08T14:50:07Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/812
2016-06-08T14:50:07Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 2, No 1 (2015)
Uji Aktivitas Antidiabetes Ekstrak Air Kelopak Bunga Rosella (Hibiscus sabdariffa L.) pada Tikus dengan Metode Induksi Aloksan
Dianasari, Dewi
Fajrin, Fifteen Aprila
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/812
en
Salah satu jenis tanaman yang diduga memiliki khasiat sebagai antidiabetes adalah Rosella (Hibiscus sabdariffa
L.) yang termasuk dalam famili Malvaceae. Kelopak bunga Rosella (Hibiscus sabdariffa L.) mengandung senyawa
flavonoid khususnya antosianin dan vitamin C sebagai antioksidan yang mampu menetralisir radikal bebas yang
menjadi salah satu penyebab diabetes dan mengurangi komplikasi penyakit tersebut. Tujuan dari penelitian ini
adalah untuk menguji aktivitas antidiabetes dari ekstrak air kelopak bunga Rosella (Hibiscus sabdariffa L.) dan
untuk mengetahui aktivitas antidiabetes pada ekstrak air kelopak bunga Rosella (Hibiscus sabdariffa L.) pada
dosis yang berbeda (250 mg/kgBB, 500 mg/kgBB, dan 750 mg/kgBB). Metode penelitian yang digunakan
adalah dengan cara induksi aloksan. Hasil penelitian menunjukkan bahwa kelompok uji ekstrak air kelopak bunga
Rosella (Hibiscus sabdariffa L.) dosis 500 mg/kgBB dan 750 mg/kgBB memiliki aktivitas antidiabetes yang
sebanding dengan kontrol positif yaitu Glibenklamid dengan dosis 0,45 mg/kgBB, sedangkan kelompok uji
ekstrak air kelopak bunga Rosella (Hibiscus sabdariffa L.) dosis 250 mg/kgBB tidak menunjukkan aktivitas
antidiabetes yang berarti karena tidak ada perbedaan yang bermakna dengan kontrol negatif (aquadest 5 mL/kgBB).
oai:ojs.jurnal.wima.ac.id:article/2793
2020-10-31T22:36:09Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/2793
2020-10-31T22:36:09Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 7, No 2 (2020): Oktober; 81-85
Analisa Pengendalian Persediaan Dengan Metode EOQ, JIT dan MMSL DiInstalasi Farmasi Rumah Sakit XXX Kota Mojokerto
Doso, Tri; Universitas Setia Budi Surakarta
Sunarni, Titik; Universitas Setia Budi Surakarta
Herdwiani, Wiwin; Universitas Setia Budi Surakarta
2020-10-30 00:00:00
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/2793
Analisa; EOQ, JIT; MMSL; Indikator Efisien
in
Pengendalian persediaan (managemen inventory) obat sangat penting karena persediaan obat merupakan permasalahan yang sangat krusial dalam manajemen operasional rumah sakit. Hal ini dikarenakan pengendalian persediaan obat yang tepat dapat berdampak yang kuat terhadap perolehan kembali atas investasi agar dapat melayani pasien dengan baik. Maka persediaan perlu dikelola dengan metode diantaranya Economic Order Quantity (EOQ), Just In Time ( JIT), dan Minimum Maximum Stock Level (MMSL). Tujuan penelitian ini adalah mengetahui pengendalian persediaan obat di Instalasi Farmasi Rumah Sakit XXX Kota Mojokerto serta pengaruh metode EOQ, JIT, dan MMSL terhadap nilai persediaan dan Inventory Turn Over Ratio (ITOR).Rancangan penelitian ini dilakukan secara deskriptif non eksperimental dengan pengambilan data secara retrospektif di Instalasi Farmasi Rumah Sakit XXX tahun 2016-2018. Analisa hasil dengan melakukan pengelompokan persediaan berdasarkan kategori ABC yang selanjutnya diterapkan metode EOQ, JIT, dan MMSL kemudian dibandingan nilai persediaan dan ITOR antara nilai riil dengan nilai perhitungan.Berdasarkan hasil penelitian diperoleh rata-rata nilai persediaan pada tahun 2016-2018 diperoleh nilai persediaan paling efisien dengan selisih paling besar bila dibandingkan dengan nilai persediaan riil yaitu pada metode EOQ dengan nilai persediaan Rp 15.262.175.782,00. Sedangkan pada perhitungan ITOR diperoleh nilai 28,26 kali. Hal ini berarti bahwa pengendalian persediaan pada Instalasi Farmasi Rumah Sakit XXX sudah efisien. Kesimpulan dari penelitian ini adalah pengendalian persediaan obat dan alat kesehatan di Instalasi Farmasi Rumah Sakit XXX Kota Mojokerto sudah efisien bila dibandingkan dengan menggunakan metode EOQ.
oai:ojs.jurnal.wima.ac.id:article/2009
2019-10-14T10:40:55Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/2009
2019-10-14T10:40:55Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 6, No 1 (2019); 26-33
Analisis Efektivitas Pengikat Fosfat Tablet Kalsium Karbonat yang Dikunyah Dibandingkan yang Ditelan Utuh pada Pasien Penyakit Ginjal Kronis Dengan atau Tanpa Gangguan Saluran Cerna
Prawesti, Galuh Nawang; Fakultas Farmasi Universitas Katolik Widya Mandala Surabaya
Yogiantoro, R. Moh.; Fakultas Kedokteran Universitas Airlangga, Surabaya
Widodo, Gunawan; Fakultas Kedokteran Universitas Airlangga, Surabaya dan Spesialis Ilmu Penyakit Dalam di RSU Haji, Surabaya
Purnamayanti, Anita; Fakultas Farmasi Universitas Surabaya
2019-04-23 14:17:18
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/2009
id
Chronic Kidney Disease (CKD) patient with Mineral and Bone Disorder complication have to chew calcium carbonate tablet as a phosphate binder, but infact, patient swallow it in a whole. Gastrointestinal (GI) disorders can affect the efficacy of medicine. This study aims to analyze the effectiveness comparation of chewed and whole swallowed calcium carbonate tablet in CKD patients with or without gastrointestinal disorders. This prospective quasi experimental study with non-inferiority design was conducted on May 28th to August 22nd 2012, with 22 sample (stage 3-5 CKD), 14 men, 8 women, divided into 4 groups (1st: patients with GI disorder and whole swallowed calcium carbonate, 2nd: with GI disorders and chewed tablet, 3rd: without GI disorders and whole swallowed tablet, 4th group: without GI disorders and chewed tablet, all tablet are used with meal). Before and after the 6th week research period, calcium and phosphate blood levels measurements had been taken, adherence had been measured every two weeks using the Morisky questionnaire and pill count. The results showed that there was no significant difference in the increased of calcium levels, except for group 1 compared to group 3 (p = 0.027), the decreased phosphate levels (p = 0.724; 0.089; 0.089; 0.414; 0.569; 1.000) and the value of the product calcium-phosphate (p = 1.000; 0.308; 0.186; 0.414; 0.425; 0.728). The conclusion is that the way to use the medicine and the states of gastrointestinal disorders did not significantly influence the effectiveness of calcium carbonate tablet.
oai:ojs.jurnal.wima.ac.id:article/3086
2022-09-24T02:31:56Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/3086
2022-09-24T02:31:56Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 8, No 1 (2021): Februari; 1-7
Uji Aktivitas Antibakteri Hasil Fermentasi Kulit Buah Naga Merah (Hylocereus polyrhizus) terhadap Propionibacterium acnes
Agustina, Merry; Universitas Katolik Widya Mandala Surabaya, Indonesia
Soegianto, Lisa; Universitas Katolik Widya Mandala Surabaya, Indonesia
Sinansari, Restry; Universitas Katolik Widya Mandala Surabaya, Indonesia
2021-03-21 11:41:12
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/3086
antibakteri, Propionibacterium acnes; kulit buah naga merah; fermentasi; difusi cakram
id
Bakteri yang berperan dalam tumbuhnya jerawat diantaranya adalah Propionibacterium acnes dan Staphylococcus epedermidis. Pengobatan jerawat menggunakan antibiotik dalam jangka panjang dapat menimbulkan resistensi terhadap antibiotik. Kulit buah naga merah (Hylocereus polyrhizus) dapat digunakan sebagai alternatif antibakteri. Penelitian ini bertujuan untuk mengetahui golongan senyawa yang terkandung pada hasil fermentasi kulit buah naga merah dan aktivitas antibakteri terhadap Propionibacterium acnes. Pada penelitian ini kulit buah naga merah difermentasi selama 12 hari pada suhu kamar, hasil fermentasi diuji golongan senyawa dengan cara kromatografi lapis tipis dan uji aktivitas antibakteri dengan metode difusi cakram dengan parameter daerah hambat pertumbuhan (DHP). Hasil yang diperoleh uji aktivitas antibakteri hasil fermentasi kulit buah naga merah dengan konsentrasi 10%, 20%, 40%, 60%, 80% dan 100% tidak menunjukkan adanya hambat pertumbuhan terhadap bakteri Propionibacterium acnes. Hasil skrining golongan senyawa hasil fermentasi kulit buah naga merah memiliki kandungan flavonoid.
oai:ojs.jurnal.wima.ac.id:article/2048
2019-05-23T12:42:36Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/2048
2019-05-23T12:42:36Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 5, No 1 (2018); 1-5
Formulasi Sediaan Eyeshadow Ekstrak Air Buah Syzygium cumini dalam Bentuk Compact Powder
Dwiwulandari, Fransisca Yunita; Fakultas Farmasi, Universitas Katolik Widya Mandala Surabaya
Darsono, Farida Lanawati; Fakultas Farmasi, Universitas Katolik Widya Mandala Surabaya
Wijaya, Sumi; Fakultas Farmasi, Universitas Katolik Widya Mandala Surabaya
2018-05-23 00:00:00
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/2048
id
Coloring substance are needed in eyeshadow. It is used to give colors, shadows, and glittery effect on eyes. The trend in beauty world nowadays is using a natural dye because of safety issues. Antocyanine, which is contained in “juwet” fruit (Syzygium cumini), is one of the potential natural dyes. The aim of this research is to know the effect of Syzygium cumini in different concentration (20%, 25% dan 30%) on the physical quality and ffectiveness of the eyeshadow. The extract of Syzygium cumini fruit was formulated into compact powder eyeshadow. This type of preparation is the dominant dosage form used because it has good adhesiveness to the skin. The extract was obtained by extracting the juice and evaporated it using thermostatic water bath in the temperature of 40-60°C. The result showed that the increase in extract concentration significantly affected the physical quality test results (organoleptic, pH, particle size, friability and hardness), but did not affect the color dispersion and effectiveness. Based on the evaluation, formula II (extract of Syzyium cumini 25 %) was chosen as the best formula.
oai:ojs.jurnal.wima.ac.id:article/2761
2021-11-26T14:50:54Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/2761
2021-11-26T14:50:54Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 8, No 2 (2021): Oktober; 62-68
Sintesis dan Uji Aktivitas Antioksidan Senyawa 4,4’-dinitrodibenzalaseton dengan Metode DPPH
Jessica, Jessica; Faculty of Pharmacy, Widya Mandala Surabaya Catholic University
Budiati, Tutuk; Fakultas Farmasi, Universitas Katolik Widya Mandala Surabaya
Caroline, Catherine; Fakultas Farmasi, Universitas Katolik Widya Mandala Surabaya
2021-11-26 15:50:49
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/2761
synthesis, Claisen-Schmidt condensation, 4,4’-dinitrodibenzalacetone, antioxidant, DPPH
en
Senyawa dibenzalaseton dan turunannya yaitu senyawa 4,4’-dinitrodibenzalaseton adalah salah satu jenis antioksidan sintetik dan tergolong ke dalam analog Kurkumin. Senyawa Dibenzalaseton dan 4,4’-dinitrodibenzalaseton merupakan senyawa yang dapat menangkal radikal bebas yang disintesis melalui reaksi kondensasi Claisen-Schmidt dengan perbandingan Benzaldehida/4-nitrobenzaldehida dan Aseton adalah 2:1 mEq dengan menggunakan katalis NaOH. Hasil sintesis dilakukan uji kemurnian dan uji identifikasi struktur dengan menggunakan spektroskopi Inframerah. Persentase rendemen hasil sintesis dibenzalaseton dan 4,4’-dinitrodibenzalaseton adalah sebesar 92,30% dan 96,70%. Uji aktivitas antioksidan dilakukan dengan metode DPPH, dengan senyawa Kurkumin dan Vitamin C sebagai pembanding dan hasilnya dinyatakan dengan nilai IC50. Perolehan rata-rata nilai IC50 dari senyawa dibenzalaseton, 4,4’-dinitrodibenzalaseton, kurkumin dan vitamin C secara berturut-turut adalah 66 mM, 1,6 mM, 0,074 mM, dan 0,0846 mM. Hal ini menunjukkan bahwa aktivitas antioksidan senyawa 4,4’-dinitrodibenzalaseton lebih besar dibanding dengan senyawa dibenzalaseton. Nilai IC50 yang rendah dari senyawa kurkumin menunjukkan bahwa aktivitas antioksidan yang dimiliki oleh Kurkumin lebih tinggi dari senyawa hasil sintesis. Potensi antioksidan yang dihasilkan oleh dan 4,4’-dinitrodibenzalaseton terhadap vitamin C adalah sebesar 5,28%.
oai:ojs.jurnal.wima.ac.id:article/2053
2019-05-23T12:42:39Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/2053
2019-05-23T12:42:39Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 5, No 1 (2018); 30-37
Profil Penggunaan Insulin Pada Pasien Diabetes Melitus Tipe 2 Dengan Ulkus/ Gangren Di Rumah Sakit Umum Daerah (RSUD) Kabupaten Sidoarjo
Hariyati, Fera; Fakultas Farmasi Universitas Katolik Widya Mandala Surabaya
Hasmono, Didik; Fakultas Farmasi Universitas Katolik Widya Mandala Surabaya
Kasih, Elisabeth; Fakultas Farmasi Universitas Katolik Widya Mandala Surabaya
2018-05-23 00:00:00
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/2053
id
Diabetis mellitus is still a health problem in the world. It is a condition of hyperglycemia which is at risk of causing macrovascular and microvaskular complications. The prevalence of diabetes mellitus continues to increase
throughout the world, including in Indonesia. One of diabetes complications is diabetic ulcer or gangrene. Diabetic ulcer or gangrene is common complication of diabetes mellitus wich can be caused by uncontrolled blood glucose levels. The aim of this study was to find the profile of insulin use in patiens with type 2 diabetes mellitus with ulcer
or gangren in RSUD Kabupaten Sidoarjo. It was an observational-descriptive study. Data were collected retrospective using purposive sampling method in the period of January 2017 to December 2017 at RSUD Kabupaten Sidoarjo. The results of observational study on 19 patients showed the insulin therapy used in this study, where 42% of patients used single insulin therapy and 58% of patiens used combination insulin therapy. In this study the commonly used single insulin was rapid acting insulin (Novorapid®) 42%, whereas the combination insulin used was rapid acting insulin with long acting insulin (Novorapid®-Lantus®) 58%. Based on glycemic
target, patients with blood glucose levels reached the glycemic target were 10% of patients, the ones that not reached the glycemic target were 80% of patients and the ones that reached hypoglicemia were 10% of patients.
In this study, the severity category of diabetes mellitus patients with ulcers/ gangrene was gangrene 58%, ulcers 26%, cellulitis 11% and sepsis 5%.
oai:ojs.jurnal.wima.ac.id:article/3323
2023-04-12T02:22:57Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/3323
2023-04-12T02:22:57Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 9, No 1 (2022): Februari; 1-6
Analisis Akar Penyebab Masalah dalam Meningkatkan Overall Equipment Effectiveness (OEE) Mesin Pengisi Bedak ke Kaleng PT. CORONET CROWN
Irawan, Yanuar Hadi; Universitas Surabaya
Wijaya, Sagitha Devina; Universitas Surabaya
2022-08-30 06:57:38
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/3323
OEE; Herocyn; mesin pengisi bedak; diagram pareto; diagram sebab-akibat
ind
Industri farmasi, seperti PT.CORONET CROWN memperoleh tantangan dalam menghadapi masa pandemi covid-19 dimana produktivitas dan efisiensi mesin harus berjalan dengan baik untuk menghasilkan produk yang berkualitas, bermutu baik, dan kapasitas produksi yang maksimal dengan harga yang kompetitif. Bedak Herocyn® merupakan salah satu produk andalan PT.CORONET CROWN dimana mengalami peningkatan permintaan pasar setiap tahunnya. Penelitian ini bertujuan untuk menghitung produktivitas dan efisiensi mesin pengisi bedak Herocyn® ke kaleng sehingga dapat mengidentifikasi permasalahan pada mesin dan menyelesaikannya dengan solusi yang tepat agar produktivitas bedak meningkat. Metode yang digunakan adalah dengan perhitungan overall equipment effectiveness (OEE) pada dua mesin pengisi bedak selama bulan januari-desember 2020 dengan mendapatkan data loading time, downtime, total product, ideal cycle time, operating time dan total defect. Hasil OEE digunakan untuk mengidentifikasi six big losses kemudian permasalahan diidentifikasi menggunakan diagram pareto dan diagram sebab akibat sehingga solusi yang tepat dapat ditentukan. Hasil penelitian, nilai OEE mesin filling powder I dan II berturut-turut adalah 75,5% dan 78,3%. Nilai OEE kedua mesin masih dibawah nilai ideal. Berdasarkan hasil diagram pareto, kontribusi tertinggi tidak idealnya nilai OEE kedua mesin yaitu idling and minor stoppages losses, setelah dianalisa menggunakan diagram sebab akibat akar masalahnya adalah ketidakseragamnya ketrampilan operator dan preventive maintenance kurang optimal.
oai:ojs.jurnal.wima.ac.id:article/2138
2019-09-13T14:01:12Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/2138
2019-09-13T14:01:12Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 5, No 2 (2018); 64-69
Formulasi Sediaan Masker Wajah Ekstrak Labu Kuning (Cucurbita moschata) Bentuk Clay Menggunakan Bentonit dan Kaolin Sebagai Clay Mineral
Santoso, Cynthia C.; Fakultas Farmasi, Universitas Katolik Widya Mandala Surabaya
Darsono, Farida L.; Fakultas Farmasi, Universitas Katolik Widya Mandala Surabaya
Hermanu, Liliek S.; Fakultas Farmasi, Universitas Katolik Widya Mandala Surabaya
2019-09-13 16:01:02
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/2138
id
Free radicals can cause oxidative damage that plays a role in the aging process and cause degenerative diseases that appear on the skin, so that antioxidants are needed to reduce the cumulative effects of oxidative damage in the form of clay mask. One of the natural materials that can be used as a clay mask is pumpkin fruit. Beta carotene in the yellow pumpkin can be used as an antioxidant that has a mechanism of electron transfer process so that free radical can be deactivated, and the saponin content in yellow pumpkin was function as cleanser effect. The aims of this study were to determine the effect of the combination of bentonite and kaolin as clay
minerals, and to get the optimum composition of the formula. Clay mask formulation was optimized using factorial design with design expert software ver 10.0. Responses used were the viscosity, spreadability, and drying time. The results showed that bentonite give a significant effect to increase the viscosity, decrease spreadability and drying time. Kaolin gives a significant effect to increase the viscosity, decrease spreadability and drying time. The interaction between kaolin and bentonite give significant effect to increase the viscosity, spreadability, and drying time. The optimum formulation of clay mask was obtained with the combination of bentonite 23.95% and kaolin 18.60%, which estimates viscosity 236222 cps; spreadability 4.20 cm; and drying time 14.65 minute.
oai:ojs.jurnal.wima.ac.id:article/2143
2019-09-13T14:01:12Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/2143
2019-09-13T14:01:12Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 5, No 2 (2018); 100-111
Studi pendahuluan: Korelasi Aktivitas Antikolesterol dengan Aktivitas Antioksidan Ekstrak Etanol Daun Salam (Syzygium polyanthum)
Wijaya, Sumi; Fakultas Farmasi Universitas Katolik Widya Mandala Surabaya
Yonas, Stefani Maureen Kasih; Fakultas Farmasi Universitas Katolik Widya Mandala Surabaya
Hartanti, Lanny; Fakultas Farmasi Universitas Katolik Widya Mandala Surabaya
Setiawan, Henry K.; Fakultas Farmasi Universitas Katolik Widya Mandala Surabaya
Soegianto, Lisa; Fakultas Farmasi Universitas Katolik Widya Mandala Surabaya
2019-09-13 16:01:08
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/2143
id
Bay leaf leaves (Syzygium polyanthum) are known to have anti-cholesterol activity, with the mechanism inhibited HMG-CoA Reductase enzyme. The purpose of this study was to determine the correlation between anticholesterol activity of bay leaf ethanol extract obtained by percolation method and its antioxidant activity. The parameter used to measure anticolesterol activity is the IC50 value. Antioxidant activity was evaluated by DPPH and Frap methods. The results showed that the ethanolic extract of bay leaves had an IC50 value of 49.50 ± 0.70 ppm. Ethanol extract of bay leaf showed antioxidant activity with IC50 value of 888.0835 ppm and equality of values with 1 mM FeSO4 of 295 ppm. Based on the results of the analysis, the anticholesterol activity of Bay leaf ethanol extract in inhibiting the HMG-CoA Reductase enzyme did not have a linear correlation with its antioxidant activity.
oai:ojs.jurnal.wima.ac.id:article/3258
2023-04-12T02:22:58Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/3258
2023-04-12T02:22:58Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 9, No 1 (2022): Februari; 35-41
Pengaruh Pemberian Ekstrak Etanol Daun Banto (Leersia hexandra Sw.) terhadap Aktivitas Antiinflamasi pada Tikus Putih Jantan yang Diinduksi Karagena
http://journal.wima.ac.id/index.php/JFST/article/download/3258/8325
Rizal, Rosiana; Universitas Dharma Andalas, Padang
Afriyeni, Helmice; Universitas Dharma Andalas, Padang
Tari, Mei Nissar Yulas; Universitas Dharma Andalas, Padang
2022-03-30 00:00:00
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/3258
Estrak etanol daun banto, Leersia hexandra Sw., inflamasi, inhibisi radang
en
Penelitian ini dilakukan untuk mengetahui pengaruh pemberian ekstrak etanol daun banto (Leersia hexandra Sw.) terhadap aktivitas antiinflamasi pada tikus putih jantan yang diinduksi karagenan. Metode pembuatan ekstrak dengan maserasi menggunakan pelarut etanol 70%. Uji aktivitas antiinflamasi yang dilakukan menggunakan hewan uji tikus putih jantan sebanyak 15 ekor dan dibagi menjadi 5 kelompok. Kelompok 1 (Kontrol positif) diberikan suspensi Na-CMC 0,5%, kelompok 2 (pembanding) diberikan natrium diklofenak, sedangkan kelompok 3, 4, dan 5 secara berturut-turut diberikan ekstrak etanol daun banto sebesar 50, 100, 200 mg/kgBB. Setelah 30 menit telapak kaki tikus diinduksi dengan karagenan.Volume radang diukur dengan menggunakan alat plestismometer yang dilakukan selama 5 jam. Data dianalisis secara statistik menggunakan Anova (Analysis of variance) dua arah dan dilajutkan dengan Duncan. Hasil penelitian menunjukkan efek ekstrak etanol daun banto memiliki efektivitas volume radang. Dosis dan waktu berpengaruh signifikan (P<0,05) terhadap persentase volume radang. Sedangkan interaksi dosis dan waktu tidak berpengaruh signifikan (P>0,05) dengan persentase volume radang. Ekstrak etanol daun banto dapat menurunkan volume radang pada telapak kaki tikus dan efek penurunan radang ditunjukkan pada dosis 100 mg/kgBB (0,21%).
oai:ojs.jurnal.wima.ac.id:article/2174
2019-10-14T10:20:12Z
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http://journal.wima.ac.id/index.php/JFST/article/view/2174
2019-10-14T10:20:12Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 4, No 1 (2017); 18-24
Uji Aktivitas Inhibitor Xanthin Oksidase dari Fraksi Ekstrak Etanol Herba Peperomia pellucida
Prihastuti, Angelina Ajeng; Fakultas Farmasi, Universitas Katolik Widya Mandala Surabaya
Wijaya, Sumi; Fakultas Farmasi, Universitas Katolik Widya Mandala Surabaya
Hartanti, Lanny; Fakultas Farmasi, Universitas Katolik Widya Mandala Surabaya
2019-10-14 12:20:06
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/2174
Peperomia pellucida (L.) Kunth known as Suruhan is a potential medicinal plants, used traditionally to treat gout. Suruhan herb (Peperomia pellucida (L.) Kunth) had been studied in vivo, and found to be able to lowering uric acid levels in the blood. Ethanol extract of Peperomia pellucida (L.) Kunth herb also had been studied in vitro, and found to be potential to inhibit xanthine oxidase. The purpose of this study is to know the potential of fraction from ethanol extract of Peperomia pellucida (L.) Kunth. herb as xanthine oxidase inhibitor compared to allopurinol and its ethanolic extract. Ethanol extract of Peperomia pellucida (L.) Kunth herb was obtained by percolation method using ethanol 96%. The fractionation is done by column chromatography method using silica as stationary phase
and n-hexane, n-hexane-ethyl acetate, ethyl acetate, ethyl acetate-ethanol, and ethanol as mobile phases. The fraction which contained flavonoid compounds was tested its xanthine oxidase inhibition potency using UV
spectrophotometer at λ 290 nm. The absorbance was observed every 10 seconds for 10 minutes for extract and fraction with the concentration of 0.25 ppm - 5 ppm, while allopurinol was determined with the concentration of 0.2 ppm - 3.2 ppm. The result showed that ethyl acetate-ethanol fraction potentially inhibited xanthine oxidase with IC50 value of 5.00 ± 0.06 ppm, while ethanolic extract of Peperomia pellucida (L.) Kunth herb and allopurinol have IC50 value 0.33± 0.07 ppm and 0.84 ± 0.02 ppm respectively. Thus it can be concluded that ethyl acetateethanol fraction had potential as xanthine oxidase inhibitor, but the potential is lower than the ethanolic extract of Peperomia pellucida (L.) Kunth herb.
oai:ojs.jurnal.wima.ac.id:article/4084
2023-03-15T14:35:07Z
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Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 9, No 2 (2022): October; 60-66
Efektivitas Khasiat Penyembuhan Luka Sayat Gel Ekstrak Etanol Daun Ekor Naga (Rhaphidophora pinnata (L.f) Schott) Berdasarkan Analisis Hidroksiprolin
Sani K, Fathnur; Program Studi Farmasi Fakultas Kedokteran dan Ilmu Kesehatan Universitas Jambi
Samudra, Agung Giri; Program Studi Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Bengkulu
Rahman, Havizur; Program Studi Farmasi, Fakultas Kedokteran dan Ilmu Kesehatan Universitas Jambi
Rahman, Ave Olivia; Program Studi Kedokteran, Fakultas Kedokteran dan Ilmu Kesehatan Universitas Jambi
2022-11-16 00:00:00
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/4084
Daun Ekor Naga, Luka, Gel, Hidroksiprolin.
Penulis mengucapkan terima kasih kepada Fakultas Kedokteran dan Ilmu Kesehatan Universitas Jambi untuk Hibah Penelitian Terapan yang bersumber dari dana PNBP Fakultas dengan nomor kontrak 371/UN21.11/PT01.05/SPK/2021.
en
Ekstrak daun ekor naga (Rhaphidophora pinnata (L.f) Schott) merupakan ekstrak yang telah teruji dari penelitian sebelumnya memiliki efek sebagai penyembuh luka sayat, luka bakar dan inflamasi. Efek ini didukung dengan adanya kandungan metabolit skeunder alkaloid, flavonoid, steroid, saponin dan tannin. Efek gel sebagai penyembuh luka sayat juga telah di publish. Tujuan penelitian ini adalah untuk mengetahui kadar hidroksiproline kulit yang mengalami luka sayat setelah pemberian gel ekstrak daun ekor naga selama 14 hari. Metode penelitian yang digunakan merupakan experimental design. Hewan uji yang digunakan masing-masing perlakuan sebanyak 5 ekor hewan uji. Kontrol Positif (Bioplacenton®), Formula 0 (Basis Gel), Formula 1 (Konsentrasi ekstrak daun ekor naga 10%), Formula 2 (Konsentrasi ekstrak daun ekor naga 15%), dan Formula 3 (Konsentrasi ekstrak daun ekor naga 20%). Pengamatan yang dilakukan adalah skrining fitokimia, dan kadar hidroksiproline. Hasil penelitian menunjukkan bahwa formula 2 merupakan formula yang memiliki efektivitas terbaik dalam pembentukan kolagen yaitu sebesar 35,251±4,16 µg/mL. Dimana secara statistik memiliki perbedaan yang bermakna (p<0,05) antar kelompok perlakuan. Kesimpulan bahwa gel ekstrak daun ekor naga memiliki pengaruh terhadap kadar hidroksiprolin pada kasus luka sayat hewan uji.
oai:ojs.jurnal.wima.ac.id:article/2179
2019-10-14T11:39:53Z
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http://journal.wima.ac.id/index.php/JFST/article/view/2179
2019-10-14T11:39:53Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 4, No 2 (2017); 50-56
Formulasi Sediaan Lipstik Ekstrak Air Buah Syzygium cumini Dalam Bentuk Liquid
Sari, Dwi Augusnita; Fakultas Farmasi, Universitas Katolik Widya Mandala Surabaya
Darsono, Farida Lanawati; Fakultas Farmasi, Universitas Katolik Widya Mandala Surabaya
Wijaya, Sumi; Fakultas Farmasi, Universitas Katolik Widya Mandala Surabaya
2019-10-14 12:31:26
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/2179
id
Now-a-days decorative cosmetics are essential needs for women especially lipstick. Lipstick is one of the cosmetics products which is used to increasing the aesthetic of facial make-up. A local tradable fruit called
Syzygium cumini can be used as an alternative in conventional lipstick. Syzygium cumini anthocyanin-rich fruit contain 892 mg anthocyanins per 100g of fresh fruit. The purpose of this research was to find out the increasing of difference (HPMC) in liquid lipstick and to find out influence of the best formulation based on physical test, effectiveness test, safety test and acceptability test. Lipstick in liquid form was chosen because it has advantages such as can be easy to attached, easy to apply and easy to dry so that the formulation required a thickening agent that has properties to fulfill the characteristics of liquid lipstick. HPMC is a thickening agent and can help improve the viscosity of formulation liquid lipstick. The concentration of Syzygium cumini fruit extract was used 20% formulated using HPMC at a concentration of 0.75%; 1% and 2%. The results showed that the increasing concentration of HPMC significantly affect on pH test, viscosity, adhesion, and drying time; the decreasing of spreadness and the smearness of liquid lipstick. The best formula was the formula contained HPMC 2%, based on physical test (viscosity, homogeneity), effectiveness test (smearness, spreadness, stickiness, drying time), safety test and acceptability test.
oai:ojs.jurnal.wima.ac.id:article/4197
2023-03-15T14:35:07Z
JFST:ART
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http://journal.wima.ac.id/index.php/JFST/article/view/4197
2023-03-15T14:35:07Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 9, No 2 (2022): October; 87-93
A review: Utilization of Herbal Medicines in Alzheimer's Disease from Three Plants in Indonesia
Reubun, Yonathan Tri Atmodjo; Sekolah Tinggi Ilmu Kesehatan Medistra Indonesia
2022-11-15 00:00:00
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/4197
Alzheimer; Centella asiatica; Curcuma longa; Moringa oleifera.
id
Alzheimer's disease is a disease in which brain damage is characterized by a decrease in attention, memory, and personality. Personality changes often occur when sufferers become less spontaneous, more apathetic, and withdrawn from their environment. The use of chemical drugs derived from the synthesis of natural drugs is approved for clinical use for Alzheimer's patients. Synthesis from natural materials is carried out because of the many chemical compounds contained in plants which have various biological and pharmacological effects. As for the use of natural medicines that are efficacious as antioxidants, anticoagulants, and anti-inflammatories, they are targets in the prevention of Alzheimer's disease where from these effects they can inhibit the acetylcholinesterase enzyme that plays a role in neurotransmitter damage. This journal review aims to maximize the use of natural medicines that have antioxidant effects from plants such as turmeric (Curcuma longa L.), gotu kola (Centella asiatica L.) and Kelor leaves (Moringa oleifera Lam.) so that these three plants are expected to have an effect. potential in the prevention of Alzheimer's disease which will be discussed extensively.
oai:ojs.jurnal.wima.ac.id:article/4467
2023-08-06T16:20:07Z
JFST:ART
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http://journal.wima.ac.id/index.php/JFST/article/view/4467
2023-08-06T16:20:07Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 10, No 1 (2023): February; 25-31
Formulasi Sediaan Krim Ekstrak Wortel (Daucus carotaL.) dan Uji Aktivitasnya sebagai Tabir Surya secara In Vitro
Hidayati, Rakhmi; Institut Teknologi Kesehatan Cendekia Utama Kudus
Sari, Dessy Erliani Mugita; Institut Teknologi Kesehatan Cendekia Utama Kudus
Noor, Nailissa’adah; Institut Teknologi Kesehatan Cendekia Utama Kudus
2023-05-30 01:13:33
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/4467
Wortel (Daucus carota L.), krim tabir surya, optimasi emulgator span 60 dan tween 80.
Institut Teknologi Kesehatan Cendekia Utama Kudus
en
Wortel memiliki kandungan β-karoten yang berpotensi sebagai tabir surya. Krim merupakan sediaan yang memberi rasa nyaman pada penggunaan kulit, sehingga dilakukan pengembangan formula sediaan krim ekstrak wortel (Daucus carota L.) sebagai krim tabir surya. Penelitian ini bertujuan mengoptimasi formula sediaan krim ekstrak wortel dengan variasi nilai HLB kombinasi emulgator Span 60 dan Tween 80. Ekstrak diformulasikan ke dalam krim yang dibagi menjadi tiga formula yaitu formula I, formula II, formula III berturut-turut 11,395; 9,335; dan 10,365. Penentuan formula terbaik didapatkan dari evaluasi sediaan krim yang meliputi uji organoleptis, uji homogenitas, uji pH, uji daya sebar, uji daya lekat dan uji SPF.Analisis data menggunakan uji One Way Anova hasilnya menunjukkan bahwa penggunaan emulgator kombinasi span 60 dan tween 80 dapat menghasilkan sediaan krim yang memenuhi mutu fisik yang baik. Uji SPF diuji menggunakan uji Kruskal Wallis dilanjutkan uji Mann Whitney hasilnya formula 1 memiliki serapan SPF yang paling tinggi artinya optimasi emulgator span 60 dan tween 80 dapat mempengaruhi aktivitas kadar tabir surya pada krim. Hasil penelitian ini krim variasi nilai HLB kombinasi emulgator span 60 dan tween 80 dengan nilai HLB 11,365 lebih sesuai untuk formula sediaan krim ekstrak wortel karena memiliki serapan SPF tertinggi.
oai:ojs.jurnal.wima.ac.id:article/2184
2019-10-14T11:39:53Z
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2019-10-14T11:39:53Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 4, No 2 (2017); 82-87
Profil Terapi Diare Akut pada Pasien Anak Rawat Inap di Rumah Sakit Bhayangkara Surabaya
Sandra, Pipit; Fakultas Farmasi, Universitas Katolik Widya Mandala Surabaya
Hasmono, Didik; Rumah Sakit Bhayangkara Surabaya dan Fakultas Farmasi, Universitas Airlangga Surabaya
Kasih, Elisabeth; Fakultas Farmasi, Universitas Katolik Widya Mandala Surabaya
Hartono, Ruddy; Rumah Sakit Bhayangkara Surabaya
2019-10-14 12:31:26
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/2184
id
Acute diarrhea in children is defined as defecation more than 3 times per day, with changes in the consistency of feces into fluids with or without mucus and blood lasting either less than a week or up to 14 days, but not more than 14 days in children or infant. Treatment of acute diarrhea can shorten the duration of diarrhea and eradicate the organism which causes the disease. The purpose of this research was to analyze the profile of acute diarrhea treatment in hospitalized pediatric patients at Bhayangkara Hospital Surabaya including the type, dosage, route and the timing of administration which is related to the patient’s medical record data. This research is an observational study in the form of retrospective study in patients with acute diarrhea with a t o t a l sampling technique. The results showed the most commonly used medications for acute diarrhea in children were parenteral rehydration fluid of KDN-1 of (41 patients, 80%) with the most widely used dose (500 cc / 4 hours → 1000 cc / 24 h) IV, t h e pa t t e r n o f single antibiotic use was (43 patients, 84%), the penicillin group, ampicillin, as many as (22 patients, 44%) with the most widely used dose (4 x 250 mg) IV, the most commonly prescribed single antibiotic when discharged from the hospital was cephalosporin group, cefixime, with 17 patients (33%), with the most widely used dose (2 x 20 mg) P.O, sinbiotic with (36 patients, 70%) and the most widely used was dose (1 x 1 sachet) P.O, zinc with (49 patients, 96%) and the most widely used was dose (1 x 1 cth) P.O, vitamin A with (21 patients, 41%), and the most widely used was dose (1 x 500 IU) P.O, antidiarrhea dioctahedral smectite was (43 patients, 84%) and the most commonly used was dose (3 x 1/3 sachets) P.O.
oai:ojs.jurnal.wima.ac.id:article/695
2015-06-19T09:14:35Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/695
2015-06-19T09:14:35Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 2, No 1 (2015)
Perbandingan Kadar Likopen pada Manilkara zapota L., Gnetum gnemon L., Ipomoea batatas L., dan Momordica charantia L. dengan Menggunakan Campuran Solven n-Heksan, Aseton, dan Etanol
R, Nur Syafaatur; a)Fakultas Farmasi, Institut Ilmu Kesehatan Bhakti Wiyata Kediri
R, Panji
W, Reka
M, Rika
NHS, Cikra
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/695
en
Lycopene, a member of the carotenoid family of phytochemicals is a lipid soluble antioxidant that is
synthesized by many plants and microorganisms but not by animals and human. Lycopene is a natural
pigment that imparts red color totomato, guava, rosehip, watermelon, and pink grapefruit. Separation of
lycopene from tomato fruit using conventional solvents can be carried out by liquid-liquid extraction method,
using a mixture of n-hexane, acetone and ethanol as a solvent. Lycopene assay can be performed using a
spectrophotometer method. Sapodilla fruit, leather melinjo, is ripe, and Cilembu sweet potato are some
examples of plants that have a yellowish red pigment. This study aimed to investigate and compare the
levels of lycopene contained in Cilembu sweet potato (Ipomoea batatas L.), fruit sapodilla (Manilkara zapota
L.), bitter melon fruit (Momordica charantia L.), as well as fruit leather melinjo (Gnetum gnemon L.) using
conventional solvent extraction method with a mixture of n-hexane, acetone, and ethanol. Data was analyzed
by one-way ANOVA, followed by LSD test at 5% level test. The results showed that the concentration of
lycopene in the fresh Cilembu sweet potatoes, fresh sapodilla fruit, fresh bitter melon fruit, and fresh fruit
peel melinjo is 0.038 ± 0.003 mg/g, 0.085 ± 0.009 mg/g, 0.054 ±0.004 mg/g, 0.015±0.000 mg/g. Fresh
sapodilla fruit has the highest lycopene content of 0.085 ±0.009 mg/g.
oai:ojs.jurnal.wima.ac.id:article/700
2015-06-19T10:45:59Z
JFST:ART
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2015-06-19T10:45:59Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 2, No 1 (2015)
Efek Farmakologi Infusa Biji Melinjo (Gnetum gnemon L.) Sebagai Antihiperglikemia pada Mencit (Mus musculus) yang Diinduksi Dextrosa Monohidrat 40%
Feri Ira W(, Cita Dwi
NHS, Cikra Ikhda
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/700
en
Diabetes mellitus is a group of disorders in which the body's carbohydrates, fats, and proteins metabolism was
disordered and it has many other causes. This study objectives was to determine the pharmacological effects of
melinjo infusion in decreasing blood glucose levels in mice (Mus musculus). This study using mice (Mus musculus)
aged 2-3 months, 20 grams body weight. A total of 12 mice were divided into 4 groups, each was given dextrose
monohydrate 40%. Group I as a negative control (CMC Na 1%), group II as positive control (glibenclamide), group
III (melinjo infusion 25% w/v ) and group IV (melinjo infusion 50% w/v). The data obtained from the examination
of blood glucose levels for 24 hours with an interval of 6 hours. Melinjo (Gnetum gnemon L.) infusion dose that
can lower blood glucose levels in hyperglycemic mice is 50%. Repeated analysis of the data was done using ANOVA
Duncan's test. The results showed that the dose 50% of infusion melinjo have a pharmacological effect in
decreasing blood glucose levels by 33,41% and it was different significantly (p>0.01) compared to glibenclamide.
oai:ojs.jurnal.wima.ac.id:article/4132
2023-08-06T16:20:07Z
JFST:ART
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2023-08-06T16:20:07Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 10, No 1 (2023): February; 65-71
Cosmetovigilance: “Beautiful Is Pain”
Zainudin, Mochamad Yusuf; Master of Pharmacy, Faculty of Mathematics and Natural Science Islamic University of Indonesia
Chabib, Luthfi; Faculty of Mathematics and Natural Sciences, Universitas Islam Indonesia
Jl. Kaliurang No.Km. 14,5, Krawitan, Umbulmartani, Kec. Ngemplak, Kabupaten Sleman, Daerah Istimewa Yogyakarta 55584, Indonesia
2023-02-27 00:00:00
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/4132
Cosmetovigilance; Cosmetics; Adverse Drug Reactions (ADRs)
en
Cosmetics are defined as preparations used on the skin, mouth, nails, hair and eyes with the aim of increasing attractiveness, providing fragrance or protection of body odor, cleaning. The difference between drugs and cosmetics is sometimes not clear. Regulations covering cosmetic products that discuss the products used are safe and can be used by healthy people, product safety, and efficacious from cosmetic products approved by national authorities before being sold to consumers. Monitoring the safety of cosmetic products, and is a very important component of public health activities. After sales supervision of cosmetic products must be widely spread in the community, and problems related to these products can be solved, and identified in order to achieve a safe product. In August 2022, a search for the term cosmetovigilance in the Google search database returned 38 articles Family physicians and expert care practitioners, have a very useful role in providing an understanding of Adverse Drug Reactions (ADRs) caused by cosmetic products, and with such occurrences they can encourage patients to report Adverse Drug Reactions (ADRs) to the appropriate officials. authorized. Raise awareness of the new concept and become valuable commentary on public health at large.
oai:ojs.jurnal.wima.ac.id:article/2234
2019-11-04T08:17:59Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/2234
2019-11-04T08:17:59Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 6, No 2 (2019); 74-83
Standarisasi Spesifik dan Non Spesifik Simplisia dan Ekstrak Etanol Bawang Putih Tunggal Terfermentasi (Allium sativum Linn.)
Vernanda, Renna Yulia; Fakultas Farmasi, Universitas Katolik Widya Mandala Surabaya
Puspitasari, Maria Revina; Fakultas Farmasi, Universitas Katolik Widya Mandala Surabaya
Satya, Hadianto Nur; Fakultas Farmasi, Universitas Katolik Widya Mandala Surabaya
2019-10-31 22:14:29
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/2234
id
Garlic that has undergo a fermentation process (Black garlic) has been shown to have a total content of flavonoids and polyphenols greater than fresh garlic. One of garlic varieties is single bulb Garlic (Allium sativum Linn.) which contains only one small bulb. This study aims to determine specific and non specific standardization of dried fermented single bulb Garlic and ethanol extract of fermented single bulb Garlic (Allium sativum Linn.). Samples were collected from three different regions: Temanggung, Bromo and Banyuwangi. The results of the study showed that dried fermented single bulb garlic have round shape oval, brown color blackish, and aromatic odor; water soluble content >25%, ethanol soluble content >26%, total polyphenols >4.5% b/b, total flavonoids >0.6% b/b; dred fermented single bulb Garlic contain polyphenols, flavonoids, and saponins; total ash content 2% b/b; the ethanol extract contain polyphenols and flavonoids; total ash content
oai:ojs.jurnal.wima.ac.id:article/716
2015-10-28T16:51:03Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/716
2015-10-28T16:51:03Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 2, No 2 (2015)
Efek Antifertilitas Fraksi n-Heksana, Fraksi Kloroform, dan Fraksi Metanol Biji Pepaya (Carica papaya L.) Terhadap Tikus Jantan Galur Wistar
Muslichah, Siti
., Wiratmo
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/716
en
Rendahnya partisipasi pria dalam program Keluarga Berencana disebabkan karena terbatasnya pilihan kontrasepsi untuk pria. Penelitian ini bertujuan untuk mengevaluasi potensi fraksi n-heksana, fraksi kloroform, dan fraksi metanol biji pepaya sebagai bahan kontrasepsi. Fraksi-fraksi tersebut diberikan secara oral dengan dosis masing-masing 100 mg/kgBB selama 20 hari. Sebanyak 20 ekor tikus jantan dengan berat badan 200-300 g berumur 2-2,5 bulan dikelompokkan menggunakan Rancangan Acak Lengkap. Hasil penelitian menunjukkan terjadinya penurunan jumlah, motilitas, viabilitas serta peningkatan abnormalitas spermatozoa yang signifikan dibandingkan kontrol. Hasil tersebut menunjukkan bahwa ekstrak biji C. papaya mempunyai efek terhadap reproduksi pria yang menunjukkan potensi tanaman ini sebagai pengatur kesuburan pria.
Kata kunci: biji Carica papaya, motilitas sperma, jumlah sperma, antifertilitas, abnormalitas sperma.
oai:ojs.jurnal.wima.ac.id:article/5082
2024-01-29T05:16:57Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/5082
2024-01-29T05:16:57Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 10, No 2 (2023): October; 99-107
Formulasi Dan Uji Aktivitas Antioksidan Krim Kombinasi Ekstrak Biji Kopi Hijau (Coffea canephora var Robusta) dan Ekstrak Daun Teh Hijau (Camellia sinensis (L.))
http://journal.wima.ac.id/index.php/JFST/article/download/5082/14908
Lamsari, Lamsari; Fakultas Farmasi, Universitas Pancasila, Jakarta
Taurhesia, Shelly; Fakultas Farmasi, Universitas Pancasila, Jakarta
Djamil, Ratna; Fakultas Farmasi, Universitas Pancasila, Jakarta
2023-10-29 00:00:00
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/5082
Kopi Hijau, Teh Hijau, Antioksidan, Krim
ind
Kopi robusta mengandung senyawa alkaloid, flavonoid, saponin, tanin, kafein dan fenol, sedangkan daun teh hijau mengandung senyawa katekin. Senyawa fenol pada kopi dan katekin pada daun teh hijau memiliki aktivitas sebagai antioksidan. Penelitian ini bertujuan untuk mengembangkan formulasi krim dari kombinasi ekstrak biji kopi hijau dan daun teh hijau, yang memiliki aktivitas antioksidan. Biji kopi hijau diekstraksi secara maserasi kinetik menggunakan pelarut kombinasi Isopropanol : air (60:40) sedangkan daun teh hijau diekstraksi dengan pelarut Etanol 70%. Setelah diperoleh ekstrak kental, kemudian dilakukan uji mutu ekstrak serta uji aktivitas antioksidan menggunakan metode DPPH. Nilai IC50 ekstrak biji kopi hijau (EBKH) adalah 22.37 ppm, ekstrak daun teh hijau (EDTH) adalah 7.02 ppm, sedangkan kombinasi EBKH : EDTH (1:1) adalah 11.59 ppm. Kemudian dikembangkan formula krim mengandung kombinasi kedua ekstrak dengan variasi perbandingan EBKH : EDTH = 1:2 (F1) ; 1:1 (F2) dan 2:1 (F3). Diperoleh Krim tipe M/A, berwarna putih kekuningan, berbau khas, tekstur lembut, homogen, rentang pH 7.3 – 7.5, viskositas 190.000 – 205.000 cPs, diameter daya sebar 5.9 – 6.3 cm, dan nilai aktivitas antioksidan tertinggi diperoleh dari F1 sebesar 25.62 ppm. Ketiga formula stabil pada suhu 40 °C selama 4 minggu penyimpanan, dan hasil uji iritasi menunjukkan F2 memberikan respon iritasi sangat ringan.
oai:ojs.jurnal.wima.ac.id:article/2341
2020-02-05T14:26:16Z
JFST:ART
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http://journal.wima.ac.id/index.php/JFST/article/view/2341
2020-02-05T14:26:16Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 1, No 1 (2013); 1-8
Bioaktivitas Produk Fermentasi Monascus
Srianta, Ignatius; Food Technology Study Program, Faculty of Agricultural Technology Widya Mandala Catholic University Surabaya
Widharna, Ratna Megawati; Faculty of Pharmacy, Widya Mandala Catholic University Surabaya
Kardono, Leonardus Broto S.; Chemistry Research Center, Indonesian Institute of Sciences, PUSPIPTEK Area, Serpong-Tangerang
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/2341
id
Monascus-fermented product has been used traditionally in Asian countries as food and medicine. Traditionally, Monascus-fermented rice was produced with cultivate Monascus sp. on steamed rice medium. During fermentation, Monascus sp. produce various metabolites. Beside pigments, Monascus sp. also
produces monacolin K, monascin, dimerumic acid, etc which possess positive health impacts. Recent studies reported that Monascus sp. could grow on non rice medium i.e. soybean, dioscorea, adlay etc. This paper is a review of bioactivities of Monascus-fermented products including anti-inflammatory, anti hypercholesterolemic, anti hyperlipidemia, anti hypertensive, antioxidant and anti diabetes activities.
oai:ojs.jurnal.wima.ac.id:article/721
2015-10-28T16:51:04Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/721
2015-10-28T16:51:04Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 2, No 2 (2015)
Formulasi Sediaan Pemerah Pipi dari Ekstrak Kelopak Bunga Rosella (Hibiscus sabdariffa Linn.) Sebagai Pewarna dalam Bentuk Compact Powder
Bindharawati, Nina
Darsono, Farida Lanawati
Wijaya, Sumi
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/721
en
Latar belakang :Dewasa ini, penyalahgunaan pewarna tekstil didalam sediaan pemerah pipi sangat mengkuatirkan. Hal tersebut mengakibatkan dibutuhkannya suatu produk pemerah pipi yang aman dan mempunyai manfaat yang sesuai dengan penggunaannya.
Metode :Ekstrak kelopak bunga rosella dijadikan sebagai pewarna dengan konsentrasi 30 % dan digunakan isopropil miristat sebagai pengikat dengan berbagai konsentrasi. Formula I 0,5%, formula II 0,75% dan formula III 1%. Ekstrak kelopak bunga rosella diperoleh dengan cara maserasi etanol 96% dengan penambahan 3% asam asetat glasial, lalu diuapkan di penangas air dengan suhu dibawah 70º C. Sediaan pemerah pipi compact powder dibuat dengan cara kempa kering.
Hasil dan diskusi :Rendemen ekstrak yang diperoleh sebesar 25,17%. Pada hasil pengamatan ditunjukkan bahwa sediaan dengan konsentrasi isopropil miristat 0,5% lebih rapuh atau mudah pecah. Pada uji pH, sediaan yang memenuhi persyaratan adalah formula I dan formula II. Pada uji oles, sediaan dengan konsentrasi 1% tidak dapat ditempelkan pada kuas dan tidak dapat dilekatkan pada kulit.
Kesimpulan :Ekstrak kelopak bunga rosella dapat dijadikan salah satu pewarna alternatif yang baik dengan konsentrasi isopropil miristat yang terbaik adalah 0,75%.
Kata kunci :compact powder, isopropil miristat, pemerah pipi, rosella.
oai:ojs.jurnal.wima.ac.id:article/2346
2020-02-05T14:36:46Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/2346
2020-02-05T14:36:46Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 1, No 1 (2013); 31-35
Fraksinasi dan Identifikasi SenyawaAntioksidan pada Eksb-ak Etanol buah Goji beny(Lycium barbarum linn.) secaraKromatografi Kolom
Albrian, Diga; Faculty of Pharmacy, Widya Mandala Catholic University Surabaya
Wijaya, Sumi; Faculty of Pharmacy, Widya Mandala Catholic University Surabaya
Setiawan, Henry Kurnia; Faculty of Pharmacy, Widya Mandala Catholic University Surabaya
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/2346
id
Goji berry fruit (Lycium barbarum), familia Solanac'eae, is a red berry fruit. The chemical compounds contained in this fruit are polysaccharides, zeaxanthin and beta-carotene. Activity of the chemical compounds is still considered as a family of antioxidant compounds, which are used as a medicine to cure the diseases caused by the presence of free radicals such a~ atherosclerosis, cancer, liver cirrhosis, hypertension and diabetes. The research will be carried on fractionation and identification of the ethanol extract of Goji berry fruit to obtain compounds that have antioxidant power using chromatographic column method and DPPH method. The isolated compounds will be identified using methods phytochemica/s screening, TLC, UV-Vis spectrophotometer and infrared spectrophotometer. The result showed that secondary metabolites of Goji berry fruit which are potential as antioxidant compound were flavonoid (flavono/s or flavones). The isolated compound had higher antioxidant activity compare to the ethanol extract of Goji berry fruit Flavonoids are the major compounds that have antioxidant capacity. Whereas, the ethanol fraction of Goji berry fruits has the best antioxidant activity than the ethanol extract Keywords: Antioxidant, Goji berry, DPPH and chromatographic column
oai:ojs.jurnal.wima.ac.id:article/808
2016-06-08T14:50:07Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/808
2016-06-08T14:50:07Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 2, No 1 (2015)
Penetapan Kadar Hidrokuinon pada Krim Pemutih Wajah A dan B dengan Metode Kolorimetri
Dian M., Lailul
INHS, Cikra
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/808
en
Hidrokuinon adalah bahan aktif yang dapat mengendalikan produksi pigmen yang tidak merata, tepatnya
berfungsi untuk mengurangi atau menghambat pembentukan melanin kulit. Penggunaan hidrokuinon
sebagai bahan tambahan krim pemutih kulit yaitu dengan kadar kurang dari 2%. Pemakaian hidrokuinon
yang berlebih memberikan efek samping yang sangat merugikan. Penelitian ini bertujuan untuk
mengetahui apakah terdapat kandungan hidrokuinon yang berlebih dalam sampel krim pemutih wajah A
dan B. Analisis hidrokuinon dalam sampel krim dilakukan dengan metode kolorimetri menggunakan
pereaksi floroglusin dan pengukuran serapan dengan spektrofotometri UV-Vis. Analisis data dilakukan
dengan Independent Samples T Test pada taraf uji 5%. Hasil penetapan kadar dari sampel krim A dan
krim B secara berurutan adalah 0,404±0,436 mg/L dan 0,872±0,000 mg/L. Sampel krim pemutih wajah B
menunjukkan kadar hidrokuinon terbesar (0,872±0,000 mg/L) dan persentase kadar hidrokuinon yang
diperoleh adalah 0,35%. Hasil data uji statistik dengan menggunakan Independent Samples T Test
dapat diketahui bahwa dari setiap sampel krim pemutih wajah mempunyai perbedaan kadar yang bermakna
antarkelompok sampel krim dengan nilai signifikan p=0,032 (p
oai:ojs.jurnal.wima.ac.id:article/2393
2022-09-24T02:32:37Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/2393
2022-09-24T02:32:37Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 7, No 1 (2020): Februari; 27-35
Studi Penggunaan Carboplatin untuk Penderita Kanker Payudara di RUMKITAL Dr. Ramelan Surabaya
Giovani, Alfin; Fakultas Farmasi, Universitas Katolik Widya Mandala Surabaya, Surabaya
Hasmono, Didik; Fakultas Farmasi, Universitas Airlangga Surabaya
Surdijati, Siti; Fakultas Farmasi, Universitas Katolik Widya Mandala Surabaya
Semedi, Joko; Rumah Sakit Angkatan Laut Dr. Ramelan Surabaya
2020-03-10 00:00:00
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/2393
id
Cancer is an abnormal growth of new cells that grow beyond normal limits. Cancer can metastasize by attacking parts of the body and spread to other organs. The prevalence of cancer Indonesian’s people in 2013 is estimated
at 347,792. Breast cancer is the most common cancer in women with a percentage of 23%. Breast cancer is the second most common cancer with death after cervical cancer. Breast cancer is divided according to histologic subtype to Ductal Carcinoma in Situ (DCIS) and Lobular Carcinoma in Situ (LCIS). Carboplatin is a platinum analog cancer drug that belongs to the class of antineoplastic agents. Carboplatin doses used in AUC 6 (i.v) breast cancer chemotherapy for 1 cycle with 21 days to 6 cycle times. This research was conducted observasional with descriptive research design and retrospective data retrieval. The purpose of this study was to know the profile of carboplatin as an anti-cancer drug that is expected to provide safe treatment. This research was conducted at Dr. RUMKITAL Ramelan Surabaya with the number of inclusion of 30 patients in the period January 1, 2017 - December 31, 2017. From the results of this study obtained the use of single carboplatin as much as 7% and a combination of 93%. Patients with chemotherapy administered without surgery and surgery were 73% and 27%, respectively. Toxicity of nausea and vomiting happen as much as 42% and pain as much as 19%.
oai:ojs.jurnal.wima.ac.id:article/2365
2020-10-31T22:36:08Z
JFST:ART
v2
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2020-10-31T22:36:08Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 7, No 2 (2020): Oktober; 70-73
Formulasi Pasta Gigi Ekstrak Etanolik Herba Ashitaba (Angelica keiskei)
Juliantoni, Yohanes; Program Studi Farmasi, Universitas Mataram, Mataram
Subaidah, Windah Anugrah; Program Studi Farmasi, Universitas Mataram, Mataram
Wirasisya, Dyke Gita; Program Studi Farmasi, Universitas Mataram, Mataram
2020-10-30 00:00:00
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/2365
ashitaba, Streptococcus mutans, toothpaste
Universitas Mataram
en
Ashitaba (Angelica keiskei) memiliki khasiat sebagai antibakteri Streptococcus aureus mutans yang merupakan penyebab karies gigi. Pasta gigi merupakan salah satu bentuk sediaan untuk pembersih gigi. Penelitian ini dilakukan untuk membuat formulasi ekstrak herba ashitaba dalam bentuk pasta gigi. Metode maserasi digunakan untuk mengekstraksi ashitaba dengan larutan penyari etanol 96%. Pasta gigi dibuat dengan tiga variasi konsentrasi dari karbopol 940 secara berurutan yaitu 1% (formulasi I), 2% (formulasi II), dan 3% (formulasi III). Parameter uji formula pasta gigi meliputi pH, homogenitas, tinggi busa, dan uji hedonik. Rendemen ekstrak etanol ashitaba diperoleh sebesar 18,13%. Hasil uji sifat fisik tiga sediaan pasta gigi menunjukkan bahwa ketiga formula homogen, memenuhi syarat pH, dan Formula II memiliki nilai respon kesukaan yang paling baik.
oai:ojs.jurnal.wima.ac.id:article/2005
2019-10-14T10:40:55Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/2005
2019-10-14T10:40:55Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 6, No 1 (2019); 1-5
Prediksi Farmakokinetik, Toksisitas, dan Aktivitas Enzim Protease HIV-1 Inhibitor dari Daun J. gendarussa
Widodo, Agustinus; Jurusan Farmasi Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Tadulako Palu
2019-04-23 14:17:18
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/2005
id
Justicia gendarussa Burm.f. (Acanthaceae) has been known to have anti-HIV activity. This study was conducted to determine the interaction of flavonoids (gendarusin A, B, C, D, and E) on the J. gendarussa leaves against HIV-1 protease receptor. It is expected that this research will provide scientific information on the development of J. gendarussa leaves as an anti-HIV drug. This study used in silico testing methods with FAF-Drugs4 to predict the ADMET (absorption, distribution, metabolism, and excretion–toxicity), and Molegro Virtual Docker (MVD) to predict the activity of five gendarusin compounds to the receptor of HIV-1 protease (PDB ID: 4HLA). The activity prediction was reflected by hydrogen bond and steric bond visible in MVD program with amino acid residue of the receptor of HIV-1 protease. Gendarusin compounds had good oral bioavailability and were not toxic, and from molecular docking test, it was found that gendarusin of J. gendarussa leaves could inhibit the activity of HIV protease enzyme. Gendarusin of J. gendarussa has potential as an anti-HIV.
oai:ojs.jurnal.wima.ac.id:article/2794
2020-10-31T22:36:10Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/2794
2020-10-31T22:36:10Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 7, No 2 (2020): Oktober; 93-97
Pengaruh Komunikasi, Informasi dan Edukasi (KIE) terhadap Tingkat Pengetahuan Pasien Pediatri Penyakit Diare di Puskesmas “X” Wilayah Surabaya Timur
Missa, Margareta Maria Alacoque; Puskesmas “X” Wilayah Surabaya Timur
Surdijati, Siti; Puskesmas “X” Wilayah Surabaya Timur
Trisnani, Retno; Universitas Katolik Widya Mandala Surabaya
2020-10-30 00:00:00
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/2794
Tingkat Pengetahuan; Diare; KIE; Pengasuh Pasien
in
Diare merupakan salah satu masalah kesehatan yang masih sering menjadi Kejadian Luar Biasa ( KLB ) karena dapat menyebabkan kematian. Penyebab utama kematian diare adalah dehidrasi akibat kehilangan cairan dan elektrolit melalui feses. Penyakit diare masih menjadi masalah global dengan derajat kesakitan dan kematian yang tinggi di berbagai negara terutama di negara berkembang. Penelitian ini bertujuan untuk mengetahui
pengaruh dari Komunikasi Informasi dan Edukasi (KIE) terhadap tingkat pengetahuan pasien penyakit diare di Puskesmas “X” Wilayah Surabaya Timur periode Maret hingga Agustus 2019. Penelitian bersifat deskriptif dan Analisis metode paired sample T test dengan pengambilan data secara purposive sampling. Sumber data adalah pasien pediatri penyakit diare dengan rentang usia 0-17 tahun. Hasil penelitian dari 40 responden yang
memenuhi kriteria inklusi, yaitu jumlah responden berjenis kelamin laki-laki (7,5%) dan perempuan (92,5%), sebagian besar berusia 31-35 tahun (47,5%) dan 25-30 tahun (27,5%). Hasil penelitian menunjukkan bahwa dari
40 responden yang memenuhi kriteria inklusi sebelum KIE diperoleh tingkat pengetahuan baik (15%), tingkat pengetahuan cukup (77 %) , dan tingkat pengetahuan kurang sebesar (7,5 %). Sesudah KIE diperoleh tingkat
pengetahuan baik (75%), dan tingkat pengetahuan cukup (25%). Berdasarkan hasil penelitian terdapat hubungan antara tingkat pengetahuan dengan pemberian Komunikasi Informasi dan Edukasi (KIE) terhadap pasien pediatri penyakit diare yang dilakukan di puskesmas “X” Wilayah Surabaya Timur.
oai:ojs.jurnal.wima.ac.id:article/2010
2019-10-14T10:40:55Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/2010
2019-10-14T10:40:55Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 6, No 1 (2019); 34-37
Analisis Vitamin B6 (Piridoksin) pada Sediaan Tablet Multivitamin Neurotropik Menggunakan Spektrofotometri UV-Vis
Maritha, Vevi; Sekolah Tinggi Ilmu Kesehatan Bhakti Hudasa Mulia Madiun, Jawa Timur, Indonesia
2019-04-23 14:17:18
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/2010
id
Vitamin B6 analysis in neurotrophic multivitamin tablet preparations requires a simple, fast and cheap method. UV-Vis spectrophotometer is having these criteria. Vitamin B6 analysis using UV Vis spectrophotometry is very quick so that the substance degradation can be inhibited and the results obtained will be accurate. Selection of single maximum wavelength for vitamin B6 will be able to separate with other components of vitamins B1 and B6 although all three are soluble in water. The optimal condition of vitamin B6 analysis in neurotropic multivitamin samples was using UV-Vis spectrophotometry at 325 nm wavelength. The solvent used is water. The calibration result curve in series of 60 ppm, 70 ppm, 80 ppm, 90 ppm, 100 ppm, 110 ppm, 120 ppm and 130 ppm have r value of 0, 9965. Determination of vitamin B6 levels using three brands of neurotrophic multivitamin samples performed. The measured theoretical level was 100 ppm, whereas the recovery of neurotropic multivitamin A samples were 98.24 ppm, 95 ppm and 95.78 ppm respectively with SD 1.69. The theoretical content of vitamin B6 in the neurotrophic multivitamin sample of B brand was 100 ppm, whereas the recovery was 99 ppm, 102 ppm and 98 ppm with SD 1.15. Determination of vitamin B6 concentration in the neurotropic multivitamin brand C the measured theoretical level was 100 ppm, while the recovery was 102 ppm, 101 ppm and 99 ppm with SD
value of 1.53. The recovery of vitamin B6 level determination has been in accordance with AOAC requirements, ie for 100% ppm% analytical calculation 90-107%. The primary SD values of the three neurotrophic multivitamin samples of less than 2 indicate that vitamin B6 levels are acceptable. The results of this study indicate that vitamin B6 in a neurotrophic multivitamin sample can be analyzed using UV-VIS spectrophotometry at a wavelength of 325 nm using a water solvent.
oai:ojs.jurnal.wima.ac.id:article/3087
2022-09-24T02:31:56Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/3087
2022-09-24T02:31:56Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 8, No 1 (2021): Februari; 13-20
Standarisasi Simplisia Daun Kenikir (Cosmos caudatus Kunth) Dari Tiga Daerah Berbeda
Jannah, Miftahul; Universitas Katolik Widya Mandala Surabaya
Wijaya, Sumi; Universitas Katolik Widya Mandala Surabaya
Setiawan, Henry Kurnia; Universitas Katolik Widya Mandala Surabaya
2021-03-21 11:41:12
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/3087
Simplisia; daun kenikir; profil standarisasi; spesifik; non spesifik
id
Kenikir dipercaya sebagai obat penurun suhu tubuh, memperbaiki sirkulasi darah, mengobati diabetes, sebagai anti-aging dan menjaga kekuatan tulang. Saat ini telah banyak produk serbuk daun kenikir dalam bentuk kapsul di pasaran, tetapi belum ada data standarisasi dari simplisia daun kenikir, sehingga penelitian ini dilakukan bertujuan untuk mendapatkan profil standarisasi spesifik dan non-spesifik dari simplisia daun kenikir. Parameter spesifik terdiri dari identitas simplisia, organoleptis, kadar sari laut air, kadar sari larut etanol, penetapan profil kromatografi dengan menggunakan KLT, penetapan profil spektrum dengan menggunakan spektrofotometer infrared dan UV-Vis serta penetapan kadar senyawa metabolit sekunder. Parameter non spesifik meliputi susut pengeringan, kadar abu total, kadar abu tak larut asam, kadar abu larut air, pH, dan persen bahan asing. Data yang diperoleh merupakan data deskriptif yang diperoleh dari 3 lokasi berbeda. Hasil pengamatan mikroskop daun segar kenikir menunjukkan tipe berkas pembuluhnya adalah kolateral terbuka, jaringan bunga karang atau palisade, dengan tipe stomata anomositik, rambut penutup non-glandullar, kristal Ca-oksalat bentuk pisma dan tipe daun dorsiventral. Hasil kadar sari larut etanol > 23,3%, kadar sari larut air > 13,15%. Hasil skrining fitokimia menunjukkan adanya senyawa flavonoid, saponin, polifenol, steroid dan triterpenoid. Hasil pengamatan profil kromatogram secara KLT dengan fase diam silika gel F254 dan fase gerak yang terpilih adalah n-heksan : etil asetat (7:3). Hasil penetapan kadar flavonoid total > 1,30%, fenol > 2,18%. Nilai susut pengeringan ≤13,5%, sedangkan hasil kadar abu total ≤6,0% dengan kadar abu larut air ≤5,0% dan kadar abu tak larut asam ≤2,0%, pH simpisia untuk pelarut air yaitu 6- 7 dan pada pelarut etanol 4 – 6.
oai:ojs.jurnal.wima.ac.id:article/2049
2019-05-23T12:42:36Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/2049
2019-05-23T12:42:36Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 5, No 1 (2018); 6-10
Studi Penggunaan Natrium Valproat Kurang Dari Tiga Bulan Terhadap Magnesium Serum Dan Jumlah Kejang Pasien Epilepsi Di RSUD Dr. Soetomo
Latuasan, Ivana Rahayu; Fakultas Farmasi, Universitas Katolik Widya Mandala Surabaya
Sugianto, Paulus; Fakultas Kedokteran Universitas Airlangga Surabaya;
Departemen Neurologi Rumah Sakit Umum Daerah Dr. Soetomo Surabaya,
Kasih, Elisabeth; Fakultas Farmasi, Universitas Katolik Widya Mandala Surabaya
Octavia, Evi; Instalasi Farmasi Rumah Sakit Umum Daerah Dr. Soetomo Surabaya
2018-05-23 00:00:00
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/2049
id
Epilepsy is a brain disorder characterized by a tendency to cause continuous epilepsy attacks with neurobiological, cognitive, psychological and social consequences. The appearance of temporary signs or symptoms is caused by abnormal and excessive neuron activity in the brain. Sodium valproate can be used as epilepsy therapy because it is effective in inhibiting seizures, partial seizures, and tonic-clonic seizures. The mechanism of action of sodium valproate in the treatment of epilepsy is to increase the inactivation of Na + channels, thereby reducing the nerve's ability to transmit electric charges. Magnesium is a potential modulator of seizure activity because of its ability to inhibit excitation through N-methyl D-aspartate receptors. The aim of this study was to determine serum magnesium levels with sodium valproate treatment and the number of seizures as well as to identify drug-related problems in epilepsy patients who were less than three months old. The research was conducted in the Electroencephalography Room of the Regional Hospital Dr. Soetomo Surabaya by using observational methods in
the form of prospective studies using data collection sheets and questionnaires. Samples were taken from July 1 to September 30, 2017. Based on laboratory results, the average magnesium content of patients with seizures was 2.22 mg / dL while non-seizure patients were 2.08 mg / dL. The conclusion of this study is that the use of sodium valproate does not affect magnesium levels in epilepsy patients and epilepsy patients who get sodium valproate therapy have a lower risk of seizures than those who do not get sodium valproate medication.
oai:ojs.jurnal.wima.ac.id:article/3044
2021-11-26T14:50:54Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/3044
2021-11-26T14:50:54Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 8, No 2 (2021): Oktober; 69-77
Fenomena Pengaruh Terapi Farmakologi Terhadap Kepatuhan Berobat dalam Perspektif Pasien Diabetes Melitus Tipe 2
http://journal.wima.ac.id/index.php/JFST/article/download/3044/7587
http://journal.wima.ac.id/index.php/JFST/article/download/3044/7588
http://journal.wima.ac.id/index.php/JFST/article/download/3044/7589
http://journal.wima.ac.id/index.php/JFST/article/download/3044/7590
http://journal.wima.ac.id/index.php/JFST/article/download/3044/7591
Renaldi, Fransiskus Samuel; Universitas Indonesia
Sauriasari, Rani; Universitas Indonesia
Riyadina, Woro; Badan Penelitian dan Pengembangan Kesehatan
Maulida, Irianti Bahana; Institut Teknologi Bandung
2021-11-26 15:50:49
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/3044
Adherence; Type 2 Diabetes Mellitus; Medication Problems
Badan Pengembangan Sumber Daya Manusia Kesehatan, Kementrian Kesehatan Republik Indonesia
en
Diabetes melitus tipe 2 merupakan penyakit yang kompleks dan membutuhkan manajemen terapi yang serius. Kepatuhan menjadi masalah utama dalam pengobatan diabetes melitus tipe 2 tersebut dan dapat berdampak pada komplikasi yang akan sulit ditangani. Penelitian ini ditujukan untuk mengungkap berbagai permasalahan yang mendorong seorang pasien memilih untuk tidak patuh sehingga dapat membantu tenaga kesehatan dalam mencari akar masalah ketidakpatuhan pada penderita diabetes melitus tipe 2. Sebanyak 30 penderita diabetes melitus tipe 2 terbagi atas beberapa golongan kriteria, yaitu komplikasi, usia, dan tingkat kepatuhan. Pemilihan pasien dilakukan menggunakan metode sampling bola salju. Pengambilan data dilakukan dengan metode wawancara mendalam pada pasien yang dilakukan dengan teknik probing melalui telepon dan observasi langsung sebagai bentuk validasi. Data diolah dengan metode transkrip dan dianalisis secara tematik untuk kemudian diinterpretasikan dalam bentuk pernyataan hasil wawancara. Dari hasil penelitian didapatkan bahwa sebagian besar pasien menggunakan metformin. Hal ini dikarenakan banyak pasien merasa sesuai dengan metformin. Metformin dapat memberikan efek normalisasi gula darah yang diharapkan dengan efek samping ke sistem gastrointestinal yang masih dapat ditolerir. Di sisi lain, terdapat beberapa pasien yang sudah merasa jenuh dengan penggunaan obat secara terus-menerus, mereka ingin segera lepas dari obat. Perbandingan manfaat yang dirasakan ketika meminum obat dan tidak juga turut memotivasi pasien dalam menggunakan obat. Dari berbagai data yang telah dihimpun dalam penelitian ini, dapat disimpulkan bahwa kepatuhan berobat sangat dipengaruhi oleh efek yang diterima pasca penggunaan.
oai:ojs.jurnal.wima.ac.id:article/2054
2019-05-23T12:42:39Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/2054
2019-05-23T12:42:39Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 5, No 1 (2018); 38-44
Pola Penggunaan Omeprazole pada Pasien HIV & AIDS di UPIPI RSUD DR. Soetomo Surabaya
Ariana, Dona; Fakultas Farmasi, Universitas Katolik Widya Mandala Surabaya
Trijono, Erwin Astha; Unit Perawatan Intermediate Penyakit Infeksi, RSUD Dr. Soetomo Surabaya
Surdijati, Sri; Fakultas Farmasi, Universitas Katolik Widya Mandala Surabaya
Nathalia, Aditya; Unit Perawatan Intermediate Penyakit Infeksi, RSUD Dr. Soetomo Surabaya
2018-05-23 00:00:00
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/2054
id
Human Immunodeficiency Virus (HIV) is a virus that spreads through body fluids and attacks the immune system, especially CD4 + lymphocyte-T cells (CD4). AIDS is a retroviral disease characterized by severe immune suppression that causes opportunistic diseases, secondary neoplasms, and neurological disorders. Patients suffering from chronic diseases, such as HIV & AIDS patients may experience severe shocks or trauma. This condition can trigger the release of excessive stomach acid to experience erosion or acute gastric ulcers with bleeding. This injury is classified as a gastric ulcer. Treatment of ulcers is needed, because a continuous ulcer can cause bleeding. Gastrointestinal bleeding can manifest in the direction of melena and hematemesis. The therapy that can be used is omeprazole which is a class of proton pump inhibitors. Omeprazole can prevent mucosal damage from gastric acid and can inhibit excess acid production from gastric parietal cells. This study aims to present omeprazole therapy data which includes dosage, route of drug administration, duration of use and qualitative analysis of interactions related to medical record data at UPIPI Hospital Dr. Soetomo Surabaya. The research method used was observational retrospective on the medical record of patients with HIV & AIDS. Sampling was carried out from January 1 to December 31, 2015. The results showed that omeprazole was the most widely used gastric ulcer drug in HIV & AIDS patients, as many as 56 patients (91.80%). The most frequent doses, frequencies, and routes were omeprazole 40 mg 2x1 IV in 55 patients (90.16%). Omeprazole therapy was given to patients with HIV & AIDS at UPIPI Hospital Dr. Surabaya Soetomo, regarding the dosage, frequency, route, and duration of administration are in accordance with existing guidelines.
oai:ojs.jurnal.wima.ac.id:article/2139
2019-09-13T14:01:12Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/2139
2019-09-13T14:01:12Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 5, No 2 (2018); 74-78
Perbandingan Sintesis Antara Senyawa 2-Metoksikhalkon dan 2,4’-Dimetoksikhalkon dengan Bantuan Iradiasi Gelombang Mikro
Wibawa, Vincentius Tio Putra; Fakultas Farmasi, Universitas Katolik Widya Mandala, Surabaya
Soewandi, Ami; Fakultas Farmasi, Universitas Katolik Widya Mandala, Surabaya
Caroline, Catherine; Fakultas Farmasi, Universitas Katolik Widya Mandala, Surabaya
2019-09-13 16:01:02
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/2139
id
Chalcone (1,3-diphenylprop-2-en-1-one) is a precursor compound of flavonoids that have two aromatic rings connected by three α, β-unsaturated carbons. Chalcone can be synthesized by the base-catalysed crossed aldol condensation (Claisen-Schmidt) that reacts aromatic aldehyde with aryl ketone. In this research, synthesize of 2-methoxychalcone and 2,4'-dimethoxychalcone compounds with microwave irradiation assistance had been done. 2-methoxychalcone was synthesized from 2'-methoxyacetophenone and benzaldehyde, while 2,4'-dimethoxychalcone was synthesized from 2'-methoxyacetophenone and 4-methoxybenzaldehyde. The purity of the synthesis compounds were analyzed from melting point and thin layer chromatography data. Identification of structure was performed using infrared spectral data and proton nuclear magnetic resonance. From the obtained results, 2-methoxychalcone and 2,4'-dimethoxychalcone compounds can be synthesized by microwave irradiation assistance. The yield of 2,4'-dimethoxychalcone was 69,69%, while 2-methoxychalcone was 5,15%. The effect of the methoxy group (-OCH3) on benzaldehyde facilitates the reaction formation of khalkon compounds in terms of the yield of synthesis.
oai:ojs.jurnal.wima.ac.id:article/3392
2023-04-12T02:22:57Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/3392
2023-04-12T02:22:57Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 9, No 1 (2022): Februari; 12-16
Aktivitas Antihiperurisemia Ekstrak Etanol Biji Mahoni (Swietenia macrophylla) Terhadap Tikus Jantan
Situmorang, Novidawati Boru; Institut Kesehatan Medistra Lubuk Pakam
Dakhi, Juniaro Virgilius; Institut Kesehatan Medistra Lubuk Pakam
Marbun, Romauli Anna Teresia; Institut Kesehatan Medistra Lubuk Pakam
2022-03-30 00:00:00
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/3392
Hiperurisemia; Potassium Oxonate; Jus Hati Ayam; Biji Mahoni
en
Asam Urat merupakan penyakit yang paling banyak dialami oleh masyarakat Indonesia. Allopurinol sebagai inhibitor spesifik dari enzim canthin oksidasi (XO) terbukti efektif dalam menurunkan kadar asam urat, tetapi efek sampingnya dapat menyebabkan gagal hati, hepatitis, hiperbilirubinemi, diare serta mual muntah. Penelitian ini bertujuan untuk mengetahui potensi pemberian Ekstrak Etanol Biji Mahoni (EEBM) (Swientenia macrophylla) terhadap penururnan kadar asam urat pada tikus. Metode penelitian secara in vivo dengan penginduksi potassium oxonate dan jus hati ayam pada tikus. Sebanyak 5 kelompok tikus (Na-CMC 0,5%, tablet Allopurinol 3,6 mg/kgBB, EEBM (125, 250,375 mg/kgBB)) dilakukan selama 14 hari. Hasil uji ANOVA (p<0,05) menunjukkan adanya perbedaan rerata yang bermakna antara pretes 9,980 mg/dL dan postes 6,612 mg/dL sehingga EEBM berpotensi terhadapat penurunan kadar asam urat dalam darah tikus dengan jumlah rata-rata penurunan 3,392 mg/dL. Penurunan kadar asam urat tersebut diduga karena adanya kandungan senyawa flavonoid. Senyawa tersebut merupakan inhibitor xantin oksidase terkuat karena disebabkan oleh adanya gugus hidroksil C5 dan C7 selain itu, disebabkan juga oleh adanya C2 dan C3 sehingga lebih memudahkan interaksi dengan xantin oksidase. Mekanisme utama dari flavonoid berupa aktifitas inhibitor enzim dan antioksidan untuk radikal bebas.
oai:ojs.jurnal.wima.ac.id:article/2144
2019-09-13T14:01:12Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/2144
2019-09-13T14:01:12Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 5, No 2 (2018); 70-73
Isolasi dan Karakterisasi Fungi Endofit dari Daun Tanaman Bintaro (Cerbera odollam) yang Berpotensi sebagai Antibakteri
Wonowijaya, Suwandi; Fakultas Farmasi Universitas Katolik Widya Mandala Surabaya
Soegianto, Lisa; Fakultas Farmasi Universitas Katolik Widya Mandala Surabaya
2019-09-13 16:01:02
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/2144
id
The need of antibiotics is increasing, spurred to find compounds that have antimicrobial activity from natural ingredients. One way to obtain antimicrobial compounds is through endophytic fungi. This study aimed to isolate and characterize endophytic fungi obtained from the leaves of the plant Bintaro (Cerbera odollam) that potential as an antibacterial against Staphylococcus aureus and Escherichia coli. Leaf surface was sterilized by soaking in 70% alcohol for 2 minutes, 5.3% sodium hypochlorite for 5 minutes, 70% alcohol for 1 minute, rinsed with sterile distilled water and dried using sterile wipes. Bintaro leaf that have been sterilized was puton Potato Dextrose Agar (PDA) and then incubated at room temperature for 7-14 days. The growing fungi was inoculated in Potato Dextrose Yeast (PDY) for 7-14 days at room temperature based on the macroscopic difference. Endophytic fungi that have been purein macroscopic way was tested antibacterial activity on Staphylococcus aureus and Escherichia coli and continued to macroscopic and microscopic observation. Obtained three types of endophytic fungi were isolated from bintaro leaves (Cerbera odollam) with the code EB 1, EB 2 and EB 3 that suspected from genus Fusarium, Geotrichum and Aspergillus. The antibacterial activity test show that results of three endophytic fungi obtained has no antibacterial activity against Staphylococcus aureus and Escherichia coli.
oai:ojs.jurnal.wima.ac.id:article/3367
2023-04-12T02:22:58Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/3367
2023-04-12T02:22:58Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 9, No 1 (2022): Februari; 42-48
Studi Literatur : Aktivitas Antibakteri Daun Binahong (Anredera cordifolia) terhadap Staphylococcus aureus
Damayanti, Sevira Putri; Universitas Garut
Mariani, Ria; Universitas Garut
Nuari, Doni Anshar; Universitas Garut
2022-03-30 00:00:00
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/3367
Antibacterial, Binahong Leaf, Staphylococcus aureus.
en
Staphylococcus aureus merupakan bakteri yang dapat menyebabkan infeksi. Pengobatan infeksi biasanya menggunakan antibiotik, namun ditemukan masalah dalam penggunaan antibiotik salah satunya resistensi antibiotik. Binahong (Anredera cordifolia) dapat dijadikan sebagai alternative pengobatan antibakteri. Tujuan artikel review ini adalah untuk mereview ekstrak daun binahong yang dapat berpotensi menghambat pertumbuhan bakteri Staphylococcus aureus termasuk didalamnya menggali informasi mengenai konsentrasi yang memberikan zona hambat terhadap pertumbuhan Staphylococcus aureus dan golongan senyawa yang bertanggungjawab terhadap aktivitas antibakteri Staphylococcus aureus. Hasil uji antibakteri terhadap ekstrak daun binahong (Anredera cordifolia) dapat menghambat pertumbuhan bakteri Staphylococcus aureus dengan metode difusi pada konsentrasi 10%, 15%, 20% dengan diameter zona hambat 1,7 mm, 2,0 mm, 2,6 mm, sedangkan pada metode dilusi pada konsentrasi 25%. Pada fraksinasi daun binahong (Anredera cordifolia) dapat menghambat pertumbuhan Staphyloccus aureus (MIC 512 µg/ml). Hal ini dapat dikatakan bahwa ekstrak daun binahong (Anredera cordifolia) berpotensi dapat menghambat pertumbuhan bakteri Staphylococcus aureus. Golongan senyawa yang terkandung dalam ekstrak daun binahong (Anredera cordifolia) diduga adanya senyawa alkaloid, steroid, flavonoid dan fenol yang dapat menghambat pertumbuhan bakteri Staphylococcus aureus.
oai:ojs.jurnal.wima.ac.id:article/2175
2019-10-14T10:20:12Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/2175
2019-10-14T10:20:12Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 4, No 1 (2017); 25-29
Studi Penggunaan Antiemetik pada Pasien Demam Tifoid Rawat Inap di RSUD Kabupaten Sidoarjo
Wardhani, Hety Setya; Fakultas Farmasi, Universitas Katolik Widya Mandala, Surabaya
Surdijati, Siti; Fakultas Farmasi, Universitas Katolik Widya Mandala, Surabaya
Hasmono, Didik; Fakultas Farmasi, Universitas Airlangga, Surabaya
2019-10-14 12:20:06
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/2175
id
Typhoid fever is an infection of the small intestine caused by Salmonella thypi bacteria with symptoms of fever at night. This disease is a contagious disease that can affect many people and is still a health problem, especially in developing countries. This study aims to analyze patterns of antiemetic use in typhoid fever patients. This research was conducted at Sidoarjo District General Hospital using a retrospective method in the period of
January 1 to December 31, 2015. The sample was typhoid fever patients who were treated at the Sidoarjo District Hospital. The results obtained using the Health Medical Record (RMK) of patients who have been validated, 161 patients was detected and only 30 patients who is using antiemetic therapy. The antiemetic used is ondansetron. Ondansetron in single dose (3x4mg) iv used in 7 patients (23%) and (3x8mg) iv in 23 patients (77%). The duration of ondansetron use in typhoid fever patients in Sidoarjo District Hospital ≤ 2 days was 10 patients and ≥ 2 days was 20 patients. Antiemetics used were in accordance with the guidelines and no Drug Related Problems (DRPs) were obtained in typhoid fever patients as seen from their interactions with other drugs, the interval of administration, frequency of administration, duration of treatment, and dose of administration.
oai:ojs.jurnal.wima.ac.id:article/3421
2023-03-15T14:35:07Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/3421
2023-03-15T14:35:07Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 9, No 2 (2022): October; 67-72
Efektivitas Larvasida Ekstrak Etanol Bunga Kecombrang (Etlingera elaitor) dan Daun Jambu Biji (Psidium guajava) terhadap Mortalitas Larva Aedes aegypti
Bachtiar, Kamiel Roesman; Universitas Perjuangan Tasikmalaya
Rizkuloh, Lina Rahmawati; Universitas Perjuangan Tasikmalaya
Susanti, Susanti; Universitas Perjuangan Tasikmalaya
Nur Endah, Srie Rezeki; Universitas Perjuangan Tasikmalaya
2022-10-30 00:00:00
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/3421
bunga kecombrang, daun jambu biji, larvasida, Aedes aegypti
Universitas Perjuangan Tasikmalaya
ind
Berbagai jenis tanaman di Indonesia telah diketahui mengandung senyawa bioaktif yang dapat dimanfaatkan sebagai biopestisida. DIantaranya adalah bunga kecombrang dan daun jambu biji yang dapat berfungsi sebagai larvasida. Tujuan dari penelitian ini adalah mengetahui efektivitas campuran ekstrak etanol bunga kecombrang (Etlingera elaitor) dan daun jambu biji (Psidium guajava) terhadap mortalitas larva Aedes aegypti. Objek dalam penelitian ini adalah semua larva Aedes aegypti instar III yang berumur 3-4 hari Sampel total yang digunakan pada penelitian ini sebanyak 280 larva, yang di tentukan dengan teknik Purposive Sampling. Hasil penelitian menunjukkan ada pengaruh campuran ekstrak etanol bunga kecombrang (Etlingera elaitor) dan daun jambu biji (Psidium guajava) terhadap kematian larva nyamuk Aedes aegypti. Semakin tinggi konsentrasi ekstrak bunga kecombrang dan daun jambu biji yang diberikan, semakin banyak pula terjadinya kematian pada larva Aedes aegypti. Angka kematian tertinggi sebesar 90% dengan label konsentrasi uji 5 pada konsentrasi 5000 ppm (komposisi 1250 ppm ekstrak bunga kecombrang dan 3.750 ppm ekstrak daun jambu biji). Hasil analisis probit menunjukkan nilai LC50 pada larva Aedes aegypti untuk formula campuran ekstrak bunga kecombrang (Etlingera elaitor) dan daun jambu biji (Psidi guajava L.) adalah pada konsentrasi 2567,83 ppm
oai:ojs.jurnal.wima.ac.id:article/2180
2019-10-14T11:39:53Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/2180
2019-10-14T11:39:53Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 4, No 2 (2017); 57-63
Studi Penggunaan Obat Phenytoin Kurang dari Tiga Bulan terhadap Kadar Magnesium Serum dan Jumlah Kejang Pasien Epilepsi di RSUD DR. Soetomo Surabaya
Sanjiwani, Kadek Siska Febri; Fakultas Farmas,i Universitas Katolik Widya Mandala Surabaya
Sugianto, Paulus; Fakultas Kedokteran, Universitas Airlangga Surabaya dan Departemen Neurologi Rumah Sakit Umum Daerah Dr. Soetomo Surabaya
Kasih, Elisabeth; Fakultas Farmasi, Universitas Katolik Widya Mandala Surabaya
2019-10-14 12:31:26
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/2180
id
Epilepsy is a clinical phenomenon associated with an electrical explosion or excessive abnormal depolarization, which occurs in focus in the brain which causes a paroxysmal awakening. One of the anti-epilepsy drugs is phenytoin which belongs to the hydantoin class. This study aims to describe the serum Mg levels in epilepsy patients with phenytoin drug therapy in Dr. Soetomo General Hospital with a treatment period of less than three months and to identify DRP problems (Drug Related Problems). The method used in this study is prospectively presented by descriptive method (observational). The population in this study were epilepsy patients who were treated at the RSUD dr. Soetomo Surabaya with a sample of 28 epilepsy patients treated at the Outpatient and EEG Neurology Room at Dr. Soetomo General Hospital Surabaya. Results showed that Mg2+ levels in 28 patients with the highest magnesium levels were 2.46 mg / dL. While the lowest magnesium content is 1.78 mg / dL. Conclusions Patients' magnesium levels are still within the normal range but it has not been concluded that phenytoin can increase serum Mg2+ levels and there is no significant difference between phenytoin therapy in epilepsy patients
oai:ojs.jurnal.wima.ac.id:article/4361
2023-03-15T14:37:08Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/4361
2023-03-15T14:37:08Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 9, No 2 (2022): October; 99-104
Penghambatan Proliferasi Sel Kanker Payudara T47D oleh Ekstrak Air Daun Kelor (Moringa oleifera) dan Doxorubicin dengan Metode MTT Assay
Muna, Laili Nailul; Universitas Islam Negeri Sunan Kalijaga
Maulidina, Fradhika; Universitas Islam Negeri Sunan Kalijaga
2022-11-15 00:00:00
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/4361
Sitotoksik, Ekstrak Air Daun Kelor, T47D, Doxorubicin
en
Kanker merupakan jenis penyakit dengan prevalensi tertinggi yang dapat menyebabkan kematian, salah satunya kanker payudara. Pengobatan kemoterapi saat ini yang dilakukan banyak menimbulkan resiko terhadap penderitanya, misalnya menimbulkan resistensi, efek samping, daya efikasi yang semakin menurun. Model pengobatan yang efektif yakni mengkombinasikan agen kemoterapi dengan agen kemopreventif sebagai komplementer, sehingga dapat meminimalkan efek samping. Tujuan pada penelitian ini yakni mengetahui ativitas sitotoksik ekstrak air daun kelor dengan control positif doxorubicin terhadap sel kanker payudara T47D. Metode yang digunakan pada penelitian ini dengan MTT assay dengan hasil data berupa IC50. Hasil penelitian menunjukkan bahwa aktivitas sitotoksik terhadap sel kanker payudara T47D dengan IC50 lebih dari 1000 µg/ml, sedangkan doxorubicin memberikan nilai IC50 sebesar 8,17 µg/ml. Berdasarkan nilai IC50 tersebut ekstrak air daun kelor kurang poten dalam memberikan aktivitas sitotoksik terhadap sel kanker payudara T47D, namun memberikan perubahan morfologi sel.
oai:ojs.jurnal.wima.ac.id:article/4318
2023-08-06T16:20:07Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/4318
2023-08-06T16:20:07Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 10, No 1 (2023): February; 38-43
Review : Aktivitas Farmakologi Rumput Laut Genus Gracilaria (Rhodopyceae)
http://journal.wima.ac.id/index.php/JFST/article/download/4318/11499
http://journal.wima.ac.id/index.php/JFST/article/download/4318/12635
Nurazizah, Siska; STIKes Karsa Husada Garut
Rustamsyah, Ardi; STIKes Karsa Husada Garut
Perdana, Farid; STIKes Karsa Husada Garut
Sujana, Dani; STIKes Karsa Husada Garut
Kusmiyati, Mimin; STIKes Karsa Husada Garut
2023-04-27 00:00:00
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/4318
Rumput laut, Rhodophyceae, Gracilaria, Aktivitas Gracilaria.
dr. Siva Hamdani, MARS., M. Farm Dekan Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Garut
ind
Penyebaran rumput laut di Indonesia berada hampir diseluruh penjuru tanah air, namun produksi dan perdagangan rumput laut Indonesia sampai saat ini didominasi oleh genus Gracilaria dari kelas Rhodopyceae sebagai penghasil agar. Beberapa penelitian telah dilakukan dan menunjukan aktivitas dari Gracilaria. Tujuan review artikel ini adalah memberikan informasi tentang aktivitas farmakologi genus Gracilaria, dengan menggunakan metode studi literatur dari beberapa penelitian mengenai aktivitas dari Gracilaria. Beberapa spesies dari genus ini, berpotensi untuk aktivitas antioksidan, antibakteri, terapi adjuvans pada penyakit peridontal, antidiabetes, antiobesitas, antikolesterol, antiosteoklas, hepatoprotektor, antikanker, homeostatis, antikoagulan, antiulcer, dan imunostimulan.
oai:ojs.jurnal.wima.ac.id:article/2185
2019-10-14T11:39:53Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/2185
2019-10-14T11:39:53Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 4, No 2 (2017); 88-95
Studi Penggunaan Antihipertensi Golongan Angiotensin Receptor Blockers Terhadap Pasien Gagal Ginjal Kronik Stadium V di Rumah Sakit Bhayangkara Surabaya
Bura, Ursula Dua Klowe; Fakultas Farmasi, Universitas Katolik Widya Mandala Surabaya
Hasmono, Didik; Fakultas Farmasi, Universitas Airlangga Surabaya
Surdijati, Siti; Fakultas Farmasi, Universitas Katolik Widya Mandala Surabaya
Hartono, Ruddy; Rumah Sakit Bhayangkara Surabaya
2019-10-14 12:31:26
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/2185
id
Chronic renal failure is functional or structural kidney damage for more than 3 (three) months with or without a decrease in the Glomerular Filtration Rate (GFR), manifested as one of the pathological abnormalities or a sign of kidney damage, including blood or urine composition abnormalities or radiology abnormalities. In addition, chronic renal failure is also defined as a condition of GFR value of less than 60 ml / minute / 1.73 m2, for more than 3 (three) months with or without kidney damage. One of the risk factor for chronic renal failure is hypertension. The
purpose of antihypertensive administration is to prevent further damage to other organs, and also to reduce blood pressure in patients with chronic renal failure with a target of ≤ 140 mmHg. Angiotensin Receptor Blockers (ARB) is a first-line therapy used to reduce blood pressure so that it can delay kidney damage. The purpose of this study was to determine the pattern of antihypertensive drug use in the ARB class in patients with stage V chronic renal failure at Bhayangkara Hospital in Surabaya which was associated with clinical and laboratory data. The study was conducted observationally with a descriptive research design and retrospective data collection. The results showed that those who met the inclusion criteria were 30 patients using antihypertensive ARB therapy, where the highest number of sexes were 67% male and 33% female, the highest populations at the age of 31-70 years, the highest populations was 90% for ARB use and other antihypertensive drug and a single ARB use of 10 %, the most common combination ofantihypertensive group is ARB and Calsium Channel Blocker (CCB) 41%. The patient’s blood pressure mostly meets the target of ≤ 140 mmHg.
oai:ojs.jurnal.wima.ac.id:article/696
2015-06-19T09:14:35Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/696
2015-06-19T09:14:35Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 2, No 1 (2015)
Pembibitan Tanaman Purwoceng (Pimpinella pruatjan Molk) dengan Abu Vulkanik
Sudrajad, Heru; Balai Besar Penelitian dan Pengembangan Tanaman Obat dan Obat Tradisional
Suharto, .
Fauzi, .
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/696
en
Purwoceng (Pimpinella pruatjan Molk) represents one of the plantation medicines of Indonesia, which its
population was almost extinction (endangered). Purwoceng represent the original plant of Indonesia with the
swampy forest limited so that need special effort to preserve. Purwoceng represents the endemic species
which was growing in the mountain with the height of 1.800-3.500 m dpl in West Java (Pangrango
Mountain), Central Java (Dieng plateau) and East Java. Purwoceng seeds represent the highly cost commodity,
which is observed by a lot of jamu industry. Volcano dusty from Kelud mountain eruption on Thusday, 12
February 2014 diseminating widely and reach the region Yogyakarta, Central Java and West Java. The
volcano dusty could give the fertility of land and plant. It became the good materials for media planting. This
research was conducted in Medicinal Plant and Traditional Medicine Research and Development Centre with
Complete Random Device Methods, by using the volcano dusty media of Kelud mountain with the treatment
of giberelin 0 (control), 25, 50 and 75 ppm. The research showed that the purwoceng seed with the addition of
giberelin 25 ppm gave the best result of growth, the average of total leaf was 6,7 pieces, the length of handle
was 6,11 cm and the length of root was 11, 7 cm with the colour of leaf was yellow green at 3 month olds.
oai:ojs.jurnal.wima.ac.id:article/701
2020-02-05T14:37:28Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/701
2020-02-05T14:37:28Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 1, No 1 (2013); 36-39
Efek Pemberian Fraksi Ekstral Etanol Daun Sirih (Piper betle L) pada Penurunan Nafsu Makan dan Berat Badan Tikus Wistar Jantan
Mude, Serafin Anastasia
Tamayanti, Wahyu Dewi
Liben, Paulus
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/701
en
Telah dilakukan penelitian mengenai elek pemberian Iraksi air ekstrak etanol pada daun sirih (Piper betle L.)
pada penurunan nalsu makan dan berat badan pad a tikus Wistar. Pa~a penelitian ini tikus Wistar (Rattus
norvegicus) jantan sebanyak 25 ekor dibagi dalam 5 kelompok, kelompok kontrol negatil K(-); 3 kelompok uji
(Fl, F2, F3); dan kelompok kontrol positil (P). K(-) menerima perlakuan PGA 3% tanpa bahan aktil; Fl, F2, F3
masing-masing menerima Iraksi air ekstrak etanol daun sirih dengan dosis 300, 450, dan 600 mglkgBB;
dan P menerima orlistat dengan dosis 10,B mglkgBB. Setiap perlakuan diberikan seeara oral selama 7 hari
berturut-turut sekali sehari sebelum pengamatan. Jumlah sisa makanan dan berat badan (BB) ditimbang
dan dieatat setiap hari. Hasil penelitian menunjukkan bahwa Fl, F2, dan F3 mampu menurunkan nalsu
makan dan berat badan t ikus putih dibandingkan terhadap K(-). Selisih rerata penurunan jumlah makanan
adalah 3,4 g (Fl); 3,8 g (F2); dan 4,2 g (F3). Penurunan tersebut setara dengan penurunan jumlah makanan
kelompok P yaitu 4,2 g. Pada sisi BB, Fl; F2; dan F3 menunjukkan selisih rerata penurunan BB sebesar 14,6
g; 20,8 g dan 26,6 g. Selisih penurunan yang dihasilkan oleh F3 menunjukkan nilai mendekati penurunan
berat badan oleh kelompok P yaitu 28,6 g. Penelitian ini mengindikasikan bahwa pemberian Iraksi air
ekstrak etanol daun sirih (Piper betie L.) dalam dosis 300; 450; dan 600 mglkgBB seeara ora l mampu
menurunkan jumlah makanan dan berat badan pada tikus Wistar jantan . Perhitungan koelisien korelasi
menunjukkan tidak ada hubungan linear antara peningkatan dosis dengan peningkatan penurunan jumlah
makanan dan berat badan tikus.
oai:ojs.jurnal.wima.ac.id:article/4754
2024-01-29T05:16:56Z
JFST:ART
v2
http://journal.wima.ac.id/index.php/JFST/article/view/4754
2024-01-29T05:16:56Z
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Vol 10, No 2 (2023): October; 72-78
Review Artikel: Kandungan Senyawa Kimia dan Bioaktivitas dari Tanaman Faloak (Sterculia quadrifida)
Octaviany, Salma Tri; Fakultas Farmasi, Universitas Padjadjaran
Iskandar, Yoppi; Fakultas Farmasi, Universitas Padjadjaran
2023-11-16 02:39:11
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. All articles published Open Access will be immediately and permanently free for everyone to read and download. We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows: Creative Commons Attribution (BY NC SA)Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
url:http://journal.wima.ac.id/index.php/JFST/article/view/4754
tanaman faloak, obat tradisional, aktivitas farmakologi
Salma Tri Octaviany, Universitas Padjadjaran, Fakultas Farmasi
id
Indonesia memiliki sangat banyak aneka ragam flora dan fauna yang sangat bermanfaat, salah satunya tanaman faloak. Faloak (Sterculia quadrifida) merupakan salah satu tanaman herbal yang dapat dijadikan menjadi obat tradisional, sehingga masyarakat dapat disembuhkan dari berbagai penyakit, seperti hepatitis, diabetes, dan rheumatoid arthritis. Tanaman ini banyak dikembangkan pemanfaatannya untuk Kesehatan di Pulau Timur, Nusa Tenggara Timur (NTT). Review artikel ini dilakukan dengan melakukan kajian literatur ilmiah melalui penelusuran literatur dengan pencarian artikel dalam database jurnal penelitian melalui website internet. Penelitian ini dilakukan untuk mendapatkan informasi mengenai kandungan kimia yang terkandung dalam tanaman faloak, antara lain flavonoid, tanin, alkaloid, steroid, dan triterpenoid. Selain itu, penelitian ini dilakukan untuk mengetahui aktivitas farmakologi pada tanaman faloak, seperti antioksidan, antihiperglikemik, antiinflamasi, antipiretik, dan antibakteri. Masih belum banyak penelitian yang menjelaskan mengenai kandungan kimia dan aktivitas farmakologi yang ada pada tanaman faloak, sehingga diperlukan untuk penelusuran artikel untuk membahas kandungan kimia dan aktivitas farmakologi tanaman faloak secara ringkas dan sederhana.
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