Difference Of Weight And Low-Density Lipoprotein (LDL) Level Of Rattus Norvegicus On Mediterranean Diet And Unsaturated Ketogenic Diet
Abstract
Introduction: Sedentary lifestyle continues to develop, which causes problems such as
obesity and coronary heart disease. This is caused by an increase in body weight and LDL
levels that can be overcame with a Mediterranean diet or an unsaturated ketogenic diet.
Purpose: To analyze the difference in weight and LDL of Rattus norvegicus on the
unsaturated ketogenic diet and the Mediterranean diet
Method: this study was an experimental study on 30 Rattus norvegicus divided into three
groups (control, unsaturated ketogenic, and Mediterranean), each group is divided into two,
according to the time of administration (two weeks and four weeks). After the intervention
was completed, bodyweight was calculated, and LDL levels were checked. Then, the data was
analyzed with one-way ANOVA test.
Results: The test results show p < 0.001 in the comparison between the three groups and p
<0.05 for comparison in the unsaturated ketogenic group. The Mediterranean diet shows p>
0.05, and the control diet leads p> 0.05. The data show that rapid weight loss (2 weeks) and
reduction in LDL (in 4 weeks) in the unsaturated ketogenic diet is better than the
Mediterranean diet or control. For medium-term weight loss (4 weeks), the Mediterranean
diet is better than the neither saturated ketogenic diet nor control.
Conclusion: There is a difference in weight and low-density lipoprotein (LDL) level of
Rattus norvegicus on the Mediterranean diet and unsaturated ketogenic diet. This favorable
condition might minimize the probability risk of obesity and coronary heart disease.
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Kossoff EH, Zupec-Kania BA, Rho JM. Ketogenic diets: an update for
child neurologists. Journal of child neurology. 2009.
Paoli A. Ketogenic diet for obesity: friend or foe? International Journal of Environmental Research and Public Health. 2014.
Bueno NB, de Melo ISV, de Oliveira SL, da Rocha Ataide T.
Very-low-carbohydrate ketogenic diet v. low-fat diet for long-term
weight loss: a meta-analysis of randomised controlled trials. Br J[dikutip 5 Maret 2019]; 110(07):1178–87. Tersedia pada: http://www.journals.cambridge.org/abstract_S0007114513000548
Dinas Kesehatan Propinsi JawaTimur. Profil kesehatan
propinsi jawa timur 2017. Nucleic Acids Res. 2006;34(11):e77–e77.
Riskesdas. Hasil utama riskesdas 2018. 2018;
Oemiati R, Rustika R. Penyakit jantung koroner [PJK] dengan
obesitas di kelurahan kebon kelapa, bogor. Bul Penelit Sist Kesehat.
;17(4):385–93
Kemenkes. Penyakit jantung penyebab kematian tertinggi. Kementrian Kesehat Republik Indones [Internet]. 2017;2015–6. Tersedia pada http://www.depkes.go.id/article/vie
w/17073100005/penyakit-jantungpenyebab-kematian-tertinggikemenkes-ingatkan-cerdik-.html
WHO. Fact sheet: cardiovascular diseases (CVDs). Who. 2017;
Schofield SE, Parkinson JRC, Henley AB, Sahuri-Arisoylu M,
Sanchez-Canon GJ, Bell JD. Metabolic dysfunction following
weight cycling in male mice. Int J Obes (Lond) [Internet]. 2017
[dikutip 20 Maret 2019];41(3):402–11. Tersedia pada http://www.ncbi.nlm.nih.gov/pubmed/27840414
Talib H, Mathew TC, Dashti HM Behbahani AI, Al-Zaid NS, AlMousawi M, et.al. Long term effects of ketogenic diet in obese subjects with high cholesterol level. Mol Cell Biochem. 2006;286(1–2):1–9.
Brehm BJ, Seeley RJ, Daniels SR, D’Alessio DA. A Randomized trial
comparing a very low carbohydrate diet and a calorie-restricted low fat diet on body weight and cardiovascular risk factors in healthy women. J Clin Endocrinol Metab [Internet]. 1 April 2003 [dikutip 5 Maret 2019];88(4):1617–23. Tersedia pada: https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.2002021480
Caraballo RH, Vining E. Ketogenic diet. In: Handbook of Clinical
Neurology. StatPearls Publishing;2012. hal. 783–93.
Holland AM, Kephart WC, Mumford PW, Mobley CB, Lowery
RP, Shake JJ, et al. Effects of a ketogenic diet on adipose tissue,
liver, and serum biomarkers in sedentary rats and rats that exercised
via resisted voluntary wheel running. Am J Physiol Integr Comp
Physiol [Internet]. Agustus 2016
DOI: https://doi.org/10.33508/jwmj.v3i1.3004
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