ANTIDIABETIC EFFECT TEST OF CENTELLA ASIATICA EXTRACT IN HYPERCHOLESTEROLEMIA RAT MODELS

Nafiisah Nafiisah, Nur Signa Aini Gumilas, Ika Murti Harini

Abstract


Introduction: High blood sugar levels can lead to hypercholesterolemia, a condition where cholesterol levels in the blood exceed normal values. The active compounds in Centella asiatica (pegagan) have the potential to act as antidiabetic agents by stimulating insulin production by pancreatic beta cells.
Objective: This study aims to determine the effect of Centella asiatica extract on lowering fasting blood glucose (FBG) levels in hypercholesterolemia rat models.
Methods: Thirty-two test animals were divided into 4 groups: normal control, negative control, positive control (Simvastatin 1.8 mg/kgBW/day), and treatment (Centella asiatica extract 500 mg/kgBW/day). Hypercholesterolemia was induced using 2% cholesterol and 0.2% cholic acid. FBG measurement was performed after 5 weeks of administration of Centella asiatica extract and Simvastatin. Data analysis used one-way ANOVA and post hoc Bonferroni tests.
Results: The mean FBG (mg/dL) in P1=70.85±1.89; P2=151.82±2.91; P3=92.34±1.86; and P4=83.89±2.17. The one-way ANOVA test results showed statistically significant differences (p<0.01). The post hoc Bonferroni test results showed significant differences between all experimental groups.
Conclusion: Administration of Centella asiatica extract at a dose of 500 mg/kgBW can significantly lower FBG levels in hypercholesterolemia rat models compared to the administration of Simvastatin 1.8 mg/kgBW/day.

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Keywords


Centella asiatica; Simvastatin; Antidiabetic; Fasting blood glucose; Hypercholesterolemia

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DOI: https://doi.org/10.33508/jwm.v10i2.6031