Antibacterial Effect Of Curcuminoid Silica Nanoparticle To Escherichia Coli Bacteria

Bobby Hendrawan, Bernadette D Novita, Adi P Hendrata


Background: Escherichia coli is one of the main bacteria that cause urinary tract infection. In the past few years, Escherichia coli’s susceptibility to antibiotic has been decreased and causing antibiotic resistance. Furthermore, Curcuma longa plant has been used daily by the population as a cooking spice, and evidently has an antibacterial effect on some bacteria such as Staphylococcus aureus, Klebsiella pneumoniae, and Escherichia coli. Curcumin as the active ingredients of Curcuma longa has a low water solubility and poor absorption so that silica nanoparticle usage will help the solubility and absorption problem of Curcumin. Aim: This study aimed to know the antibacterial effect of Curcuminoid silica nanoparticles to
Escherichia coli. Methods: This research is an in vitro experimental study and checking by using a microdilution method and observed with a spectrophotometer. Results: There is 60,6% inhibition obtained at 1000 μg/mL. MIC and MBC were not obtained at 62,5 μg/mL to 32000 μg/mL.
Conclusion: Curcuminoid silica nanoparticles has no antibacterial effect against Escherichia coli.

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Flores-Mireles AL, Walker JN, Caparon M, Hultgren SJ. Urinary tract

infections: epidemiology, mechanisms of infection and treatment options. Nat Rev Microbiol [Internet]. 2015 Apr 8;13:269. Available from:

Carroll KC, Brooks GF, Butel JS, Morse SA, Mietzner TA. Jawetz, Melnick, & Adelberg Mikrobiologi Kedokteran. 25th ed. Adityaputri A, editor. Jakarta: EGC; 2010. 854 p.

Radji M. Buku Ajar Mikrobiologi Panduan Mahasiswa Farmasi dan Kedokteran. Jakarta: EGC; 2010. 320p.

Daoud Z. Escherichia coli isolated from urinary tract infections of

Lebanese patients between 2005 and 2012: epidemiology and profiles of.


Matuschek E. Antimicrobial Resistance of Escherichia coli Causing Uncomplicated Urinary Tract Infections: A European Update for 2014 and Comparison with 2000 and 2008. 2015;417–23

Vranic SM, Uzunovic A. Antimicrobial Resistance of Escherichia coli Strains Isolated From Urine at outpatient population: A Single Laboratory Experience. 2016;(February):121–4.

Davies J, Guy R, Johnson AP, Sheridan EA, Hope RJ. Descriptive epidemiology of Escherichia coli bacteremia in England, April 2012 to

March 2014. 2016;(March 2014):1–9.

Nasri H, Sahinfard N, Rafieian M, Rafieian S, Shirzad M. Turmeric: A spice with multifunctional medicinal properties. 2014;3(1):5–8.

Chattopadhyay I, Biswas K, Bandyopadhyay U, Banerjee RK. Turmeric and curcumin: Biological actions and medicinal applications. 2004;87(1).

Liu J, Chen S, Lv L, Song L, Guo S, Huang S. Recent progress in studying

curcumin and its nano-preparations for cancer therapy. Curr Pharm Des.


Moghadamtousi SZ, Kadir HA,Hassandarvish P, Tajik H, Abubakar S,

Zandi K. A Review on Antibacterial, Antiviral, and Antifungal Activity of

Curcumin. 2014;2014.

Basniwal RK, Buttar HS, Jain VK, Jain N. Curcumin Nanoparticles:

Preparation, Characterization, and Antimicrobial Study. 2011;2056–61.

Martien R, Adhyatmika, Irianto IDK, Farida V, Sari DP. Technology

Developments Nanoparticles as Drug. 2012;8(1):133–44

Carvalho DDM, Takeuchi KP, Geraldine RM, Moura CJ De, Célia M,

Torres L. Production, solubility and antioxidant activity of curcumin

nanosuspension. 2015;35(1):115–9.

Hartono SB, Hadisoewignyo L, Yang Y, Meka AK, Yu C. Amine functionalized cubic mesoporous silica nanoparticles as an oral delivery

system for curcumin bioavailability enhancement. Nanotechnology

[Internet]. 2016;27(50):1–7. Available from:


Silhavy TJ, Kahne D, Walker S. The bacterial cell envelope. Cold Spring

Harb Perspect Biol. 2010;2(5):1–16.

Koebnik R, Locher KP, Van Gelder P. Structure and function of bacterial

outer membrane proteins: Barrels in a nutshell. Mol Microbiol. 2000; 37(2):239–53.

Baron S. Medical Microbiology. 4th ed. Baron S, editor. Galveston:

University of Texas Medical Branch; 1996.

Niamsa N, Sittiwet C. Antimicrobial Activity of Curcuma Longa Aqueous

Extract. J Pharmacol Toxicol. 2009;

Lee W-H, Loo C-Y, Bebawy M, Luk F, Mason R, Rohanizadeh R. Curcumin and its Derivatives: Their Application in Neuropharmacology and Neuroscience in the 21st Century. Curr Neuropharmacol [Internet]. 2013;11(4):338–78. Available from:

Kharat M, Du Z, Zhang G, McClements DJ. Physical and Chemical Stability of Curcumin in Aqueous Solutions and Emulsions: Impact of pH, Temperature, and Molecular Environment. J Agric Food Chem. 2017;65(8):1525–32.

Hartono SB, Hadisoewignyo L, Yang Y, Meka AK, Antaresti, Yu C. Amine

functionalized cubic mesoporous silica nanoparticles as an oral delivery

system for curcumin bioavailability enhancement. Nanotechnology

[Internet]. 2016;27(50):1–7. Available from:




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