The Potential Diuretic Comparison Between Parts Of Cucumber (Cucumis Sativus L.) In Male Mus Musculus

Abstract

ntroduction : Cardiovascular diseases are one of the most common cause of death in
Indonesia. One kind of cardiovascular event is hypertension. Hypertension is a type of
Cardiovascular Disease which incidence rate is predicted to increase in the year of 2025.
Diuretic is one of the therapies that can be used for this disease. Diuretic works by decreasing
blood volume by managing water and sodium balance inside the body. This effect can be
obtained from Cucumber (Cucumis sativus L.).
Purpose : The aim of this study is to explain the differences in potential diuretic effect among
parts of Cucumber (Cucumis sativus L.).
Method : This study use post-test only control group design method in animal subject(in
vivo). Animal subjects in this study were 44 male Mus musculus. the animals were divided
into 9 treatment groups and 2 control groups. All Mus musculus get 1 mL methanol extract of
Cucumber (Cucumis sativus L.) according to their group. The animals were put in metabolic
cage to measure urine volume for 24 hours.
Results : Part of Cucumber (Cucumis sativus L.) that has the best potential diuretic were the
flesh and rind on 0,5 mg/mL. Part of Cucumber (Cucumis sativus L.) that has the highest
natriuresis and kaliuresis was whole fruit (flesh, rind, and seed).
Conclusion : Cucumber (Cucumis sativus L.) has a similar potential diuretic with Furosemid.
Low concentrations lead to better potential diuretic. Natriuresis and Kaliuresis can also be
found on Cucumber (Cucumis sativus L.).

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