COMPARISON OF THE EFFECTIVENESS OF GIVING BINAHONG LEAF (Anredera cordifolia (Ten) Steenis) AND PAPAYA LEAF (Carica papaya) ON SKIN WOUND HEALING IN WHITE RAT (Rattus novergicus)

Givenchy A Winarjo, Fransiscus Arifin, Dave G Oenarta

Abstract


Introduction: The incidence of acute and chronic injuries increases every year. Most injuries
in the world population, as many as 48%, are caused by trauma or surgery. the highest
incidence of wounds in the world based on the etiology was from surgery, which was 110.30
million cases. One of the handlings of wounds on the skin can be done by giving herbal
medicines, which can be easily accessed by the public, such as binahong leaves and papaya
leaves.
Purpose: To analyze the effectiveness of giving 40% binahong leaf extract cream and 40%
papaya leaf extract cream on the wound distance in the white rat wound healing process.
Method: this study is an experimental study with post-test only control group design
approach. The sampling technique used in this study was a random sampling method where
the number of samples was calculated using the Federer formula, with a total sample of 28
white rats. The distance of the wound was measured using a micrometer.
Results: Twenty-eight wound distance on rats were measured as subjects of the study and
then treated with binahong leaf extract cream and papaya leaf extract cream, then the wound
distance of each treatment was measured using a micrometer. According to the results, 40%
binahong leaf extract cream and 40% papaya leaf extract cream showed better effectiveness
in reducing the wound distance of white rat incision than the negative control group (cream
base) and positive control group (gentamicin ointment). According to the Mann Whitney test
comparing the P1 group (40% binahong leaf extract cream) and P2 (40% papaya leaf extract
cream), p-value >0.05, which is 0.543, which means that P1 has no significant mean
difference with P2.
Conclusion: There was no significant difference in effectiveness between the treatment of
40% binahong leaf extract cream and 40% papaya leaf extract cream.


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Keywords


Wounds incision; wound distance; cream; 40% binahong leaf extract; 40% papaya leaf extract cream.

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References


Hoediyanto H, Apuranto H, Kusuma SE, Solichin HS, Yudianto

A, Mutahal H, et al. Ilmu Kedokteran Forensik dan Medikolegal. 8th ed. Hoediyanto, Apuranto H, editors. Surabaya: Departeman Ilmu kedokteran

Forensik dan Medikolegal Fakultas Kedokteran Universitas Airlangga Surabaya; 2012.

Huda N, Ferbriyanti E, Laura D De. Edukasi Berbasis Nutrisi dan

Budaya

Rachmawati S. Study Makroskopi, Mikroskopi dan Skrining Fitokimia

Daun Aredera cordifolia (Ten.) Steenis. [Surabaya]: Airlangga; 2007.

Gauglitz GG, Korting HC, Pavicic T, Ruzicka T, Jeschke MG.

Hypertrophic Scarring and Keloids:Pathomechanisms and Current and

Emerging Treatment Strategies. Mol Med. 2011;17(1–2):113–25

Nasution AAM, Batubara DE. Perbandingan Efektifitas Ekstrak Daun Pepaya (Carica papaya) 100% dan Gentamisin Krim 0,1% Terhadap Ketebalan Epitel Pada Luka Sayat Tikus Wistar (Rattus Norvegicus). 2015;03(01):18–31

Kaur G, Utami NV, Usman HA. Effect of Topical Application of

Binahong [Anredera cordifolia (Ten .) Steenis] Leaf Paste in Wound

Healing Process in Mice. Althea Med J. 2014;1(1):6–11.

Astuti SM, Sakinah A.M M, Andayani B.M R, Risch A. Determination

of Saponin Compound from Anredera cordifolia (Ten) Steenis Plant

(Binahong) to Potential Treatment for Several Diseases. J Agric Sci.

;3(4):224–32

Novriansyah R. Perbedaan Kepadatan Kolagen Disekitar Luka

Insisi Tikus Wistar yang Dibalut Kasa Konvensional dan Penutup

Oklusif Hidrokoloid Selama 2 dan 14 Hari. [Semarang]: Diponegoro;

Yahya M. Khasiat Daun Pepaya Untuk Penderita Kanker. Novieta N,

editor. Jakarta: Dunia Sehat; 2012

Septiningsih E. Efek Penyembuhan Luka Bakar Ekstrak Etanol 70% Daun Pepaya ( Carica papaya L .) Dalam Sediaan Gel pada Kulit

Punggung Kelinci New Zealand. [Surakarta]: Muhammadiyah

Surakarta; 2008.

Paju N, Yamlean PVY, Kojong N. Uji Efektivitas Salep Ekstrak Daun

Binahong (Anredera cordifolia (Ten.) Steenis) pada Kelinci (Oryctolagus cuniculus) yang Terinfeksi Bakteri Staphylococcus aureus. Pharmacon J Ilm Farm - UNSRAT. 2013;2(01):2302-493

UNSRAT. 2013;2(01):2302-493

Federer WT. Experimental Design Theory and Application. New

Delhi: Calcutta Oxford & IBH; 1967.

Rupina W, Trianto HF, Fitrianingrum I. Efek Salep Ekstrak Etanol 70% daun Karamuting terhadap Re-epitelisasi Luka Insisi Kulit Tikus Wistar. 2016;4(1):2630.

Acar T, Tcylidiz R, Vahapogxlu H, Karakay AS, Aydin R. Efficansy of

Micronized Flavonoid Fraction on Healing in Thermally Injured Rat.

Amal Burn Fire Disasters [Internet]. 2002;15(1). Available from:

http://www.medbc.com/annals/review/vol_15/num_1/text/vol15n1p38.asp

PI GM, Nurdiana, Utami YW. The Effectiveness of Binahong Hydrogel ( Anredera cordifolia ( Ten ) Steenis ) to Reduce Macrophages Number in Proliferation Phase of Wound on Hyperglycemia Rats ( Rattus norvegicus ) Wistar Strain. Maj Kesehat FKUB. 2015;2(1):29–

16. Ansel Howard C. Pengantar Bentuk Sediaan Farmasi. Jakarta:

UI Press; 1989

Mucio M, Medeiros M De, Isaac C, Altran SC, Nicolosi JT, Jr CA, et al. Study of The Effectiveness of Papain in Wound Healing and

Specific Approach to Its Application in Patients With Venous Ulcers : A Systematic Review. Adv Plast Reconstr Surg. 2018;2(2):183–7.

Ramadhian MR, Widiastini AA. Kegunaan Ekstrak Daun Pepaya

(Carica papaya) Pada Luka. J Agromedicine. 2018;5(1):513–7.

Yanhendri, Yenny SY. Berbagai Bentuk Sediaan Topikal dalam

Dermatologi. Cermin Dunia Kedokt. 2012;39(6):423–30.

Ansel Howard C. Pengantar Bentuk Sediaan Farmasi. Jakarta: UI Press; 1989.




DOI: https://doi.org/10.33508/jwmj.v3i2.3181

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