THE ROLE OF PROBIOTIC ON AFFECTING ELDERLY’S MOOD WITH PARKINSON’S DISEASE

Vanessa Susanto Tjokro, Susan Jocelyn Anggono, Anna Lewi Santoso

Abstract


Introduction: Parkinson’s Disease is a progressive disorder which affect the nervous system and cause movement problems in elderly. Parkinson’s disease has non-motor symptoms which include losing sense of smell, cognitive deficits, depression, constipation, and rapid eye movement sleep behaviour disorder. Constipation can also cause stress. Probiotics can help improve constipation in Parkinson’s disease patients. Fermented foods like pickles, yogurt, kimchi, and apple cider vinegar can be sources of probiotics. Moreover, probiotics can be consumed in the form of capsules, powder, and beverages as supplement.

Objective: To know the role of probiotic on  affecting elderly’s mood with Parkinson disease.

Materials and Method :  Journals and articles searching through PUBMED, google scholar, and other health information website between the years 2016-2024.

Result:  Gut brain axis mechanism can be activated by the accumulation of α-synuclein in the main pathway of the vagus nerve which lead to nerve degeneration. Dysfunction of the intestinal nervous system causes an imbalance of neurotransmitter regulation in the intestine, which then disturbs intestinal movement. In the other hand, neurotransmitter regulation imbalance can also cause stress or depression. Lactobacillus spp. and Bifidobacterium spp. can influenced normal gut flora which often used in depression therapy by reducing 5-HT metabolism that can improve cognitive function and other pathways.

Conclusion: Probiotic may help constipation and depression in Parkinson’s disease patient through gut brain axis mechanism. The form of probiotic given is fermented milk rich in probiotics (yogurt) with rich-fiber foods such as whole wheat products, lentils, nuts and apricots.

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Keywords


Parkinson’s disease; Constipation; Stress; Probiotic

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References


Belvisi, D., Pellicciari, R., Fabbrini, A., Costanzo, M., Pietracupa, S., Lucia, M. De, Modugno, N., Magrinelli, F., Dallocchio, C., Ercoli, T., Terravecchia, C., Nicoletti, A., Solla, P., Fabbrini, G., Tinazzi, M., Berardelli, A., & Defazio, G. (2020). Risk factors of Parkinson disease. https://doi.org/10.1212/WNL.0000000000010813

Bistas, K. G., & Tabet, J. P. (2023). The Benefits of Prebiotics and Probiotics on Mental Health. 15(8). https://doi.org/10.7759/cureus.43217

Chikatimalla, R., Dasaradhan, T., Koneti, J., Cherukuri, S. P., Kalluru, R., & Gadde, S. (2022). Depression in Parkinson ’ s Disease : A Narrative Review. 14(8). https://doi.org/10.7759/cureus.27750

Goya, M. E. (2020). Probiotic Bacillus subtilis Protects against α-Synuclein Aggregation in C. elegans. Elsevier.

He, Q., Si, C., Sun, Z., Chen, Y., & Zhang, X. (2022). The Intervention of Prebiotics on Depression via the Gut – Brain Axis. Multidisciplinary Digital Publishing Institute, 1–16.

Insanitaqwa, N. R. A. F. M. R. (2023). Open Access The Depiction Of General Physician ’ S Knowledge Level Of Parkinson ’ S Disease In. 9(2), 134–138. https://doi.org/10.21776/ub.mnj.2023.009.02.10

International Parkinson and Movement Disorder. (2020). Masalah diet dan kesehatan pencernaan pada penyakit pencernaan pada penyakit Parkinson: Fakta penting bagi pasien Parkinson: Fakta penting bagi pasien Dapatkah. pp. 1–2.

Johnson, D., Letchumanan, V., Thum, C. C., & Thurairajasingam, S. (2023). A Microbial-Based Approach to Mental Health : The Potential of Probiotics in the Treatment of Depression.

Khafifah, Z. (2024). Hubungan Tingkat Stres , Kecemasan , dan Depresi dengan Konstipasi Fungsional pada Mahasiswa Kedokteran. 11(1). https://doi.org/10.7454/jpdi.v11i1.1529

National Institute on Aging. (2022). Parkinson’s Disease: Causes, Symptoms, and Treatments. National Institute on Aging.

NINDS. (2020). Hope Through Research.

Xu, J., Wang, L., Chen, X., & Le, W. (2022). New Understanding on the Pathophysiology and Treatment of Constipation in Parkinson ’ s Disease. 14(June), 1–9. https://doi.org/10.3389/fnagi.2022.917499

Yang, Xiaoyun ; Zhou, Runjin ; Di, Wenhui ; He, Qian ; Huo, Q. (2021). Clinical Therapeutic Effects Of Probiotics In Patients With Constipation Associated With Parkinson Disease A Protocol For Systematic Review And Meta-Analysis. Lippincott Williams & Wilkins. https://doi.org/10.1097/MD.0000000000027705

Zein, I. S., Malikussaleh, U., Khairunnisa, K., & Neurologi, B. I. (2023). Parkinson Disease. 2(2).




DOI: https://doi.org/10.33508/jwmj.v6i4.6017

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